Ether Lipid Metabolism

Phospholipids containing an aliphatic-ether bond or vinylether bond to the carbon-1 of L -glycerol yield 1-alkylglycerols or 1-alkenylglycerols when hydrolyzed. Platelet-activating factor (PAF; 1-alkyl-2-acetyl- sn -glycerophosphorylcholine) produces important biological effects such as the aggregation of platelets and induction of hypertensive response at very low concentrations. The metabolic pathway for alkylglycerolipids in the endoplasmatic reticulum of tumors and certain healthy cells consist of alkylation of dihydroxyacetone phosphate, ketone reduction, acylation, dephosphorylation, acylation, and/or transfer of phosphorylcholine or phosphorylethanolamine to alkyl glycerol. Pancreatic lipases, phospholipases, and phosphatases do not attack alkyl or 1-alkenyl chains of glycerolipids. Ether-linked phosphatidylcholines and phosphatidylethanolamines containing arachidonic and docosapentaenoic fatty acids are decreased in the blood plasma of hypertensive individuals.

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H3260 1-O-Palmityl-2,3-dipalmitoyl-rac-glycerol ~99%  
P6034 1-O-Palmityl-2-O-methyl-rac-glycero-3-phosphocholine  
P1402 1-O-Palmityl-2-acetyl-rac-glycero-3-phosphocholine ~99%  
H8771 1-O-Palmityl-2-acetyl-sn-glycero-3-phospho-(N,N,N-trimethyl)hexanolamine ~95%  
L7510 1-O-Palmityl-rac-glycero-3-phosphocholine ~99%  
H2510 1-O-Palmityl-rac-glycerol ~99%  
L5016 1-O-Palmityl-sn-glycero-3-phosphocholine ≥99%, synthetic Intermediate in the synthesis of platelet activating factor (PAF). Inactive form that can be used as a control in studies of PAF activity.
P7568 β-Acetyl-γ-O-alkyl-L-α-phosphatidylcholine from bovine heart lecithin ≥99%, lyophilized powder Phospholipid produced by lymphocytes, platelets and endothelial cells that induces platelet aggregation and is involved in inflammation, anaphylaxis and wound repair.
P4904 β-Acetyl-γ-O-hexadecyl-L-α-phosphatidylcholine hydrate ≥98% Extracellular signaling lipid; ligand for G protein-coupled platelet activating factor (PAF) receptors. Induces inflammation by increasing vascular permeability; activates MAP kinase (MAPK) and MAP kinase kinase (MAPKK) in CHO cells.