Attention:

Certain features of Sigma-Aldrich.com will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

Bile Acid Metabolism

Mammalian cells use multiple biochemical pathways to break down cholesterol into more polar, water-soluble bile acids that can function as emulsifying agents. A series of enzymatic reaction steps involving 7a-hydroxylations, epimerization of the 3ß-hydroxy group, saturation of the double bond, and side-chain cleavage or oxidation convert cholesterol into the bile acid chenodeoxycholic acid. 7-Deoxycholic acid is formed along a similar pathway, with an
additional 12a-hydroxylation and removal of the 7-hydroxy group. The hydrophobic/hydrophilic balance of the various bile acids facilitate the solubilization of monoacylglycerols, fat-soluble vitamins, and other lipids. This helps digestion and absorption but is also required for solubilization and excretion of lipophilic metabolites such as bilirubin.

Product #

Image

Description

Biochem/physiol Actions

Add to Cart

H1015 25-Hydroxycholesterol ≥98% 25-Hydroxycholesterol is a side-chain oxysterol that reportedly triggers activation of a number of cholesterol molecules. This triggers their movement from cell membrane to the endoplasmic reticulum (ER). 25-Hydroxycholesterol affects the immune system and has a key role in the pathogenesis of atherosclerosis.
G2878 Glycocholic acid hydrate synthetic, ≥97% (HPLC) Bile Acid
30968 Sodium deoxycholate monohydrate BioUltra, ≥99.0% (NT) Bile salt
G0759 Sodium glycochenodeoxycholate ≥97% (HPLC)  
T6260 Sodium taurochenodeoxycholate  
T9034 Taurocholic acid sodium salt hydrate BioXtra, ≥95% (TLC) Non-sulfated bile salt, physiological transport substrate for the bile salt export pump/sister of Pgp (BSEP/spgp), Na(+)/taurocholate cotransporter (NTCP) and MRP3 into the hepatic carnalicular.
U5127 Ursodeoxycholic acid ≥99%