Mevalonate Pathway

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79849   (±)-Mevalonic acid 5-phosphate lithium salt hydrate 95% (TLC) Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.
94259 (±)-Mevalonic acid 5-pyrophosphate tetralithium salt ≥80% (qNMR) Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase. Mevalonic acid 5-pyrophosphate was shown to elevate ubiquinone levels in rat liver tissues.
M4667 (±)-Mevalonolactone ~97% (titration)  
68519 (R)-(−)-Mevalonolactone ≥90.0% (GC) Classical enantiomerically pure metabolite in biosynthetic pathways leading to sterols, terpenes, carotenoids, and other natural products.
07841 (R)-Mevalonic acid 5-phosphate lithium salt 95% (TLC) Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.
77631 (R)-Mevalonic acid 5-pyrophosphate tetralithium salt ≥95% (TLC) Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.
50838 (R)-Mevalonic acid lithium salt ≥93.0% (qNMR) Mevalonic acid, is an intermediate in the mevalonate pathway, producing terpenes and steroids. This function provides treatment options metabolic disorders , R-mevalonate accumulates in patients with the autosomal recessively inherited mevalonic acidurias, an inborn error of cholesterol and nonsterol isoprene biosynthesis.
90469 (RS)-Mevalonic acid lithium salt ≥96.0% (GC) Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.
44714 (S)-Mevalonic acid lithium salt ≥96.0% (GC) Metabolite of the mevalonate pathway, which plays a key role in the biosynthesis of sterols, dolichol, heme and ubiquinone. Of interest for research in the disease areas oncology, autoimmune diseases, artherosclerosis and Alzheimer disease, as well as for inherited deficiencies of mevalonate kinase.
H6132 DL-3-Hydroxy-3-methylglutaryl coenzyme A sodium salt hydrate ≥90% (HPLC) DL-3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) is a substrate used to study the specificity and kinetics of the enzyme 3-hydroxyl-3-methyl-glutaryl coenzyme A (HMG-CoA) reductase. HMG-CoA is the key intermediate in the biosynthsis of terpenes, cholesterol, and ketone bodies. Its metabolism is the target of statin drugs used to control cholesterol levels.
A2181 Acetyl coenzyme A lithium salt ≥93% (HPLC) Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl-CoA is the starting compound for the citric acid cycle (Kreb′s cycle). It is also a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-CoA positively regulates the activity pyruvate carboxylase. It is a precursor of the neurotransmitter acetylcholine. Histone acetylases (HAT) use Acetyl-CoA as the donor for the acetyl group use in the post-translational acetylation reactions of histone and non-histone proteins.
Alterations in the gene encoding acetyl-CoA have been linked to Alzheimer′s disease and mild cognitive impairment. Defects in the gene cause myasthenic syndrome associated with episodic apnea.
A2056 Acetyl coenzyme A sodium salt ≥93% (HPLC), powder Acetyl-CoA is an essential cofactor and carrier of acyl groups in enzymatic acetyl transfer reactions. It is formed either by the oxidative decarboxylation of pyruvate in mitochondria, by the oxidation of long-chain fatty acids, or by the oxidative degradation of certain amino acids. Acetyl-CoA is the starting compound for the citric acid cycle (Kreb′s cycle). It is also a key precursor in lipid biosynthesis, and the source of all fatty acid carbons. Acetyl-CoA positively regulates the activity pyruvate carboxylase. It is a precursor of the neurotransmitter acetylcholine. Histone acetylases (HAT) use Acetyl-CoA as the donor for the acetyl group use in the post-translational acetylation reactions of histone and non-histone proteins.
658650 Acetyl-1,2-13C2 coenzyme A lithium salt 99 atom % 13C, 95% (CP)  
18629 Isopentenyl phosphate dilithium salt ≥95.0% (TLC) Isopentenyl monophosphate is phosphorylated into isopentenyl pyrophosphate at very low rates.
I0503 Isopentenyl pyrophosphate triammonium salt solution 1 mg/mL in methanol (:aqueous 10 mM NH4OH (7:3)), ≥95% (TLC)  
00297 Isopentenyl pyrophosphate trilithium salt ≥95.0% (TLC) Intermediate in terpene biosynthesis
591270 Mevalonolactone-(methyl-13C) 99 atom % 13C  
492469 Mevalonolactone-1-13C 99 atom % 13C, 98% (CP)  
486604 Mevalonolactone-2-13C 99 atom % 13C, 98% (CP)  
54747 γ,γ-Dimethylallyl phosphate ammonium salt ≥93.0% (TLC)  
69579 γ,γ-Dimethylallyl pyrophosphate ammonium salt ≥93.0% (TLC) Intermediate in terpene biosynthesis
D4287 γ,γ-Dimethylallyl pyrophosphate triammonium salt 1 mg/mL in methanol (:aqueous 10 mM NH4OH (7:3)), ≥90% (TLC) Intermediate in terpene biosynthesis