Membrane Preparations for Transporter Assays

Membrane Preparations and Kits for Transporter Assays

Membrane Preparations for Vesicular Transport Assays (VT) are suitable for general drug-efflux transporter interaction studies. Both substrate and inhibitor interactions can be assessed using vesicles. The success of substrate interaction studies strongly depends on the passive permeability of the compound. High permeability substrates might not be detected. Control Membranes with no-, or significantly lower transporter activity are also available.

HEK293-based Membrane Preparations for Transporter Assays

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SBVT14 SB-MRP2-HEK293
SBVT15 SB-MRP3-HEK293
SBVT16 SB-MDR1-HEK293 recombinant, expressed in HEK 293 cells
SBVT17 SB-BCRP-HEK293
SBVT18 SB-BSEP-HEK293
SBVT19 SB-mouseMdr1a-HEK293 recombinant, expressed in HEK 293 cells
SBVT20 SB-ratMdr1b-Sf9-HAM recombinant, expressed in baculovirus infected Sf9 cells
SBVT21 SB-ratBsep-HEK293 recombinant, expressed in HEK 293 cells

Membrane Preparations for Transporter Assays

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SBVT01 SB-MDR1-K recombinant, expressed in human cells (proprietary human “K” cells)
SBVT02 SB-BSEP-Sf9 membrane preparation for Vesicular Transport Assays, recombinant, expressed in baculovirus infected Sf9 cells
SBVT03 SB-BSEP-Hi5 Membrane preparation for Vesicular Transport Assays, recombinant, expressed in Baculovirus infected High-5 cells
SBVT04 SB-MRP1-Sf9 membrane preparation for Vesicular Transport Assays, recombinant, expressed in baculovirus infected Sf9 cells
SBVT05 SB-MRP2-Sf9 membrane preparation for Vesicular Transport Assays, recombinant, expressed in baculovirus infected Sf9 cells
SBVT06 SB-MRP3-Sf9 membrane preparation for Vesicular Transport Assays, recombinant, expressed in baculovirus infected Sf9 cells
SBVT07 SB-MRP4-HEK293 MRP4 human membrane vesicles
SBVT08 SB-MRP5-HEK293 MRP5 human membrane vesicles
SBVT09 SB-BCRP-M recombinant, expressed in human cells (expressed in proprietary human “M” cells)
SBVT10 BCRP human membrane preparation for Vesicular Transport Assays, recombinant, expressed in human amnion-derived mesenchymal (HAM) cells
SBVT12 SB-mouseBsep-Sf9 membrane preparation for Vesicular Transport Assays, recombinant, expressed in baculovirus infected Sf9 cells
SBVT13 SB-ratMrp2-HEK293 MRP2 rat vesicles

Negative Control Membrane

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SBCT01 SB-K-CTRL recombinant, expressed in human cells (proprietary human “K” cells)
SBCT02 SB M CTRL recombinant, expressed in human cells (expressed in proprietary human “M” cells)
SBCT03 SB beta gal Sf9 CTRL recombinant, expressed in baculovirus infected Sf9 cells
SBCT04 SB-beta-gal-Hi5-CTRL recombinant, expressed in Baculovirus infected High-5 cells
SBCT06 SB-HEK293-Mock-CTRL Negative control membrane for HEK293 transporter membranes
SBCT10 SB-beta-gal-Sf9-HAM-CTRL recombinant, expressed in baculovirus infected Sf9 cells

PREDIVEZ Reagent Kits

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SBPVR1 SB PREDIVEZ Reagent Kit for MDR1/P-gp
SBPVR2 SB PREDIVEZ Reagent Kit for MRP1
SBPVR3 SB PREDIVEZ Reagent Kit for MRP2, MRP3, and MRP5
SBPVR4 SB PREDIVEZ Reagent Kit for BCRP