Liver Drug Transporter/Toxicity Models

To aid in the investigation of specific drug transporters within the liver barrier, Sigma has generated transporter knockout (KO) cell lines using CompoZR Zinc Finger Nuclease (ZFN) technology in HepaRG cells. The HepaRG cells are ideal in that they express multiple transporters, are human derived and exhibit functionality of primary liver cells. The transporters targeted include: MDR1 (P-gp), BSEP, BCRP, MATE1, MRP2, MRP3, MRP4, MRP6, OATP1B1 and OATP1B3.