Liver Drug Transporter/Toxicity Models

To aid in the investigation of specific drug transporters within the liver barrier, Sigma has generated transporter knockout (KO) cell lines using CompoZR Zinc Finger Nuclease (ZFN) technology in HepaRG cells. The HepaRG cells are ideal in that they express multiple transporters, are human derived and exhibit functionality of primary liver cells. The transporters targeted include: MDR1 (P-gp), BSEP, BCRP, MATE1, MRP2, MRP3, MRP4, MRP6, OATP1B1 and OATP1B3.

Cell Line Models

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MTOX1010 HepaRG 5F Control Cells 1 vial
MTOX1010P24 HepaRG 5F Control Cells one assay ready, 24 well plate
MTOX1010P48 HepaRG 5F Control Cells one assay ready, 48 well plate
MTOX1010P96 HepaRG 5F Control Cells one assay ready, 96 well plate
MTOX1016 OATP1B3 Knockout HepaRG Cells 1 vial
MTOX1016P24 OATP1B3 Knockout HepaRG Cells one assay ready, 24 well plate
MTOX1016P48 OATP1B3 Knockout HepaRG Cells one assay ready, 48 well plate
MTOX1016P96 OATP1B3 Knockout HepaRG Cells one assay ready, 96 well plate
MTOX1018 BSEP Knockout HepaRG Cells 1 vial
MTOX1018P24 BSEP Knockout HepaRG Cells one assay ready, 24 well plate
MTOX1018P48 BSEP Knockout HepaRG Cells one assay ready, 48 well plate
MTOX1018P96 BSEP Knockout HepaRG Cells one assay ready, 96 well plate
MTOX1019 MDR1 Knockout HepaRG Cells 1 vial
MTOX1019P24 MDR1 Knockout HepaRG Cells one assay ready, 24 well plate
MTOX1019P48 MDR1 Knockout HepaRG Cells one assay ready, 48 well plate
MTOX1019P96 MDR1 Knockout HepaRG Cells one assay ready, 96 well plate
MTOX1021 HepaRG Cells BCRP (-/-) one vial
MTOX1021P24 HepaRG Cells BCRP (-/-) one assay ready, 24 well plate
MTOX1021P48 HepaRG Cells BCRP (-/-) one assay ready, 48 well plate
MTOX1021P96 HepaRG Cells BCRP (-/-) one assay ready, 96 well plate
MTOX1105 MRP3 Knockout HepaRG Cells 1 vial
MTOX1105P24 MRP3 Knockout HepaRG Cells one assay ready, 24 well plate, MRP3 Knockout HepaRG Cells
MTOX1105P48 MRP3 Knockout HepaRG Cells one assay ready, 48 well plate, MRP3 Knockout HepaRG Cells
MTOX1105P96 MRP3 Knockout HepaRG Cells one assay ready, 96 well plate, MRP3 Knockout HepaRG Cells

HepaRG Cell Culture Medium Supplements

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MTOXHMSUP HepaRG Maintenance Medium Supplement sterile-filtered
MTOXHPSUP HepaRG Pre-Induction Medium Supplement sterile-filtered
MTOXHRSUP HepaRG Recovery Medium Supplement sterile-filtered
MTOXHSFISUP HepaRG Serum-free Induction Medium Supplement