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Liver Drug Metabolism Knockout Models

To aid in the investigation of specific drug metabolizing pathways and possible drug-drug interactions within the liver, Sigma has generated nuclear receptor knockout (KO) cell lines using CompoZr Zinc Finger Nuclease (ZFN) technology in HepaRG cells. The HepaRG cells are ideal in that they express multiple transporters, are human derived and exhibit functionality of primary liver calls. This includes the activation of the nuclear receptor, AhR, CAR, and PXR and the corresponding induction of CYP1A2, CYP2B6, and CYP3A4. The nuclear receptor targets include: AhR, CAR, and PXR.