Induced Pluripotent Stem Cells and Reagents

Somatic cell reprogramming technology enables researches to build disease models by generating iPSC lines from patient samples, differentiate them into targeted primary cells, and manifest the disease symptoms in vitro. To date, many disease models for CNS disorders, such as Alzheimer′s disease (AD), Parkinson′s disease (PD), autism, schizophrenia, and amyotrophic lateral sclerosis (ALS), have been generated using this strategy. However, this strategy has its limitations as it is often complicated by the diverse genetic backgrounds of individual patients.

To address researchers′ critical needs for disease-specific isogenic controls, Sigma-Aldrich, in collaboration with XCell Sciences, now offers a full portfolio of knockout iPSC lines that mimic loss of function of genes associated with various CNS disorders. These isogenic knockout iPSC lines and their derivatives offer novel tools for controlled experiments to decipher functionality of each disease-associated gene, and thus the mechanism underlying the disease. Combined with our already extensive portfolio of iPS cell lines and reagents, Sigma-Aldrich provides a full tool-box to further the development of drug discoveries in the realm of stem cell research.