Natriuretic Peptides

Circulating natriuretic peptide hormones act to maintain homeostasis with regard to blood volume, blood pressure, and salt balance. When the myo-endocardial cells of the atrium sense an increase in blood volume or pressure, they release A- or B-type atrial natriuretic peptides (ANPs). These peptides, acting through guanylate cyclase receptors, dilate blood vessels and stimulate salt excretion by inhibiting sodium chloride reabsorption in the collecting ducts of the kidney. As the salt concentration within the ducts increases osmotic pressure, diuresis occurs. C-type natriuretic peptide, produced in the hypothalamus and pituitary, causes dilation in the circulatory system, including the heart, but has little effect on the kidney. Urodilatin is a paracrine natriuretic peptide, produced in the proximal tubules of the kidney, and acting in the collecting ducts. We offer all of these peptides, from several vertebrate sources, as well as some active peptide fragments. Atriopeptin II, for example, relaxes smooth muscle both in veins and in the gut. Dendroaspis natriuretic peptide, originally isolated from green mamba snake venom, is structurally similar to the A-,B-, and C-ANP′s, and exerts the same physiological functions.

Researchers will also find here several peptide hormones with effects on appetite and energy metabolism. Pancreatic polypeptide and derivatives work through neuropeptide Y receptors. Pancreastatin, which is elevated in diabetes, and the catecholamine release inhibitor catestatin are peptide hormones resulting from the enzymatic cleavage of chromagranin.

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A1663 Atrial Natriuretic Peptide human ≥97% (HPLC) Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.
A8208 Atrial Natriuretic Peptide rat ≥97% (HPLC) Atrial natriuretic peptide (ANP) is synthesized in myoendocrine cells of the heart from which it is released into the circulation. It exerts natriuretic, diuretic, and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure homeostasis.
A9035 Atriopeptin II rat Activates particulate guanylyl cyclase; cardiac atrial peptide which relaxes both intestinal and vascular smooth muscle.
B0777 Brain natriuretic peptide fragment 7-32 ≥97% (HPLC)  
B5900 Brain Natriuretic Peptide-32 human ≥97% (HPLC), powder Brain natriuretic peptide (type B natriuretic peptide) was originally isolated from brain, but is mainly produced in myoendocrine cells of the heart ventricles from which it is released into the circulation. It is involved in blood pressure control and cardiovascular homeostasis.
B9901 Brain Natriuretic Peptide-32 rat ≥97% (HPLC), powder Brain natriuretic peptide (type B natriuretic peptide) was originally isolated from brain, but is mainly produced in myoendocrine cells of the heart ventricles from which it is released into the circulation. It is involved in blood pressure control and cardiovascular homeostasis.
C6249 Catestatin The catestatin peptide is produced from its precursor chromogranin A protein. Catestatin is a cationic and hydrophobic peptide that can stimulate histamine release from mast cells and exhibits potent catecholamine relase-inhibitory activity.
D6189 Dendroaspis Natriuretic Peptide trifluoroacetate salt ≥90% (HPLC) Structural homolog of natiuretic peptides containing a 17 amino acid disulfide ring similar to ANP, BNP, and CNP that mediate their physiological effects through particulate guanylyl cyclase receptors generating cGMP.
N8279 des(Arg30, Pro31)-Dendroaspis Natriuretic Peptide >95% (HPLC), solid  
N8768 Natriuretic Peptide, C-Type ≥95% (HPLC) C-type natriuretic peptide is produced in the hypothalamus, anterior pituitary, and most major endocrine glands. It has potent venodilatory and coronary vasodilatory effects, but minimal effects on renal function.
Natriuretic Peptide, C-Type (NPC) plays a vital role in regulation of blood pressure and body fluid homeostasis. NPC-mediated signaling is essential for endochondral ossification. NPC acts as a ligand for natriuretic peptide receptor B (NPR-B). NPC interacts with receptors on vascular smooth muscle cells (VSMCs) and functions as an autocrine/paracrine endothelium-derived hormone. It is also implicated in the endothelial dysfunction and regulation of adipogenesis, which has a crucial role in the development of obesity in childhood. NPC has potential as a marker for obesity and bone injury induced by steroid hormones. In vitro studies show that NPC is involved in the inhibition of smooth muscle cell proliferation, natriuresis, diuresis, vasodilation and inhibition of the renin- angiotensin system. NPC is associated with the development of myocardial infarction and heart failure. Plasma NPC levels can be used as a biomarker for the therapeutic efficacy of metoprolol on postural tachycardia syndrome (POTS) in children.
P4488 Pancreatic Polypeptide Fragment 1-17–[Ala31, α-Aminoisobutyryl32]-Neuropeptide Y Fragment 18-36 ≥95% (HPLC), solid Selective agonist of the neuropeptide Y receptor.
P9809 Pancreastatin Fragment 37-52 human ≥97% (HPLC)  
U5754 Urodilatin human ≥97% (HPLC) Urodilatin is a natriuretic factor belongs to atrial natriuretic peptide family which along with four cardiac hormones decreases human renal carcinoma cell numbers. Urodilatin induces cGMP synthesis as well as stimulates cGMP accumulation by threefold in inner medullary collecting ducts (IMCD).
Urodilatin is a natriuretic factor that is produced in the kidney and secreted into the urine. It regulates water and sodium reabsorption in the collecting duct.