Leptin and Leptin Receptors

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L3772 Leptin from mouse >98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder Absence of leptin in mice causes severe obesity and hypothermia at temperature below thermoneutrality. It also controls feeding behavior. Leptin signaling is crucial for the bone formation.
Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo.
Human and mouse leptin share ~84% sequence identity.
L5037 Leptin from rat ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder In rodents with uncontrolled diabetes mellitus, leptin is crucial for normalizing hyperglycemia. In the digestive tract, it also participates in the absorption of dietary molecules via controlling transporters activity.
Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo.
Human and mouse leptin share ~84% sequence identity.
L4146 Leptin human >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo.
Human and mouse leptin share ~84% sequence identity.
Mutations in LEP (leptin) are linked with type-2 diabetes. Presence of high levels of leptin in plasma is related to adiposity.
L6788 Leptin Fragment 116-130 Amide mouse >95% (HPLC), white powder Mimics the effects of recombinant leptin on body weight and food intake.
L4912 Leptin Receptor/Fc Chimera from mouse ≥97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested Leptin receptor (OB-R) is a single membrane-spanning receptor most related to the gp-130 signal-transducing component of the IL-6 receptor, the G-CSF receptor and the LIF receptor. OB-R, also known as B219, is expressed in the yolk sac, early fetal liver, enriched hematopoitic stem cells and in a variety of lymphohematopoietic cell lines. OB-R is also expressed at high levels in adult reproductive organs. OB-RL action in hepatic cells may be equivalent to that of IL-6 receptor. Leptin does not play a specific role in muting insulin action on hepatoma cells and may not contribute to the diabetic symptoms associated with obesity.
Leptin receptor is important for regulating appetite and energy expenditure. The neuroendocrine hormone, leptin, works through leptin receptor. In humans and mice, problems in expression of leptin or leptin receptor are associated with obesity.
L4787 Leptin Receptor/Fc Chimera human ≥97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested Leptin receptor (LEPR) is linked with risk of coronary artery disease. Mutation in LEPR is associated with low BMI (body mass index), increased leptin levels and some cancers. In humans and mice, problems in expression of leptin or leptin receptor are associated with obesity.
Leptin receptor (OB-R) is a single membrane-spanning receptor most related to the gp-130 signal-transducing component of the IL-6 receptor, the G-CSF receptor and the LIF receptor. OB-R, also known as B219, is expressed in the yolk sac, early fetal liver, enriched hematopoitic stem cells and in a variety of lymphohematopoietic cell lines. OB-R is also expressed at high levels in adult reproductive organs. OB-RL action in hepatic cells may be equivalent to that of IL-6 receptor. Leptin does not play a specific role in muting insulin action on hepatoma cells and may not contribute to the diabetic symptoms associated with obesity.