Biogenic Amine Transport Inhibitors

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T7947 (R)-Tomoxetine hydrochloride solid Norepinephrine uptake blocker.
 
Q109 6-Nitroquipazine maleate salt solid Potent and selective serotonin transport blocker.
0.1 M HCl: 16 mg/mL
0.1 M NaOH: insoluble
H2O: 5 mg/mL
methanol: 6 mg/mL
A8404 Amitriptyline hydrochloride ≥98% (TLC), powder Tricyclic antidepressant; inhibits the norepinephrine and serotonin transporters with Kis of 100 nM and 14.7 nM, respectively; high in vitro affinity for α1-adrenoceptors, serotonin and muscarinic acetylcholine receptors.
H2O: soluble
ethanol: soluble
A129 Amoxapine Tricyclic antidepressant; inhibits uptake of norepinephrine; inhibits 5-HT2 serotonergic receptors.
methanol: soluble
B102 Bupropion hydrochloride ≥98% (HPLC), solid Inhibits the dopamine and norepinephrine transporters with Kis of 2.8 μM and 1.4 μM, respectively. Does not inhibit the serotonin transporter (Ki = 45 μM). Antidepressant.
H2O: 15 mg/mL clear
C7861 Citalopram hydrobromide ≥98% (HPLC) Potent and selective serotonin uptake inhibitor (Ki = 5.4 nM); antidepressant
chloroform: soluble
methanol: soluble
C7291 Clomipramine hydrochloride ≥98% (HPLC), powder Tricyclic antidepressant; inhibits serotonin and norepinephrine transporters.
0.1 M HCl: soluble
H2O: 25 mg/mL
D3900 Desipramine hydrochloride ≥98% (TLC), powder Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 4 nM) than the serotonin transporter (Ki = 61 nM).
H2O: 50 mg/mL
D4526 Doxepin hydrochloride ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder Tricyclic antidepressant that is a more potent inhibitor of norepinephrine uptake than of serotonin uptake; antagonist at H1 histamine, muscarinic cholinergic, and α-adrenoreceptors.
1 M HCl: 50 mg/mL
H2O: soluble
F132 Fluoxetine hydrochloride solid Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor and functions as an antidepressant. This drug works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses.
Selective serotonin reuptake inhibitor; antidepressant.
DMSO: >5 mg/mL
H2O: 4 mg/mL
F2802 Fluvoxamine maleate solid Selective serotonin reuptake inhibitor; antidepressant.
H2O: soluble
G9659 GBR 12935 dihydrochloride ≥98% (TLC), powder Inhibits the dopamine and norepinephrine transporters with Kis of 21.5 nM and 225 nM, respectively. Does not inhibit the serotonin transporter (Ki = 6.5 μM). Binds to a nondopaminergic piperazine site in blood platelets and brain that has been identified as cytochrome P450.
H2O: 20 mg/mL (with warming)
I7379 Imipramine hydrochloride ≥99% (TLC) Tricyclic antidepressant; inhibits the serotonin and norepinephrine transporters with Kis of 7.7 nM and 67 nM, respectively. Has little effect on the dopamine transporter (Ki = 25 μM).
H2O: 50 mg/mL
I119 Indatraline hydrochloride solid Potent inhibitor of dopamine, norepinephrine and serotonin uptake.
H2O: 2 mg/mL
M9651 Maprotiline hydrochloride >99% (HPLC), powder Selective norepinephrine uptake inhibitor.
H2O: 50 mg/mL
M2017 Mazindol ≥98% (TLC), powder Anorectic agent; inhibits the dopamine, norepinephrine and serotonin transporters with Kis of 27.6 nM, 3.2 nM, and 153 nM, respectively.
DMSO: 10 mg/mL
M0443 Mirtazapine ≥98% (HPLC) Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA). Mirtazapine agonizes selective adrenergic and serotonergic receptors so that both NE release and 5-HT1A mediated serotonergic signaling are increased.
DMSO: 8 mg/mL clear
N5536 Nefazodone hydrochloride ≥98% (HPLC), solid Novel antidepressant; mixed 5-HT2A serotonin receptor antagonist/serotonin uptake inhibitor.
DMSO: ≥10 mg/mL
H2O: insoluble
N151 Nisoxetine hydrochloride solid, ≥98% (HPLC) Potent and selective inhibitor of the norepinephrine transporter (Ki = 5.1 nM).
H2O: 20 mg/mL
ethanol: 50 mg/mL
F133 Norfluoxetine hydrochloride ≥97%, solid Fluoxetine metabolite; more potent inhibitor of serotonin uptake than fluoxetine with a half-life in vivo of 5-7 days.
DMSO: >5 mg/mL
H2O: >4 mg/mL
N7261 Nortriptyline hydrochloride ≥98% (TLC), powder Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 3.4 nM) than the serotonin transporter (Ki = 161 nM). 5-HT2 serotonin receptor antagonist.
H2O: soluble
ethanol: 100 mg/mL
P8813 Protriptyline hydrochloride ≥99% (TLC), powder Norepinephrine uptake blocker.
H2O: 50 mg/mL
F1678 R-(−)-Fluoxetine hydrochloride >98% (HPLC), solid Selective serotonin reuptake inhibitor.
H2O: soluble >10 mg/mL
R6527 Reboxetine mesylate hydrate >96% (HPLC), solid Reboxetine mesylate hydrate is a selective noradrenaline uptake inhibitor.
H2O: >5 mg/mL at ≤60 °C
F1553 S-(+)-Fluoxetine hydrochloride ≥98% (HPLC), solid Fluoxetine hcl (hydrochloride) is a selective serotonin reuptake inhibitor and functions as an antidepressant. This drug works at presynaptic terminals where it prevents the reuptake of serotonin, resulting in the accumulation of serotonin in extracellular fluid at synapses.
Selective serotonin reuptake inhibitor.
H2O: soluble ≥20 mg/mL
T1692 Tianeptine sodium salt hydrate ≥98% (HPLC), powder   DMSO: ≥20 mg/mL
T6154 Trazodone hydrochloride ≥99% (HPLC), powder Antidepressant that potentiates the activity of serotonin uptake blockers and has full 5-HT2C serotonin receptor agonist activity. It is metabolized to the 5-HT1 serotonin receptor agonist 1-(3-Chlorophenyl)piperazine.
0.1 M HCl: soluble 7.4  mg/mL
45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: soluble 23.3  mg/mL
DMSO: soluble
H2O: soluble hazy, colorless
methanol: soluble 25  mg/mL clear, colorless
T3146 Trimipramine maleate salt ≥98% (TLC), powder Antidepressant; serotonin transport blocker that also blocks norepinephrine uptake.
chloroform: soluble 50 mg/ml clear, colorless to faintly yellow
Z101 Zimelidine dihydrochloride solid Serotonin transport blocker; antidepressant.
0.1 M HCl: 45 mg/mL
H2O: 66 mg/mL