CD45-Associated Protein Tyrosine Phosphatase (CD45)

Product #

Description

Biochem/physiol Actions

CAS Number

Add to Cart

SML1337 NQ301 ≥98% (HPLC) NQ301 is an antithrombotic agent. Recent study shows that NQ301 (Compound 211) is a highly potent, selective, non-competitive allosteric inhibitor of CD45 that selectively inhibits dephosphorylation of substrate Lck pY-505 versus Lck pY-393. NQ301 prevents T cell receptor-mediated activation of Lck, Zap-70 and MAPK, and IL-2 production in primary T-cells. NQ301 exhibits immunosuppressive activity in mice.
130089-98-4