Angiotensins

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SML1370 A-779 trifluoroacetate salt ≥98% (HPLC) A-779 (D-Ala7-Ang-(1-7)) is a potent and selective antagonist of angiotensin (1-7), an endogenous peptide that acts through activation of a non-AT1, non-AT2 receptor, Mas, and opposes the activity of angiotensin. A-779 has an IC50 of 0.3 nM for Mas with negligible affinity for either AT1R or AT2R.
SML1374 Alamandine trifluoroacetate salt ≥98% (HPLC) Alamandine is an endogenous heptapeptide that can be formed from angiotensin A by angiotensin converting enzyme-2 or directly from angiotensin-(1–7) by decarboxylation of its aspartate residue. Alamandine′s activity is similar to Ang-(1–7) rather than that of angiotensin II or angiotensin A. However, Alamandine acts at a different receptor, the Mas-related receptor, MrgD. Alamandine causes vasodilation, and has antifibrosis and antihypertensive activity.
A9402 [Val5]-Angiotensin I bovine ≥97% (HPLC) Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.
A9202 Angiotensin Fragment 1-7 acetate salt hydrate ≥90% (HPLC), powder Angiotensin I metabolite that is an AT2 receptor agonist.
A9650 Angiotensin I human acetate salt hydrate ≥90% (HPLC) Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.
A6402 [Asn1, Val5]-Angiotensin II ≥97% (HPLC) Synthetic angiotensin agonist that is involved in the regulation of blood pressure, water consumption, and hydromineral balance in fish.
A9900 [Sar1, Thr8]-Angiotensin II acetate salt hydrate ≥97% (HPLC) Potent, long-acting antagonist of angiotensin II.
A2275 [Sar1, Val5, Ala8]-Angiotensin II acetate salt hydrate ≥97% (HPLC), powder Competitive angiotensin II antagonist; inhibits pressor effects of angiotensin II in rats and lowers blood pressure in humans.
A2900 [Val5]-Angiotensin II acetate salt hydrate ≥95% (HPLC), powder Angiotensin II analog that is an agonist AT1 angiotensin receptors.
A9525 Angiotensin II human ≥93% (HPLC), powder Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. AngII in blood is produced from angiotensinogen via renin and angiotensin converting enzyme (ACE). It works via binding to specific receptors present on cell membranes. AngII is a component of the renin-angiotensin system. It is associated with vasoconstriction, induction of vascular smooth muscle cell growth, stimulation of protooncogene expression, modulation of myocardial hypertrophy, renal failure and fibrosis.
A0911 [Ile7]-Angiotensin III acetate salt hydrate ≥95% (HPLC) In [Ile7]-Angiotensin III (Ile7-AIII) the seventh amino acid of angiotensin III (phe) is replaced with isoleucine. [Ile7]-Angiotensin III (Ile7 AIII) is an angiotensin III (A III) receptor antagonist used to selectively block the action of Angiotensin III.
[Ile7]-Angiotensin III is (Ile7-Ang III) used as a peptide angiotensin receptor antagonist often in comparison with other Ang antagonists such as saralasin.
A6277 [Val4]-Angiotensin III acetate salt hydrate ≥97% (HPLC)  
A2562 Angiotensinogen from human plasma ≥80% (SDS-PAGE), lyophilized powder Angiotensinogen (renin substrate), a component of the rennin-angiotensin system, is a precursor protein to a family of blood pressure and hormone release regulating peptides known as the angiotensins.
A2283 Angiotensinogen from porcine plasma lyophilized powder, 1,500-3,000 units/g protein  
A6469 Apelin-13 trifluoroacetate salt ≥95% Synthetic endogenous peptide agonist for the human APJ receptor, a putative receptor protein related to the angiotensin receptor (AT1). This peptide exerted an acidification-rate-promoting activity in CHO cells expressing the APJ receptor with a median effective concentration (EC50) value of 0.37 nM. Blocks HIV-1 and HIV-2 entry into cells expressing the APJ receptor.
BM0030 BMS-248360 ≥98% (HPLC) BMS-248360 is an orally active dual antagonist of angiotensin II subtype 1 (AT1) and endothelin subtype A (ETA) receptors. BMS-248360 exhibited a broader spectrum of antihypertensive activity when compared to individual AT1 or ETA receptor antagonists.
C160 CGP-42112A ≥95%, synthetic, solid Potent AT2 angiotensin II receptor agonist.
SML0142 Valsartan ≥98% (HPLC) Valsartan is an Angiotensin II type 1 (AT1) receptor antagonist and anti-hypertensive. Valsartan renders protection against heart attack and stroke resulting from abrupt increase in blood pressure. Valsartan reduces myocardial-infarction-related complications in heart attack survivors.