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Cathepsin B

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A6191 Antipain dihydrochloride from microbial source protease inhibitor Reversible inhibitor of serine/cysteine proteases and some trypsin-like serine proteases. Its action resembles leupeptin; however, its plasmin inhibition is less and its cathepsin A inhibition is more than that observed with leupeptin. Chronic administration of antipain can reduce the frequency of chemically induced transformation in BALB/c-/3T3 cells.
C5732 CA-074 ≥99% (TLC)  
C5857 CA-074 methyl ester ≥99% (TLC) CA-074 methyl ester is an inhibitor of cathepsin B.
A6185 Calpain Inhibitor I ≥97% (TLC), powder Can initiate apoptosis in HL-60 cells but blocks dexamethasone-induced apoptosis in thymocytes and cycloheximide-induced apoptosis in metamyelocytes. Inhibits cyclin B degradation and arrests the cell cycle at G1/S and at meta-/anaphase. Blocks induction of nitric oxide synthase by LPS in macrophages.
A6060 Calpain Inhibitor II powder  
C7268 Chymostatin microbial Chymostatin is a strong inhibitor of many proteases, including chymotrypsin, papain, chymotrypsin-like serine proteinases, chymases, and lysosomal cysteine proteinases such as cathepsins A,B,C, B, H, and L. It weakly inhibits human leucocyte elastase. It is effective at a final concentration of 100 to 200 μg/ml (10 to 100 μM). Chymostatin is often included in protease inhibitor cocktails used with plant extracts.
Inhibits the lysosomal proteinase cathepsin B, and the soluble Ca2+-activated proteinase. Many young plant tissues express a chomostatin-sensitive serine protease.
C0408 Cystatin from chicken egg white buffered aqueous glycerol solution  
C8917 Cystatin from chicken egg white lyophilized powder  
C2749 Cystatin C human recombinant, expressed in Pichia pastoris  
E3132 E-64 protease inhibitor E-64 is an irreversible, potent, and highly selective cysteine protease inhibitor. E-64 does not react with the functional thiol group of non-protease enzymes, such as L-lactate dehydrogenase or creatine kinase. E-64 will not inhibit serine proteases (except trypsin) like other cysteine protease inhibitors, leupeptin and antipain. The trans-epoxysuccinyl group (active moiety) of E-64 irreversibly binds to an active thiol group in many cysteine proteases, such as papain, actinidase, and cathepsins B, H, and L to form a thioether linkage. E-64 is a very useful cysteine protease inhibitor for use in in vivo studies because it has a specific inhibition, it is permeable in cells and tissues and has low toxicity.
L2023 Leupeptin trifluoroacetate salt ≥90% (HPLC), microbial Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)
P0350 Procathepsin B Fragment 26-50, rat ≥95% (HPLC) Cathepsin B inhibitor.
C8984 Z-Leu-Leu-Leu-fluoromethyl ketone ≥90% (TLC) Z-Leu-Leu-Leu-fluoromethyl ketone is a proteosome inhibitor.
C9109 Z-Phe-Phe-fluoromethyl ketone ≥98% (TLC), solid