Attention:

Certain features of Sigma-Aldrich.com will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

Precursors

Endothelin

The three endothelins are synthesized as pre-proendothelins about 200 amino acids in length, and processed proteolytically to the final-21 residue, doubly disulfide bonded active peptide. The sequence of active endothelin is highly conserved. It is the amino terminal end of the 38 or 39 residue pro-endothelin molecule, termed big endothelin. Big endothelin is cleaved between trp21 and val22 by several proteinases. At this time we offer human and rat 38- and 39- big endothelins, respectively.

Product #

Description

Biochem/physiol Actions

Add to Cart

E7265 Big Endothelin 39 rat ≥97% (HPLC) Precursor of Endothelin-1; vasoconstrictor activity appears to be due to its conversion to endothelin 1 by endothelin converting enzyme in the tissue.