Immunomodulators

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SML0102 Bac2A trifluoroacetate salt ≥98% (HPLC) Bac2A is an antimicrobial and immunomodulatory peptide. Bac2A is a linear variant of bactenecin. Recent studies show that Bac2A is very effective against fungal pathogens, Fusarium oxysporum f. sp. vasinfectum and Fusarium graminearum. In these studies, Bac2A antifungal activity was not due to membrane destabilization but rather to interaction with intracellular targets.
C3662 Cyclosporin A from Tolypocladium inflatum, ≥95% (HPLC), solid A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
C1832 Cyclosporin A from Tolypocladium inflatum, BioReagent, for molecular biology, ≥95% A fungal metabolite possessing potent immunosuppressive properties. It inhibits the T-cell receptor signal transduction pathway via the formation of cyclosporin A−cyclophilin complex that inhibits calcineurin (protein phosphatase 2B). Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. Can block cytochrome c release from mitochondria.
Cyclosporin A has been shown to inhibit the functioning of several nuclear proteins involved in T-cell activation at the level of mRNA transcription. It forms a complex with its intracellular receptor cyclophilin, which can then bind to calcineurin, a Ca2+ - and calmodulin-dependent protein phosphatase, inhibiting its enzymatic activity. It was found to suppress the replication of hepatitis C virus genome in cultured hepatocytes.
H8409 Hymenistatin I >99% (HPLC) Exerts an immunosuppressive effect on humoral and cellular immune responses similar to cyclosporin A.
T3410 Thymosin α1 bovine ≥90% (HPLC) Hormone produced by thymic stromal cells that can augment host defense mechanisms, by increasing the production of T cells by thymus and restoring T cell-mediated antibody production in immunodeficient animals..
T5080 Thymulin lyophilized powder Thymulin also refers as serum thymic factor is a nonapeptide that reduces the hyperalgesia induced due to peripheral endotoxin administration in rats and mice. It also possesses an immunomodulator function by regulating the cytokine production by peripheral blood mononuclear cells (PBMC).
Thymulin, also known as Thymic Factor, is a nonapeptide produced by epithelial cell popuation in the thymus. This peptide is known for its immunomodulatory role and has neuroendocrine effects as well.
C9359 Z-Ala-Ser-Thr-Asp(OMe)-fluoromethyl ketone ≥90% (TLC), solid Cell-permeable inhibitor of endothelial monocyte-activating polypeptide II (EMAP-II).