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Potassium Channel Modulators

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Description

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A1289 Apamin from bee venom, ≥95% (HPLC) The only polypeptide neurotoxin that is known to pass the blood-brain barrier. Blocks ATP-type Ca+2-activated K+ channels.
A9459 Apamin synthetic, ≥97% (HPLC) The only polypeptide neurotoxin that is known to pass the blood-brain barrier. Blocks ATP-type Ca+2-activated K+ channels.
C7802 Charybdotoxin ≥90% (HPLC) High (BK) or intermediate (IK1) conductance calcium-activated and voltage-gated (Kv1.3) channel blocker.
Potent and selective inhibitor of the Ca2+-activated K+ channel present in GH3 anterior pituitary cells and primary bovine aortic smooth muscle cells.
C8089 [Gln12]-Charybdotoxin ≥85%  
C7839 [His19]-Charybdotoxin ≥85%  
C5856 Charybdotoxin, recombinant from Leiurus quinquestriatus hebraeus recombinant, expressed in E. coli, lyophilized powder Exhibits the same activity as the natural form of the toxin
M8278 Margatoxin ≥90% (HPLC) Specific K(V)1.3 channel voltage-dependent K+ channel blocker
T8316 Tertiapin >95% A potent inhibitor of the inward-rectifier K+ channels, blocked a G-protein-gated channel (GIRK1/4) and the ROMK1 channel with nanomolar affinities, however a closely related channel, IRK1, was insensitive to tertiapin. Thus, tertiapin is a tool for purifying functional channels as well as for screening pharmaceutical agents against these channels.
Tertiapin is a peptide isolated from honey bee venom, which is a selective IKACh blocker that prolongs the atrial effective refractory period and terminates the atrial fibrillation. It is a selective and potent inhibitor of muscarinic K+ channels in rabbit cardiac myocytes.
T1567 Tertiapin-Q trifluoroacetate salt ≥97% (HPLC) Blocks the GIRK1/4 and ROMK1 members of the inward-rectifier K+ channel family.