Attention:

Certain features of Sigma-Aldrich.com will be down for maintenance the evening of Friday August 18th starting at 8:00 pm CDT until Saturday August 19th at 12:01 pm CDT.   Please note that you still have telephone and email access to our local offices. We apologize for any inconvenience.

Parathyroid Hormone Fragments

Parathyroid hormone is an 84 amino-acid peptide that regulates free calcium concentration in the circulation. The hormone is stored in granules, and released from the parathyroid glands when a G-protein linked calcium receptor detects lowering of blood calcium supplies. Parathyroid hormone works by three mechanisms to increase calcium availability:

1.It initiates a chain of events resulting in bone breakdown by osteoclasts.
2.It causes the distal tubules of the kidney to enhance reabsorption of calcium while reducing the reabsorption of phosphate.
3.It causes the kidney to complete vitamin D activation. Vitamin D promotes uptake of food-derived calcium in the gut.

The 34 amino-terminal residues of the hormone are responsible for binding to the tissue receptors, and this fragment can substitute for the complete molecule. We offer the human, bovine, and rat fragments 1-34, as well as very pure bovine and human parathyroid hormones.
We also offer N-terminal fragments of the hypercalcemia of malignancy protein that is partially homologous to parathyroid hormone and has similar activities. Carboxyl-terminal fragments of parathyroid hormone, known to accumulate in renal disease, are also available.

Product #

Description

Biochem/physiol Actions

Add to Cart

H9148 Hypercalcemia of malignancy factor fragment 1-34 amide human ≥97% (HPLC) Hypercalcemia of malignancy factor fragment 1-34 amide human is a parathyroid hormone-like protein (PLP) fragment used to study parathyroid hormone-related signaling pathways.
H4644 Hypercalcemia of malignancy factor 1-40 human ≥95% (HPLC) Hypercalcemia of malignancy factor fragment 1-40 human is a parathyroid hormone-like protein (PLP) fragment used to study parathyroid hormone-related signaling pathways.
P5028 Parathyroid hormone from bovine parathyroid  
P7036 Parathyroid hormone human ≥95% (HPLC), powder  
P2780 Parathyroid Hormone Fragment 13-34 human ≥95% (HPLC)  
P3671 Parathyroid Hormone Fragment 1-34 bovine ≥97% (HPLC), powder  
P3796 Parathyroid Hormone Fragment 1-34 human ≥95% (HPLC), powder Parathyroid hormone (PTH) is a parathyroid-secreted polypeptide hormone that increases the level of calcium in blood by enhancing calcium mobilization from bone, increasing the calcium:phosphate ratio in the kidney and promoting the absorption of calcium by the intestines. PTH is an anabolic agent that improves osteoblastic bone development. PTH 1-34 induces bone morphogenetic protein (BMP) gene transcription. Active N-terminal fragment of PTH (residues 1–34), has been used as a therapeutic for postmenopausal women with osteoporosis who are at high risk for fracture.
P3613 [Cys8]-Parathyroid Hormone Fragment 1-8 human >90% (HPLC), solid  
P3921 Parathyroid Hormone Fragment 1-34 rat ≥97% (HPLC), powder  
P2905 [Nle8,18, Tyr34]-PTH Fragment 1-34 amide bovine ≥97% (HPLC)  
P6157 [Asp76]-PTH Fragment 64-84 human ≥95% (HPLC)  
S3884 Sauvagine ≥97% (HPLC) A peptide related to CRF and urotensin 1 that was first isolated from the skin of the frog Phyllomedusa sauvagei. Potent releaser of ACTH and β-endorphin from the anterior pituitary.