Somatostatins

Somatostatin is a cyclic peptide hormone that inhibits the release of many other hormones and bioactive proteins. First described as a hypothalamic molecule that inhibits release of growth hormone from the anterior pituitary, somatostain has subsequently been found to also inhibit release of ACTH and thyroid stimulating hormone. Somatostatin is found throughout the body, mostly in central and peripheral nervous tissue, and in the gastrointestinal tract and pancreas.

Pancreatic somatostatin inhibits insulin and glucagon release. When secreted by paracrine cells distributed through the length of the gastrointestinal tract it inhibits secretion of various digestive hormones such as gastrin, secretin, and peptide YY. Since the five G-protein coupled somatostatin receptors have tissue-specific distribution patterns and differing affinities for the two forms of the hormone, effects vary widely. Active somatostatin is processed from a pre-prohormone into two disulfide bridged cyclic forms. We offer both somatostatin 14, and somatostatin 28, which has a peptide chain amino-terminal to the somatostatin-14 portion. Somatostatin is available as BioXtra and BioReagent formulations suitable for cell culture applications.

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C4801 Cyclo(7-aminoheptanoyl-Phe-D-Trp-Lys-Thr[Bzl]) ≥95% (HPLC), powder Somatostatin antagonist.
S9129 Somatostatin ≥97% (HPLC), powder Somatostatin regulates the secretion of hormones and bioactive peptides. It acts as an inhibitor in the digestive tract by inhibiting gastrin release. In the pancreatic islets, it inhibits glucagon and insulin release. Somatostatin and its synthetic analogs have been used in the treatment of neuroendocrine tumors.
S1763 Somatostatin powder, BioReagent, suitable for cell culture Somatostatin regulates the endocrine system and affects neurotransmission and cell proliferation via interaction with G protein-coupled somatostatin receptors and inhibition of the release of numerous secondary hormones.
S0885 Somatostatin powder, γ-irradiated, BioXtra, suitable for cell culture Somatostatin regulates endocrine function and cell proliferation via interaction with G-protein-coupled somatostatin receptors. It exists in two active forms produced by alternative cleavage of a single preproprotein (14 aa and 28 aa forms). Somatosatin inhibits the release of growth hormone; thyroid-stimulating hormone and a range of gastrointestinal hormones: Cholecystokinin (CCK); Enteroglucagon; Gastrin; Gastric inhibitory polypeptide (GIP); Motilin; Secretin; Vasoactive intestinal peptide (VIP).
S6135 Somatostatin 28 ≥97% (HPLC) Mediates inhibition of peptide YY secretion from rat intestinal cultures.
S9313 Somatostatin Fragment 2-9 ≥97% (HPLC), solid  
S9438 Somatostatin Fragment 3-10 ≥96% (HPLC), solid