Vasopressins

Vasopressin is a cyclic nonapeptide endocrine hormone synthesized as a prohormone in the hypothalamus and secreted to the circulation from the posterior pituitary. Its alternate name, anti-diuretic hormone (ADH), describes its best-known function. When receptors in the hypothalamus sense high osmolarity or low volume in the blood, vasopressin is released. Upon hormone binding to V2 receptors in the kidney collecting ducts, aquaporin water channels move to the cell membrane and allow water to be reabsorbed. This molecule is named vasopressin because it binds to V1a receptors in the vasculature to cause smooth muscle contraction. A third type of vasopressin receptor, V1b, occurs in brain tissue and is involved with the secretion of ACTH in response to stress and other neurological responses. We offer specific agonists and antagonists to the three receptors, enabling the researcher to study the vasopressin effect of interest. In addition, copeptin, the carboxyl-terminal fragment of the prohormone, serves as a diagnostic marker for several diseases such as sepsis because of its stability relative to vasopressin. We list both Arg-vasopressin, the form found in humans and most mammals, as well as Lys-vasopressin, found in pigs and marsupials.

Product #

Description

Biochem/physiol Actions

Add to Cart

C8749 Copeptin trifluoroacetate human ≥95% (HPLC) Copeptin, the C-terminal part of the vasopressin prohormone is a stable and sensitive surrogate marker for AVP release. Copeptin, a 39-amino acid glycopeptide that comprises the C-terminal part of the Arginine vasopressin (AVP) precursor (CT-proAVP), is cosynthesized with AVP. AVP is a primary secretagogue of the hypothalamo–pituitary–adrenal axis, a key hormone for maintaining fluid balance and vascular tone, and is a marker of acute endogenous stress. However, it has a short half-life and measurement of mature AVP is difficult and subject to errors. Copeptin in contrast is stable and easily measured.
V2381 [Adamantaneacetyl1, O-Et-D-Tyr2, Val4, Aminobutyryl6, Arg8,9]-Vasopressin ≥95% (HPLC) [Adamantaneacetyl1, O-Et-D-Tyr2, Val4, Aminobutyryl6, Arg8,9]-Vasopressin is a V2 antagonist that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It can also stimulate three acid-base transporters and hence increases the capability of the cell to regulate pHi. Additionally, vasopressin can induce anion secretion by Human and Porcine Vas Deferens Epithelia.
V9879 [Arg8]-Vasopressin acetate salt ≥95% (HPLC) Endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. Arg8-vasopressin is also a neurotransmitter in the central nervous system. It is implicated in a variety of physiological processes including diuresis, vasoregulation, and memory. Regulates water balance by antidiuretic action; contracts arterioles (vasopressor action).
V0377 [Arg8]-Vasopressin solution Grade VI (synthetic), ~100 I.U./mL in 0.9% NaCl Endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. Arg8-vasopressin is also a neurotransmitter in the central nervous system. It is implicated in a variety of physiological processes including diuresis, vasoregulation, and memory. Regulates water balance by antidiuretic action; contracts arterioles (vasopressor action).
[Arg8]-Vasopressin solution also known as Antidiuretic hormone, Arginine vasopressin or beta-Hypophamine is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It stimulates three acid-base transporters and hence increases the capability of the cell to regulate pH.
V1005 [deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate ≥97% (HPLC) [deamino-Cys1, D-Arg8]-Vasopressin acetate salt hydrate also known as DDAVP, Desmopressin is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It also stimulate three acid-base transporters and hence increases the capability of the cell to regulate pH.
V2013 [deamino-Cys1, Val4, D-Arg8]-Vasopressin ≥95% [Deamino-Pen1, O-Me-Tyr2, Arg8]-Vasopressin is a V1 antagonist that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock.It can also stimulate three acid-base transporters and hence increases the capability of the cell to regulate pHi.
V1880 [deamino-Pen1, O-Me-Tyr2, Arg8]-Vasopressin ≥97% (HPLC) [Deamino-Pen1, O-Me-Tyr2, Arg8]-Vasopressin is a V1 antagonist that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It also stimulates three acid-base transporters and hence increases the capability of the cell to regulate pHi.
V6879 [Lys8]-Vasopressin ≥98% (HPLC) Predominant form of vasopressin present in pigs and marsupials. It has lower vasopressor and antidiuretic activity than Arg8-vasopressin.
[Lys8]-Vasopressin also refers as Lysine vasopressin or Lyspressin is the predominant form of vasopressin present in pigs and marsupials. It antagonizes the amnesia in rats. Lyspressin can also induce resistance to extinction of active avoidance behaviour.
V4253 [β-Mercapto-β,β-cyclopentamethylenepropionyl1, O-Et-Tyr2, Val4, Arg8]-Vasopressin ≥97% (HPLC) Vasopressin also known as antidiuretic hormone (ADH) or argipressin can stimulate three acid-base transporters and hence increases the capability of the cell to regulate pHi.ADH can induce reversible translocation of aquaporin-CD water channels from intracellular vesicles to apical plasma membrane, which in turn increases the water permeability of collecting duct cells.
V2255 [β-Mercapto-β,β-cyclopentamethylenepropionyl1, O-me-Tyr2, Arg8]-Vasopressin ≥97% (HPLC) [Beta-Mercapto-beta,beta-cyclopentamethylenepropionyl1, O-me-Tyr2, Arg8]-Vasopressin is a V1a vasopressin receptor antagonist also referred to as “Manning compound”. Vasopressin can stimulate three acid-base transporters and hence increases the capability of the cell to regulate pHi. It induces reversible translocation of aquaporin-CD water channels from intracellular vesicles to apical plasma membrane, which increases the water permeability of collecting duct cells.
V2138 [Phenylacetyl1, O-Me-D-Tyr2, Arg6,8, Lys9]-Vasopressin amide >98% (HPLC), solid Phenylacetyl1, O-Me-D-Tyr2, Arg6,8, Lys9]-Vasopressin amide is a selective antagonist with high affinity for the V-1a vasopressin receptors. Vasopressin can stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock.It can also stimulate three acid-base transporters and hence increases the capability of the cell to regulate pHi. Additionally, it can induce reversible translocation of aquaporin-CD water channels from intracellular vesicles to apical plasma membrane, which in turn increases the water permeability of collecting duct cells.
Selective antagonist having an extremely high affinity for the V-1a vasopressin receptors.