Miscellaneous Neuropeptides

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SML0395 Ac-EEMQRR-NH2 trifluoroacetate salt ≥95% (HPLC) Ac-EEMQRR-NH2 is a SNAP25 N-terminal-derived peptide that inhibits the SNARE complex and possibly blocks neuronal exocytosis. Ac-EEMQRR-NH2 exhibits anti-inflammatory and anti-wrinkle activity. It is used as anti-wrinkle cosmetics ingredient.
SML0729 BAM8-22 trifluoroacetate salt ≥98% (HPLC) BAM8-22 is a selective agonist for the sensory neuron specific G-protein coupled receptors (SNSRs). BAM8-22 inhibits development of morphine tolerance in rats. BAM8-22 is inactive at opioid receptors. Also, BAM8–22 is a potent activator of Mas-related G-protein-coupled receptors (Mrgprs), MrgprC11 and hMrgprX1. BAM8-22 produces itch and nociceptive sensations in humans in a histamine-independent manner.
C6249 Catestatin The catestatin peptide is produced from its precursor chromogranin A protein. Catestatin is a cationic and hydrophobic peptide that can stimulate histamine release from mast cells and exhibits potent catecholamine relase-inhibitory activity.
C8624 COG 133 trifluoroacetate salt ≥95% (HPLC) COG 1333 or apoE(133-149) is a fragment of Apolipoprotein E (APOE) that mimics the functional anti-inflammatory and neuroprotective effects of the intact apoE protein. It was suggested that neuroprotective functions of the mimetic results from binding to the low-density lipoprotein receptor-related protein (LRP) or LDL receptors, and such binding results in inhibition of the N-methyl-D-aspartate (NMDA) receptor.
G5149 Gly-Gln monohydrate ≥97% (HPLC) Gly-Gln monohydrate has been used for the preparation of glutamine solution in HTF (human tubal fluid) medium to assess the accumulation of ammonium in commercially available culture media and protein supplements for in vitro development of human pre-implantation embryos, when stored at 2–8°C and incubated at 37°C.
M5167 Myelin Basic Protein Guinea Pig Fragment 68-82 ≥97% (HPLC) Myelin basic protein fragment that induces experimental allergic encephalomyelitis.
M3755 Myelin Basic Protein Guinea Pig Fragment 68-82 ≥97% (HPLC) Myelin basic protein fragment that induces experimental allergic encephalomyelitis.
M4449 Myelin Oligodendrocyte Glycoprotein (35-55), Human lyophilized powder This is a truncated peptide from the human Myelin Oligodendrocyte Glycoprotein (MOG) responsible for the induction of experimental autoimmune encephalomyelitis in mouse and rat models for human multiple sclerosis research.
M4939 Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 Rat, Mouse immunodominant epitope of MOG Induces experimental autoimmune encephalomyelitis in rodents; a single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination; immunization with MOG (35-55) suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP.
Myelin Oligodendrocyte Glycoprotein Peptide Fragment 35-55 induces experimental autoimmune encephalomyelitis in rodents; a single injection of this peptide produces a relapsing-remitting neurologic disease with extensive plaque-like demyelination; immunization with MOG (35-55) suppresses spontaneous regeneration of dopaminergic neurons injured with MPTP.
M4199 Myelin Oligodendrocyte Glycoprotein (40-54), Rat, Mouse lyophilized powder The 21-residue peptide MOG 35-55 contains an antigenic epitope responsible for the activation of CD8 encephalitogenic T cells in mice. Two truncated peptides, MOG 40-54 and MOG 44-54 were shown to bind the recombinant H-2Db protein. This complex then binds MOG specific CD8 T cells. While MOG 40-54 retained the full capability of inducing paralytic disease, MOG 44-54 only partialy causes clinical paralysis and central nervous system inflamation.
M4324 Myelin Oligodendrocyte Glycoprotein (44-54), Rat, Mouse lyophilized powder The 21-residue peptide MOG 35-55 contains an antigenic epitope responsible for the activation of CD8 encephalitogenic T cells in mice. Two truncated peptides, MOG 40-54 and MOG 44-54 were shown to bind the recombinant H-2Db protein. This complex then binds MOG specific CD8 T cells. While MOG 40-54 retained the full capability of inducing paralytic disease, MOG 44-54 only partialy causes clinical paralysis and central nervous system inflamation.
N2412 Neuropeptide S from rat ≥98% (HPLC), powder Neuropeptide S is a novel modulator of wakefulness and anxiety.
S7065 Secretoneurin mouse, rat trifluoroacetate salt Neuropeptide generated in brain, adrenal medulla and other endocrine tissues by proteolytic processing of secretogranin II (chromogranin C). Endogenous peptide that enhances dopamine release.
SML1459 SHA 68 ≥98% (HPLC) SHA 68 is a potent and selective neuropeptide S receptor antagonist that exhibits anxiogenic effects.
W2895 WE-14 trifluoroacetate salt ≥98% (HPLC) WE-14 peptide is a highly conserved neuropeptide derived from Chromogranin A (Parathyroid Secretory Protein 1). It has been detected in vertebrate and invertebrate neurons and in vertebrate endocrine tissues, most notably in the adrenal, pituitary, and parathyroid glands, and has also been found in human and bovine gastro-entero-pancreatic tissues.