Antagonist

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A5330 N-Acetyl-L-tryptophan 3,5-bis(trifluoromethyl)benzyl ester ≥99% (TLC), powder Competitive substance P receptor antagonist. It is approximately 1000-fold more potent at cloned human NK-1 receptors than at cloned human NK-2 and NK-3 receptors; and approximately 200-fold more potent at human NK-1 receptors than at rat NK-1 receptors. The IC50 for the human NK-1 receptor expressed in CHO cells is approximately 2 nM.
    • G115 GR 82334 ≥95% Potent and specific reversible antagonist at the NK-1 tachykinin receptor.
    • G130 GR 94800 >96%, powder Selective NK-2 tachykinin receptor antagonist.
    • L117 L-659,877 >95%, powder Potent and selective NK-2 tachykinin receptor antagonist.
    • M157 MEN-10,376 ≥95% (HPLC), solid Potent and selective NK-2 tachykinin receptor antagonist.
    • S3144 [D-Arg1, D-Phe5, D-Trp7,9, Leu11]-Substance P ≥95% (HPLC) NK-1 tachykinin receptor antagonist
    • S4152 [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-Substance P acetate salt ≥97% (HPLC) Substance P antagonist
    • S3641 [D-Arg1, D-Trp7,9, Leu11]-Substance P ≥97% (HPLC) Potent substance P antagonist with weak histamine-releasing action
    • S5635 [D-Pro2, D-Phe7, D-Trp9]-Substance P ≥95% (HPLC) Substance P antagonist
    • S0145 [D-Pro2, D-Trp7,9]-Substance P acetate salt ≥97% (HPLC) Substance P antagonist
    • S8031 [pGlu5, D-Trp7,9,10]-Substance P Fragment 5-11 ≥90% (HPLC)