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P9953 L-α-Phosphatidyl-D-myo-inositol 3,4,5-triphosphate, dioctanoyl Signaling lipid; activates PDK1 (3-phosphoinositide-dependent protein kinase), which is necessary, but not sufficient, for the activation of PKB/Akt. PDK1 also phosphorylates and activates p70S6k.