Matrix metalloproteinase

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M6412 7-Methoxycoumarin-4-acetyl-Pro-Leu-Gly-Leu-β-(2,4-dinitrophenylamino)Ala-Arg amide ≥97% (HPLC)  
SCP0189 MMP 13 Substrate, fluorogenic ≥98% (HPLC)  
SCP0192 MMP 2 Substrate, fluorogenic ≥98% (HPLC)  
SCP0194 MMP 3 Substrate ≥98% (HPLC)  
SCP0188 MMP 8 Substrate ≥95% (HPLC)  
SCP0191 MMP 2 / MMP 9 Substrate ≥97% (HPLC)  
SCP0190 MMP 14 (Stomelysin-3) Substrate ≥97% (HPLC)  
SCP0193 MMP Substrate ≥97% (HPLC) The peptide MCA-Lys-Pro-Leu-Gly-Leu-DNP-Dpa-Ala-Arg-NH2, or FS-6, is a fluorogenic substrate for several matrix metalloproteinases (MMPs). FS-6 is a water-soluble, modified form of the well-established MMP substrate FS-1, where a lysine residue has been added to the N-terminus of FS-1. The resulting FS-6 has been reported to give a peptide with improved kinetic properties for several MMPs, including MMP-1, MMP-8, MMP-13, and MMP-14, compared to FS-1. This MMP substrate has also been described as a particularly useful substrate for the zinc metalloproteinase tumor necrosis factor-α converting enzyme (TACE or ADAM-17). FS-6 can be used to measure metalloproteinase activity in tissue culture conditions, for example, on the surface of viable cells in situ.