Cyclins and Nuclear Proteins

Cyclins are conserved proteins (cyclin box) that have no activity on their own unless they are bound to cyclin-dependent kinases (Cdks). This binding initiates the phosphorylation of specific proteins responsible for controlling specific steps in the cell cycle progression, including apoptosis. Cyclin concentration rises and falls through the different phases of the cell cycle (resting, interphase and cell division). Another nuclear protein important in apoptosis research is p53, a highly conserved tumor suppressor gene found in normal tissues. P53 is the most commonly mutated gene causing cancer, including malignancies, hematologic and solid tumors. Intact p53 function is essential for the maintenance of the non-tumorogenic phenotype of cells, and suppressing cancer. Nuclear proteins are important for elucidating gene expression, RNA processing, organ development, and other cellular processes.

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SRP5343 CyclinA2, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
SRP5346 CyclinC, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
SRP5345 CyclinE1, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
SRP5344 CyclinK, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
P6249 p53 human recombinant, expressed in E. coli, buffered aqueous glycerol solution
P6374 p53 human recombinant, expressed in baculovirus infected Sf21 cells
SRP4832 p53 Mutant human recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)
SRP4835 PCNA human recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE), ≥90% (HPLC)
P4480 PSTAIRE peptide ≥95% (HPLC)
T8455 Tyrosinase Fragment 369-377 human
SRP0418 WDR5 human recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE)
SRP0480 WDR9 (1308-1436) human recombinant, expressed in E. coli, ≥82% (SDS-PAGE)
W4387 Wee1, active from rat N-terminal GST-tagged, solution