| C5923 | (−)-Cotinine ~98% | Major metabolite of nicotine in humans.
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| N5260 | (−)-Nicotine hydrogen tartrate salt ≥98% (TLC), powder | Prototype nicotinic acetylcholine receptor agonist; naturally occurring isomer.
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| A5656 | (±)-Anabasine ≥90% (TLC), liquid | Tobacco alkaloid; potent nicotinic acetylcholine receptor agonist.
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| E1145 | (±)-Epibatidine dihydrochloride hydrate ≥98% (HPLC), powder | The activity of epibatidine at neuronal and neuromuscular nicotinic acetylcholine receptors was compared with the activity of nicotine and suxamethonium. Activation of ganglionic nicotinic receptors by epibatidine was shown in the guinea-pig ileum (contraction mediated by the cholinergic neurons of the ileum) and in pithed and atropinized rats (rise in blood pressure). Epibatidine also activated nicotinic receptors at the peripheral terminals of afferent C-fibres (rabbit ear) and in the brain (antidiuresis in rats). The agonistic effects of epibatidine were followed by long-lasting receptor desensitization. No antinociceptive effect of epibatidine was seen in rats at a dose free of motor impairment. On muscle end plate nicotinic receptors of the rat diaphragm (not responding to depolarizing agents by contraction), epibatidine was equipotent with suxamethonium in causing neuromuscular inhibition. On an extraocular muscle of the rabbit (responding to depolarizing agents by contraction) epibatidine in vitro and in situ caused a contraction at a 100-fold lower dose than suxamethonium. The Straub tail reaction in mice to epibatidine could be attributed to the sustained stimulation of motor end plate receptors of the "slow contracting" type of muscle fibres by epibatidine. Epibatidine was the most potent agonist on all neuronal and neuromuscular nicotinic receptors examined.
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| N0267 | (±)-Nicotine ≥98% (TLC), liquid | Prototype nicotinic acetylcholine receptor agonist.
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| N3018 | (±)-Nornicotine ≥99% (TLC), liquid | Nicotinic acetylcholine receptor agonist; active metabolite of nicotine; tobacco alkaloid.
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| E0280 | (+)-Epibatidine dihydrochloride ≥98% (HPLC), solid | (+)-Epibatidine is a non-opioid analgesic alkaloid isolated from skin of Ecuadoran tree frog, Epipedobates tricolor; naturally-occurring isomer of the most potent nicotinic acetylcholine receptor agonist known. Discoveries in the nAChR field have stimulated interest in nAChR-targeted compounds as potential analgesic agents. Epibatidine has full efficacy relative to opioids in preclinical pain models. Although epibatidine is toxic, these observations demonstrated that modest efficacy is not a general limitation of nAChR agonists. Moreover, exploration of the molecular biology of nAChRs revealed evidence of receptor diversity, suggesting that nAChR subtype-selective agents are less toxic than nicotine; and early medicinal chemistry efforts have resulted in compounds with improved safety profiles.
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| T2379 | (+)-Tubocurarine chloride hydrate ≥97% | Muscle relaxant; nicotinic acetylcholine receptor antagonist; can induce neuromuscular paralysis.
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| D5891 | 1,1-Dimethyl-4-phenylpiperazinium iodide ≥98% (TLC or titration), powder | Nicotinic acetylcholine receptor agonist.
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| A251 | A-85380 dihydrochloride solid | Potent and selective neuronal nicotinic acetylcholine receptor (nAChR) agonist.
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| A6476 | ABT-418 hydrochloride powder, ≥98% (HPLC) | Neuronal nicotinic acetylcholine receptor agonist with cognition enhancing and anxiolytic activities.
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| A6625 | Acetylcholine chloride ≥99% (TLC) | Endogenous neurotransmitter at cholinergic synapses; amplifies action potential of the sarcolemma thereby inducing muscle contractions.
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| A5751 | Acetylthiocholine iodide ≥98% (TLC), powder | | pricing |
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| A7604 | Atracurium besylate ≥98% (HPLC), powder | Nicotinic acetylcholine receptor antagonist.
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| B121 | Bromoacetylcholine bromide | | pricing |
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| C5366 | Chlorisondamine diiodide ≥98% (HPLC), white solid | Irreversible, long-lasting nicotinic acetylcholine receptor antagonist.
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| C2108 | Condelphine 95%, solid | Nicotinic acetylcholine receptor antagonist.
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| C2899 | Cytisine ≥99%, powder | Potent agonist at α3β4 and α7 nicotinic acetylcholine receptors and partial agonist at α4β2 nicotinic acetylcholine receptors.
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| D7938 | DBO-83 solid | Novel nicotinic acetylcholine receptor agonist, structurally related to epibatidine, with antinociceptive properties in rodents.
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| D1260 | Decamethonium bromide crystalline | Nicotinic acetylcholine receptor partial agonist and neuromuscular blocking agent; depolarizes striated muscles and blocks their activity.
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| D6939 | Delcorine ≥97% (TLC), solid | Antiarrhythmic and hypotensive; ganglion blocker; exhibits weak affinity at brain α-bungarotoxin-sensitive nicotinic acetylcholine receptors.
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| D149 | Dihydro-β-erythroidine hydrobromide solid | Competitive nicotinic receptor antagonist.
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| D7689 | Diquine ≥98%, solid | A nicotinic cholinoreceptor antagonist at the neuromuscular junction; curare-like ganglioblocker.
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| F6301 | Fluorocurarine chloride ≥97% (TLC), from Vinca erecta, solid | Short-acting selective sympathetic ganglioblocker with weak antagonist activity on the nicotinic receptor at the neuromuscular junction; hypotensive.
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| H0879 | Hexamethonium bromide | Preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier only at high doses.
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| L134 | Linopirdine ≥98% (HPLC) | Stimulates release of acetylcholine and other neurotransmitters; cognitive enhancer.
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| M3184 | MG 624 ≥98% | Nicotinic acetylcholine receptor antagonist; selectively inhibits neuronal nicotinic α-bungarotoxin sensitive receptors that contain the α7 subunit.
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| M9020 | Mecamylamine hydrochloride | Noncompetitive nicotinic acetylcholine receptor antagonist; preferentially blocks nicotinic receptors at autonomic ganglia; crosses blood-brain barrier.
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| M168 | Methyllycaconitine citrate salt hydrate from Delphinium brownii seeds, ≥96% (HPLC) | Potent and specific nicotinic receptor antagonist that binds to neuronal α-bungarotoxin sites.
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| T6692 | N,N,N-Trimethyl-1-(4-trans-stilbenoxy)-2-propylammonium iodide | Nicotinic acetylcholine receptor antagonist.
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| N5537 | NDNI hydriodide solid, (The product is pure based on CHN, NMR, MS) | Highly selective α4β2 nicotinic receptor antagonist
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| P0043 | PNU-120596 ≥98% (HPLC) | PNU-120596 is a positive allosteric modulator of the α7 nicotinic acetylcholine receptor. PNU-120596 is representative of a novel class of allosteric modulators that enhances α7 function. PNU-120596 produces no detectable change in currents mediated by a4b2, a3b4, a9a10 nAchRs; increases channel mean open time, but has no effect on ion selectivity.
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| P1918 | Pancuronium bromide | Aminosteroidal neuromuscular blocking agent; skeletal muscle relaxant
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| P5114 | Pempidine tartrate ≥98% (TLC), powder | Neuronal nicotinic acetylcholine receptor antagonist; potent ganglioblocker; antihypertensive.
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| Q0255 | Quirestine ≥98% (TLC), powder | Nicotinic acetylcholine receptor antagonist. Potent short-acting ganglioblocker.
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| R131 | RJR-2429 dihydrochloride solid | Nicotinic acetylcholine receptor agonist.
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| R5155 | Rocuronium bromide | Aminosteroid; neuromuscular blocker for anaesthesia
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| T5576 | TMPH hydrochloride solid, (Product is pure based on CHN, NMR and MS results) | 2,2,6,6-tetramethylpiperidin-4-yl heptanoate (TMPH) is a potent inhibitor of neuronal nicotinic receptors. Evaluation of nicotinic acetylcholine receptor (nAChR) subunits expressed in Xenopus laevis oocytes indicated that TMPH can produce a potent and long-lasting inhibition of neuronal nAChR formed by the pairwise combination of the most abundant neuronal alpha (i.e., alpha3 and alpha4) and beta subunits (beta2 and beta4), with relatively little effect, because of rapid reversibility of inhibition, on muscle-type (alpha1beta1gammadelta) or alpha7 receptors. However, the inhibition of neuronal beta subunit-containing receptors was also decreased if any of the nonessential subunits alpha5, alpha6, or beta3 were coexpressed. This decrease in inhibition is shown to be associated with a single amino acid present in the second transmembrane domain of these subunits. TMPH abilitty to relate the diverse central nervous system effects to specific nAChR subtypes makes it a useful tool for studying the functional roles of nAChR.
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| T4569 | Temechine hydrobromide ≥98% (TLC), powder | Neuronal nicotinic acetylcholine receptor antagonist; potent ganglioblocker.
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| T4819 | Tempoxime hydrochloride ≥98% (TLC) | Neuronal nicotinic AChR antagonist and potent ganglioblocker.
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| T3019 | α-Bungarotoxin from Bungarus multicinctus (Formosan Banded Krait) solid | Neurotoxin which binds irreversibly to motor endplate of acetylcholine receptors; prevents opening of nicotinic receptor-associated ion channels.
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| T0195 | α-Bungarotoxin-tetramethylrhodamine from Bungarus multicinctus (Formosan Banded Krait) | Useful for detecting the distribution of nicotinic acetylcholine receptors at neuromuscular junctions.
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| C2461 | α-Conotoxin Im I ≥97% (HPLC) | Nicotinic acetylcholine receptor antagonist in central nervous system.
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