Urotensins

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A0355 AC-7954 ≥98% (HPLC), solid Nonpeptide GPR14 / urotensin-UII (UII) receptor agonist that has an EC50 of 300 nM at the human UII receptor (h-UTR). AC-7954 has been shown to exist in two conformations, A and B; both conformations have a pharmacophoric distance within 0.5 Å of P5U, a potent peptidic UII agonist.
S7326 SB 657510 ≥98% (HPLC) SB 657510 slows development of diabetes-associated atherosclerosis in mouse model of diabetes.1
SB-657510 is a selective urotensin-II (UT) receptor antagonist. Human urotensin-II (hU-II) is proposed to play a significant role in cardiorenal and metabolic disease states, including heart failure, atherosclerosis, hypertension.
U8132 [pGlu110]-Prepro-Urotensin II Fragment 110-123 rat >98% (HPLC), solid Potent vasoconstrictor.
Rat Urotensin II is a neuroendocrine peptide that belongs to CRF family and possesses regionally-selective vasodilator impact on conscious rats. It also induces potent vasoconstriction in humans in vivo.
U7257 Urotensin II human ≥97% (HPLC), synthetic A neuroendocrine peptide of the CRF family that was originally isolated from fish brain but is also found in mammalian brain and spinal motor neurons. It is a potent vasoconstrictor. It may be a mediator of stress-induced anorexia.
Human urotensin II is a vasoactive neuropeptide that belongs to CRF family and stimulates arterial smooth muscle contraction, actin stress fiber formation and proliferation via small GTPase RhoA and there downstream effector Rho-kinase activation.The product is also a selective and potent vasoconstrictor agent as well as an agonist for the orphan receptor GPR14.
U7507 Urotensin II rat ≥97% (HPLC), synthetic A neuroendocrine peptide of the CRF family that was originally isolated from fish brain but is also found in mammalian brain and spinal motor neurons. It is a potent vasoconstrictor. It may be a mediator of stress-induced anorexia.
Rat Urotensin II is a neuroendocrine peptide that belongs to CRF family and possesses regionally-selective vasodilator impact on conscious rats. It also induces potent vasoconstriction in humans in vivo.
U7253 Urotensin I teleost fish ≥95% (HPLC) A neuroendocrine peptide of the CRF family that is found in the brain of most fish species. It may be involved in the regulation of blood pressure in fish. It is closely related to mammalian urocortin and releases ACTH from cultured rat pituitary cells.
Urotensin I is a CRF-like neuropeptide, expresses mainly in the brain of most fish species. It induces the acetylcholine (ACTH) release from the superfused goldfish anterior pituitary cell column. It stimulates the marked, dose-dependent reduction in perfusion pressure in the hind limb of the rat.