| B0753 | 2,3-Butanedione monoxime reagent grade, ≥98% | DRK1 is a delayed rectifier (Kv2.1) cloned K+ channel from rat brain with consensus sites for protein kinase-dependent phosphorylation that might be expected to be functionally regulated by phosphorylation. 2,3-Butanedione monoxime (BDM) chemically removes phosphate groups from many proteins, and its action on DRK1 channels was examined after expression of DRK1 cRNA in Xenopus oocytes. In two-microelectrode voltage-clamp experiments, the application of 2,3-Butanedione monoxime to the bath inhibited DRK1 current (ki = 16.6 mM, H = 0.96) rapidly and reversibly, with a time course similar to the time course of solution change within the bath. DRK1 current was inhibited at all potentials; the time course of current activation, deactivation and inactivation were unaffected by 2,3-Butanedione monoxime. In inside-out patch-clamp experiments, the application of 2,3-Butanedione monoxime to the cytoplasmic surface similarly inhibited channel activity rapidly and reversibly (ki = 10.7 mM, H = 1.01) in the absence of rephosphorylating substrates. These results are inconsistent with a phosphatase effect, because such an effect should be irreversible in cell-free, ATP-free patches. Instead, the results suggest that 2,3-Butanedione monoxime can inhibit DRK1 channels directly from inside or outside of the membrane.
| pricing |
|
| B6936 | 3-Benzidino-6-(4-chlorophenyl)pyridazine ≥98% (HPLC), solid | 3-Benzidino-6-(4-chlorophenyl)pyridazine is an inhibitor of delayed rectifier and transient outward potassium currents. The IC50 values for the blocking action of BCP on IKDR and IKA was calculated as 7.13 μM and 0.55 μM, respectively in acutely isolated rat hippocampal pyramidal neurons by using whole-cell patch-clamp technique. The parent compound, minaprine (Cat. No. M3157), has selective affinity for M1 muscarinic receptors and possesses memory-enhancing properties and also acts as an antidepressant.
| pricing |
|
| A78403 | 4-Aminopyridine 98% | | pricing |
|
| P6124 | 5-(4-Phenoxybutoxy)psoralen ≥98% (HPLC), solid | Selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity for Kv1.3 over Kv1.5, and 33-125-fold selectivity over other Kv1 family channels.
| pricing |
|
| H135 | 5-Hydroxydecanoic acid sodium salt solid, ≥97% (NMR) | Blocks post-ischemic actions of the K+ channel activator cromakalim.
| pricing |
|
| P3584 | L-α-Phosphatidyl-D-myo-inositol 4,5-diphosphate, dioctanoyl | | pricing |
|
| A6603 | Aa1 recombinant, expressed in Escherichia coli, >98% (HPLC), lyophilized powder | Blocks Shaker B channels expressed in Xenopus oocytes; blocks the fast (A-type) K+ current in cerebellum granular cells; the block is non-voltage dependent and does not affect kinetic parameters of the potassium currents. Originally isolated from Androctonus australis scorpion venom.
| pricing |
|
| A2647 | Adenosine 5′-(β,γ-imido)triphosphate tetralithium salt hydrate ~95% (HPLC), powder | A non-hydrolyzable ATP analog. AMP-PNP competitively inhibits ATP-dependent enzyme systems, such as glutamine synthetase. It inhibits a number of enzymes which require the hydrolysis of ATP such as DNA topoisomerase II, SV40 large T-antigen helicase and a number of kinases. Blocks ATP-sensitive calcium-dependent potassium channels.
| pricing |
|
| A5229 | Agitoxin-1 recombinant, expressed in E. coli, ≥98% (HPLC), lyophilized powder | Toxin found in the venom of the scorpion Leiurus quinquestriatus hebraeus. Potent blocker of the Shaker voltage-gated K+ channels as well as the mammalian homologues of Shaker
| pricing |
|
| A9219 | Agitoxin-2 from scorpion venom recombinant, expressed in Escherichia coli, ≥98% (SDS-PAGE), lyophilized powder | Potent Shaker K+ channel blocker . Useful as a probe for Kv channels.
| pricing |
|
| A5476 | Agitoxin-3 >98% (HPLC), recombinant, expressed in Escherichia coli, solid | Potent Shaker-like voltage-gated K+ channels and their mammalian homologs blocker.
| pricing |
|
| A7230 | Alinidine ≥98% (HPLC), solid | Alinidine is an HCN Channel blocker of neuronal Ih, related cardiac If channels and ATP-sensitive Kir channels. It is an analog of clonidine; bradycardic and antiarrhythmic agent (sinus tachyarrhythmias). Alinidine affects physiological markers in conscious dogs. Alinidine in four intravenous (i.v.) injections of 0.5, 0.5, 1, and 2 mg/kg, decreased sinus rate (< or = 43%) and ventricular rate (< or = 44%), but increased atrial rate (< or = 31%). It lengthened CSRT (< or = 71%) at the two highest doses and increased AERP (< or = 33%) and decreased WP (< or = 33%) at all doses. Alinidine did not modify mean blood pressure at any dose in either group. These results indicate that alinidine exhibits electrophysiologic effects in conscious dogs that reflect the marked antiarrhythmic potential of this agent, apart from its assumed antiischemic properties.
| pricing |
|
| A1289 | Apamin from bee venom, ≥95% (HPLC) | The only polypeptide neurotoxin that is known to pass the blood-brain barrier. Blocks ATP-type Ca+2-activated K+ channels.
| pricing |
|
| A9459 | Apamin synthetic, ≥97% (HPLC) | The only polypeptide neurotoxin that is known to pass the blood-brain barrier. Blocks ATP-type Ca+2-activated K+ channels.
| pricing |
|
| A7606 | Aprindine hydrochloride ≥98% (HPLC), solid | Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide and is effective in treatment of patients with ventricular premature depolarizations, ventricular tachycardia, and supraventricular arrhythmias. Aprindine inhibits the activation of bovine brain cyclic 3′:5′-nucleotide phosphodiesterase (EC 3.1.4.17) by calmodulin and inhibits calmodulin-stimulated Ca-ATPase (ATP phosphohydrolase EC 3.6.1.3) activity.
| pricing |
|
| B9554 | BDS-I ≥95%, lyophilized powder | Specifically blocks the rapidly inactivating Kv3.4 channel.
| pricing |
|
| B9679 | BDS-II ≥95%, lyophilized powder | Specifically blocks the rapidly inactivating Kv3.4 channel.
| pricing |
|
| B2186 | BL-1249 ≥98% (HPLC), solid | Putative activator of potassium TREK-1 channel
| pricing |
|
| B6934 | BeKm-1 lyophilized powder, >98% (HPLC), recombinant, expressed in Escherichia coli | Specifically blocks ERG1 K+ channels.
| pricing |
|
| C2499 | CP-339818 ≥98% (HPLC)  | CP-338818 blocks both Kv1.3 and Kv1.4. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain cells. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. CP-339818 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. CP-339818 is also valuable for the study of Kv1.4 function.
| pricing |
|
| C7802 | Charybdotoxin ≥90% (HPLC) | High (BK) or intermediate (IK1) conductance calcium-activated and voltage-gated (Kv1.3) channel blocker.
Potent and selective inhibitor of the Ca2+-activated K+ channel present in GH3 anterior pituitary cells and primary bovine aortic smooth muscle cells.
| pricing |
|
| C5856 | Charybdotoxin ≥98% (HPLC), recombinant, expressed in Escherichia coli, lyophilized powder | High (BK) or intermediate (IK1) conductance calcium-activated and voltage-gated (Kv1.3) channel blocker.
| pricing |
|
| C4397 | Chlorzoxazone | | pricing |
|
| C2615 | Chromanol 293B ≥98% (HPLC), solid | Blocker of the slow delayed rectifier K+ current via KCNQ1 channels
| pricing |
|
| C1618 | Cibenzoline succinate ≥97% (NMR), solid | Cibenzoline is a class IA antiarrhythmic drug. Cibenzoline (μM concentrations) blocks ATP-sensitive K channels in heart and pancreatic cells. Cibenzoline interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Cibenzoline also inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.
| pricing |
|
| C2365 | Clofilium tosylate >97%, solid | K+ channel blocker; cardiac depressant; anti-arrhythmic
| pricing |
|
| C6019 | Clotrimazole | Specific inhibitor of Ca2+-activated K+ channels. Antifungal azole. Antifungal mode of action: Inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.
| pricing |
|
| C1055 | Cromakalim | Causes vasodilation by activation of potassium channels.
| pricing |
|
| C5493 | CyPPA ≥98% (HPLC), solid | CyPPA is a positive modulator of small conductance Ca2+-activated K+ channels; selective for SK3 and SK2. CyPPA is a first subtype selective SK channel positive modulator with an EC50 of 5.6 μM and 14 μM, efficacy 90% and 71% for hSK3 and hSK2, respectively. CyPPA is a tool for distinguishing SK2 and SK3 from SK1 and IK; no other agents distinguish these channels.
| pricing |
|
| D6942 | DK-AH 269 ≥98% (HPLC), solid | DK-AH 269 (Cilobradine) is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.
| pricing |
|
| D7443 | DPO-1 needles, >97% (NMR) | DPO-1 is an inhibitor of human Kv1.5 potassium channel; representative blocker of a novel pharmacophore. The Kv1.5 potassium channel, which underlies the ultrarapid delayed rectifier current, IKur, is reported to be enriched in human atrium versus ventricle, and has been proposed as a target for novel atrial antiarrhythmic therapy. The administration of the IKur blocker (2-isopropyl-5-methyl-cyclohexyl) diphenylphosphine oxide (DPO-1) increases myocardial refractoriness in both atrium and ventricle of rat, but produces an atrial-selective increase in refractoriness in primates; appears to be 15-fold more selective for Kv1.5 vs Kv3.1 channels expressed in Xenopus oocytes. IC50 = 0.16-0.76 μM at 0.1 Hz pulsing frequency; Kd = 0.6 μM.
| pricing |
|
| D4688 | Dendrotoxin-I from Dendroaspis polylepis polylepis venom ≥98% (SDS-PAGE), lyophilized powder | Dendrotoxin-I blocks fast activation and slow inactivating potassium channels. It is the most abundant of the peptides in the venom of Dendroaspis polylepis polylepis.
| pricing |
|
| D4813 | Dendrotoxin-K ≥98% (HPLC), lyophilized powder | Dendrotoxin-K inhibits potassium channels that contain Kv1.1 protein only.1
| pricing |
|
| D3768 | Dequalinium chloride hydrate ≥95% (titration) | Selective blocker of apamin-sensitive K+ channels
| pricing |
|
| D9035 | Diazoxide | Selective ATP-sensitive K+ channel activator in both vascular smooth muscle and pancreatic β-cells; antihypertensive.
| pricing |
|
| M5060 | E-4031 ≥98% (HPLC), solid | E-4031 selectively blocks hERG K+ channels.
| pricing |
|
| E9904 | Ergtoxin from Centruroides noxius (Scorpion) recombinant, expressed in Escherichia coli, >98% (HPLC), lyophilized powder | A novel ERG1 (KV11.1) K+ channel blocker
| pricing |
|
| G2295 | Glimepiride ≥98% (HPLC), solid | Glimepiride is a potent blocker of cardiac KATP channels activated by pinacidil with an IC50 of 6.8 nM.
| pricing |
|
| G117 | Glipizide solid | ATP-dependent K+ channel blocker.
| pricing |
|
| G0639 | Glybenclamide ≥99% (HPLC) | Selectively blocks ATP-sensitive K+ channels; high affinity binding sites found in brain, pancreatic β cells, and cardiovascular system.
| pricing |
|
| H3163 | Heteropodatoxin-2 recombinant, expressed in Escherichia coli, >98% (HPLC), lyophilized powder | Blocks Ito1 in ventricular myocytes and KV4.2 expressed in Xenopus oocytes.
| pricing |
|
| H0287 | Hongotoxin-1 >98% (HPLC), lyophilized powder, recombinant, expressed in Escherichia coli | Blocks cloned and heterologously expressed Kv1.1, Kv1.2, Kv1.3 and Kv1.6 voltage-gated potassium channels.
| pricing |
|
| I2279 | IMID-4F hydrochloride solid, solubility: >9 mg/mL in H2O, soluble | Novel imidazoline-based K(ATP) channel blocker.
| pricing |
|
| I2141 | Iberiotoxin | Selective and reversible inhibitor of high-conductance calcium-activated potassium channel.
| pricing |
|
| I5904 | Iberiotoxin ≥98% (HPLC), recombinant, expressed in Escherichia coli | Selective and reversible inhibitor of high-conductance calcium-activated potassium channel.
| pricing |
|
| I9910 | Ibutilide hemifumarate salt ≥98% (HPLC) | Ibutilide hemifumarate salt is considered a new generation "pure" Class III antiarrhythmic agent. Ibutilide binds to and alters the activity of hERG potassium channels, delayed inward rectifier potassium (IKr) channels and L-type (dihydropyridine sensitive) calcium channels.
| pricing |
|
| I6783 | Isopimaric Acid ≥98% (GC), solid | Potent opener of large conductance calcium activated K+ (BK) channels.
| pricing |
|
| K3764 | Kaliotoxin-1 recombinant, expressed in Escherichia coli, ≥98% (HPLC), lyophilized powder | Blocker of Ca2+-activated and voltage-gated (KV1.1 and KV1.3) potassium channels
| pricing |
|
| L0540 | Levcromakalim ≥98%, solid | More active cromakalim enantiomer; potent KATP channel opener; relaxes vascular smooth muscle in vivo and in vitro.
| pricing |
|
| L1915 | Lq2 >98% (HPLC), recombinant, expressed in Escherichia coli, lyophilized powder | ROMK1 inward rectifier potassium channel blocker; also blocks single K(Ca) channels in planar lipid bilayer (rat muscle); Lq2 action is on the extracellular side of the pore.
| pricing |
|
| M8278 | Margatoxin ≥90% (HPLC) | Specific K(V)1.3 channel voltage-dependent K+ channel blocker
| pricing |
|
| M8437 | Margatoxin ≥99%, recombinant, expressed in Escherichia coli | Voltage-gated (Kv1.3) potassium channel blocker.
| pricing |
|
| M8036 | Mast Cell Degranulating Peptide | Toxic component of bee venom that selectively blocks some neuronal voltage-gated K+ channels; degranulates mast cells and releases histamine
| pricing |
|
| M7444 | Maurotoxin recombinant, expressed in Escherichia coli, ≥95% (HPLC), lyophilized powder | Maurotoxin is a 34 amino acid recombinant toxin, originally isolated from the venom of the scorpion Scorpio Maurus palmatus; a member of the α-KTx6.2 scorpion toxin family. It blocks voltage-gated potassium channels (KV1.1/KCNA1, KV1.2/KCNA2, and KV1.3/KCNA3) and inhibits apamin-sensitive small conductance calcium-activated channels (SK channels), particularly KCa3.1(IKca1, SK4).
| pricing |
|
| M7945 | Mephetyl tetrazole ≥98% (HPLC), oil | Mephetyl tetrazole is a potent and selective Kv1.5 potassium channel blocker. IC50 = 330 nM; shows selective atrial prolongation (40%) of effective refractory period (ERP), but no effect on ventricular ERP Kv1.5 channel is a molecular target for the treatment of atrial fibrillation.
| pricing |
|
| M3189 | Mepivacaine hydrochloride 98.0-102.0%, meets USP testing specifications | Local anesthetic. Reversibly blocks transient Na+ inward current, as well as the steady-state K+ outward current. Blocks tandem pore (TASK) and Kv1.5, potassium channels in model systems.
| pricing |
|
| M4145 | Minoxidil ≥99% (TLC) | Activates ATP-activated K+ channels.
| pricing |
|
| M7920 | Minoxidil sulfate salt | | pricing |
|
| A5513 | N-Acetylprocainamide hydrochloride ≥99% (HPLC), powder | Class III antiarrhythmic. Increases the duration of the action potential by decreasing the delayed outward potassium current, slightly decreasing the calcium current, and slightly depressing the inward rectifier potassium current. This is the active metabolite of procainamide that does not induce systemic lupus erythematosus.
| pricing |
|
| S6444 | N-Salicyloyltryptamine ≥98% (HPLC), solid | Activator of calcium-activated K+ channels; anticonvulsant and neuroprotectant.
| pricing |
|
| N170 | NS 1619 solid | Selective large conductance Ca2+-activated K+-channel activator.
| pricing |
|
| N0663 | NS1643 ≥98% (HPLC), solid | The new diphenylurea compound 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643) was tested in hERG channel. In Xenopus laevis oocytes, NS1643 increased both steady-state and tail current at all voltages tested. The EC50 value for hERG channel activation was 10.5 μM. The effect could be reverted by application of the specific hERG channel inhibitor 4′-[[1-[2-(6-methyl-2-pyridyl)ethyl]-4-piperidinyl]carbonyl]-methanesulfonanilide (E-4031) at 100 nM. Application of NS1643 also resulted in a prolonged postrepolarization refractory time. hERG channel activation by small molecules such as NS1643 increases the repolarization reserve and presents a new antiarrhythmic approach.
| pricing |
|
| N8161 | NS309 ≥98% (HPLC), solid | NS309 is a Ca2+-activated IK/SK potassium channel activator.
| pricing |
|
| N2538 | NS8593 hydrochloride ≥98% (HPLC), solid | The compound (R)-N-(benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphtylamine (NS8593) reversibly inhibited recombinant SK3-mediated currents (human and rat SK3) with potencies around 100 nM. NS8593 did not inhibit 125I-apamin binding. NS8593 decreased the calcium sensitivity by shifting the activation curve for Ca2+ to the right, only slightly affecting the maximal Ca2+-activated SK current. NS8593 inhibited all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+. NS8593 did not affect the calcium-activated potassium channels of intermediate and large conductance (hIK and hBK channels, respectively). NS8593-mediated inhibition was prevented in the presence of a high concentration of the positive modulator NS309.
| pricing |
|
| N3539 | Nicorandil ≥98% (HPLC) | Nicorandil is a hybrid ATP-sensitive K+ (KATP) channel opener and nicotinamide nitrate NO donor. Nicorandil selectively activates SUR2B- versus SUR2A-containing KATP channels. It enhances endothelial NO synthase expression and protects against ischemic ventricular arrhythmias. By activating potassium channels, and donating nitric oxide to activate the enzyme guanylate cyclase, Nicorandil causes activation of GMP leading to both arterial and venous vasodilatation. Nicorandil is selective for vascular potassium channels, but has no significant action on cardiac contractility and conduction.
| pricing |
|
| N0659 | Noxiustoxin ≥95% (HPLC), recombinant, expressed in Escherichia coli, lyophilized powder | Blocks voltage-gated potassium channels.
| pricing |
|
| O104 | Omeprazole solid | Binds covalently to proton pump; inhibits gastric secretion.
| pricing |
|
| P5624 | PD-118057 ≥98% (HPLC), solid | PD-118057 is an activator of ether-a-go-go-related (hERG) potassium channel. PD-118057 is a second identified hERG channel activator, a representative in the series of structural analogs; PD-118057 at 10 μM leads to a 111% current increase in rabbit ventricular wedge (in comparison RPR260243 leads to only a 15% increase at the same concentration);PD-118057, unlike RPR260243, does not have a major effect on gating or kinetic properties of this channel. PD-118057prevents and reverses QT interval prolongation; Compounds such as PD-118057 may offer new approach in the treatment of delayed repolarization conditions, which occur in inherited or acquired long QT syndrome and congestive heart failure
| pricing |
|
| P0248 | PNU-37883A ≥98% (HPLC), powder | Selective inhibitor of Kir6.1/SUR2B channels.
| pricing |
|
| P222 | Pandinotoxin-Kα >99%, powder | High affinity, selective A-type (rapidly inactivating) voltage-gated K+ channel blocker.
| pricing |
|
| P2928 | Paxilline powder, ≥98% (TLC) | Selective blocker of high-conductance Ca2+-activated (Maxi-K) potassium channels
| pricing |
|
| P3053 | Penitrem A ≥95% (TLC) | Tremorgenic fungal toxin; blocks high-conductance Ca2+-activated K+ channels.
| pricing |
|
| P3495 | Phrixotoxin-2 >98% (HPLC), lyophilized powder | Specific and reversible potassium Kv4.2 and Kv4.3 channel blocker. A natural peptide isolated from the tarantula phrixotrichus auratus venom.
| pricing |
|
| P154 | Pinacidil monohydrate solid | K+ channel activator; antihypertensive.
| pricing |
|
| P9872 | Psora-4 ≥98% (HPLC), solid | The lymphocyte potassium channel Kv1.3 is regarded as a new target for immunosuppression. Psora-4 is the most potent small-molecule Kv1.3 blocker known. It blocked Kv1.3 in a use-dependent manner, with a Hill coefficient of 2 and an EC50 value of 3 nM, by preferentially binding to the C-type inactivated state of the channel. It exhibited 17- to 70-fold selectivity for Kv1.3 over closely related Kv1-family channels (Kv1.1, Kv1.2, Kv1.4, and Kv1.7) with the exception of Kv1.5 (EC50, 7.7 nM) and showed no effect on human ether-a-go-go-related channel, Kv3.1, the calcium-activated K+ channels (IKCa1, SK1-SK3, and BKCa), or the neuronal NaV1.2 channel. In a test of in vivo toxicity in rats, Psora-4 did not display any signs of acute toxicity after five daily subcutaneous injections at 33 mg/kg body weight. Psora-4 selectively suppressed the proliferation of human and rat myelin-specific effector memory T cells with EC50 values of 25 and 60 nM, respectively, without persistently suppressing peripheral blood naive and central memory T cells. Because autoantigen-specific effector memory T cells contribute to the pathogenesis of T cell-mediated autoimmune diseases such as multiple sclerosis, Psora-4 and other Kv1.3 blockers may be useful as immunomodulators for the therapy of autoimmune disord.
| pricing |
|
| 145904 | Quinine 90% | Potassium channel blocker
| pricing |
|
| Q1250 | Quinine hemisulfate salt monohydrate synthetic, ≥90% (HPLC) | Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees.
| pricing |
|
| Q1750 | Quinine hydrobromide | Potassium channel blocker
| pricing |
|
| Q1125 | Quinine hydrochloride dihydrate | Potassium channel blocker
| pricing |
|
| R9028 | Repaglinide ≥98% (HPLC), solid | Potent short-acting insulin secretagogue that acts by closing ATP-sensitive potassium (KATP) channels in the plasma membrane of the pancreatic beta cell. It represents a new class of insulin secretagogues, structurally unrelated to sulphonylureas, which were developed for the treatment of type 2 diabetes.
| pricing |
|
| R3277 | Rutaecarpine >98% (HPLC) | Delayed rectifier K+ channel blocker. Inhibits platelet aggregation; vasoldilator.
| pricing |
|
| N135 | S(+)-Niguldipine hydrochloride solid | α1A-adrenoceptor antagonist; antihypertensive agent; L-type Ca2+ channel blocker; potassium agonist that activates Ca2+-activated maxi K-channels.
| pricing |
|
| S6193 | SG-209 solid, ≥98% (HPLC) | Potassium channel activator; analog of nicorandil; nitrate-free coronary vasodilator
| pricing |
|
| S2321 | Scyllatoxin recombinant, expressed in Escherichia coli, ≥95% (HPLC), lyophilized powder | Recombinant peptide of scyllatoxin, a 31 amino acid long toxin, originally isolated from the venom of the scorpion Leiurus quinquestriatus hebraeus; selective blocker of apamin-sensitive small-conductance Ca2+-activated K+ channels (SK channels) with highest affinity towards Kca2.2.
| pricing |
|
| S0323 | Sematilide monohydrochloride monohydrate ≥99% (HPLC), white solid | Sematilide monohydrochloride monohydrate is a class III antiarrhythmic; selective delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness; shows proarrhythmic effects and may lead to QT interval prolongation.
| pricing |
|
| S0944 | Slotoxin recombinant, expressed in Escherichia coli, >98% (HPLC), lyophilized powder | Blocks Maxi K+ (BKCa or slo, KCNMA1) channels; differentially blocks channels formed by the α1 subunit alone and channels formed by the α1 combined with auxiliary β subunits. In Xenopus oocytes expressing hSlo (α1 alone), Kd was calculated to be 1.5 nM and the block is complete and reversible. In the additional co-expression of either the β1 or β4 subunits, the block become irreversible or causes the channel to be almost insensitive to the toxin, respectively. Originally isolated from Centruroides noxius scorpion venom.
| pricing |
|
| LO2220 | Sodium/Potassium Channel Modulators Ligand Set ligand set for potassium/sodium channel modulators, exchangers, cotransporters, ionophores and ion pumps | | pricing |
|
| S1570 | Stromatoxin-1 recombinant, expressed in Escherichia coli, ≥98% (HPLC), lyophilized powder | Inhibitor of Kv2.1 potassium channels; toxin found in Stromatopelma calceata spider venom.
| pricing |
|
| T6700 | TRAM-34 ≥98% (HPLC), solid | TRAM-34 is a potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel.
| pricing |
|
| T3326 | Tamapin recombinant, expressed in Escherichia coli, ≥95% (HPLC), lyophilized powder | Member of the α-5.4 scorpion toxin family. Blocks KCa2 channels with selectivity for KCa2.2 versus KCa2.1 channels.
| pricing |
|
| T8316 | Tertiapin >95% | A potent inhibitor of the inward-rectifier K+ channels, blocked a G-protein-gated channel (GIRK1/4) and the ROMK1 channel with nanomolar affinities, however a closely related channel, IRK1, was insensitive to tertiapin. Thus, tertiapin is a tool for purifying functional channels as well as for screening pharmaceutical agents against these channels.
| pricing |
|
| T1567 | Tertiapin-Q trifluoroacetate salt ≥97% (HPLC) | Blocks the GIRK1/4 and ROMK1 members of the inward-rectifier K+ channel family.
| pricing |
|
| T7383 | Tetracaine ≥98% (TLC) | Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.
| pricing |
|
| T7508 | Tetracaine hydrochloride ≥99% | Blocks voltage-sensitive release of Ca2+ from sarcoplasmic reticulum.
| pricing |
|
| T2265 | Tetraethylammonium chloride ≥98% (titration) | Blocks K+ channels; blocks nicotinic acetylcholine neurotransmission by blocking the receptor-mediated K+ currents.
| pricing |
|
| T154 | Tityustoxin-Kα from Tityus serrulatus (Brazilian scorpion) venom lyophilized powder | Potent and selective voltage-gated non-inactivating (delayed-rectifier) K+ channel blocker.
| pricing |
|
| T2408 | Tolazamide | Stimulates pancreatic islet cells to secrete insulin; blocks ATP-sensitive K+ channels.
| pricing |
|
| U8881 | UCL 1684 ditrifluoroacetate hydrate | UCL 1684 ditrifluoroacetate hydrate is a potent non-peptide blocker of the apamin-sensitive Ca2+-activated K+ channel.
| pricing |
|
| U5883 | UCL-1848 trifluoroacetate salt ≥98% (HPLC), solid | Selective Ca2+-activated, SK potassium channel blocker
| pricing |
|
| U3885 | UK-78282 monohydrochloride ≥98% (HPLC) | UK-78282 blocks both Kv1.3 and Kv1.4. Kv1.3 and Kv1.4 are members of the Shaker family of voltage-gated potassium channels. Kv1.3 is expressed in brain and in effector memory T (Tem) cells, and Kv1.4 is expressed in brain. Both channels are involved in setting the membrane potential of neurons. In addition, Kv1.3 maintains the membrane potential for T memory cells and is up-regulated upon T cell activation, contributing to multiple immune processes and disorders. Blockers of Kv1.3 have long been sought for therapeutic benefit, and they are also valuable tools for studying the immune system. Selective blockers of Kv1.4 are desired, as there are few if any currently available. UK-78282 is valuable for immune system studies, where the absence of Kv1.4 makes it functionally selective for Kv1.3, and it has shown suppression of T cell activation. UK-78282 is also valuable for the study of Kv1.4 function.
| pricing |
|
| X2254 | XE-991 ≥98% (HPLC) | XE-991 is a KCNQ channel blocker; which is more potent than linopiridine (Cat. No. L-134).
| pricing |
|
| Z3777 | ZD7288 hydrate ≥98% (HPLC) | Selective blocker of cation channel Ih; If blocker and sino-atrial node function modulator, blocks hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels.
| pricing |
|
| Z0127 | Zatebradine hydrochloride ≥98% (HPLC), solid | HCN channel blocker: blocker of neuronal Ih, related cardiac If channels and ATP-sensitive Kir channels.
| pricing |
|
| D9667 | α-Dendrotoxin | Blocks slowly inactivating outward K+ current; blocks voltage-gated K+-channels in rat brain synaptosomes; increases acetylcholine release at neuromuscular junction.
| pricing |
|
| B9933 | β-Bungarotoxin, B Chain | Demonstrates K+ channel-blocking activity.
| pricing |
|
| D4438 | β-Dendrotoxin ≥98% (SDS-PAGE), lyophilized powder | | pricing |
|
| D0439 | δ-Dendrotoxin ≥98% (SDS-PAGE), lyophilized powder | Antagonizes the binding of p-aminoclonidine to α2-adrenoreceptors; blocks outward K+ current; blocks voltage-gated K+-channels in rat brain synaptosomes.
| pricing |
|
| D4563 | γ-Dendrotoxin ≥98% (SDS-PAGE), lyophilized powder | Blocks the noninactivating voltage-gated K+-channels.
| pricing |
|
Product # 