Gastrins

The main function of the peptide hormone gastrin is to stimulate the parietal cells of the stomach to produce hydrochoric acid. Produced in the stomach and duodenum, gastrin enters the circulation, and returns to the stomach to produce most of its effects. These effects include binding to cholecystokinin2 receptors to cause histamine release, causing the release of the digestive proenzyme pepsinogen, and stimulating growth and maturation of cells in the gastric mucosa. Gastrin is synthesized as a preprohormone, and then processed from the amino-terminus to several forms. We offer the human 17-amino acid peptide with and without sulfation of tyrosine12. Both forms are active. Unsulfated rat gastrin has a slightly different amino acid composition and is useful for animal research. We also offer a synthetic unsulfated human gastrin in which methionine15 is replaced with leucine for increased stability in aqueous solution.

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G9020 Gastrin I human ≥95% (HPLC) Produced in the stomach; stimulates gastric acid secretion
G9145 [Leu15]-Gastrin I human ≥95% (HPLC) Gastrin I analog with full biological activity and improved stability in aqueous solutions. Leu15 replaces Met15, that is readily oxidized resulting in loss of biological activity.
G1260 Gastrin II Sulfated ≥95% (HPLC) Gastrin II and Gastrin I are peptide hormones involved in gastrointestinal processes such as the stimulation of gastric (HCl) release.
G1276 Gastrin I rat ≥97% (HPLC) Gastrin plays a crucial role in the maintenance of architecture and function of oxyntic mucosa of stomach, which is involved in the secretion of acid. It also triggers the secretion of acid into the gastric lumen. Continuous increased plasma levels of gastrin or hypergastrinemia, may be involved in gastrointestinal carcinogenesis, especially if it is accompanied with inflammation. The release of this peptide is suppressed during distention, which is a result of omatostatin and intrinsic cholinergic pathways. In rats, this peptide maintains gastric mucosal integrity through the up-regulation of cyclooxygenase-2 which is, in part, mediated by heparin-binding epidermal growth factor-like growth factor (HB-EGF).