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Cholecystokinins

More recently this hormone has been recognized as a neurohormone, and is secreted by some neurons in the brain. It affects appetite, and may also have roles in anxiety and response to opiates. Cholecystokinin is found in several sizes resulting from proteolytic cleavage of a preprohormone. CCK-33 (33 amino acid residues) is the most abundant form in circulation, but CCK-8 retains full biological activity. Sulfation of the tyrosine seven residues from the carboxyl-terminus is required for biological activity of any length CCK. We offer de-sulfated CCK-8 for use as a control. CCK antagonists listed include Lorglumide and SR27897, specific to the CCKA receptor, LY225910, specific to the CCKB receptor, and proglumide that is more specific to CCKA than CCKB. Tetragastrin and pentagastrin are CCK-derived peptides that seem to promote anxiety

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B3144 Boc-Trp-Met-Phe amide ≥97% (TLC)  
SML0057 Camostat mesylate ≥98% (HPLC) Camostat is a synthetic, orally bioavailble serine protease inhibitor.
Camostat mesylate inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes. It also inhibits the activity of pancreatic stellate cells. Camostat mesylate regulates the cytokine expression and inflammation and is effective in the treatment of dibutyltin dichloride-induced rat pancreatic fibrosis.
C2901 Cholecystokinin (CCK) Fragment 26-33 Amide, Non-sulfated ≥95% (HPLC), powder Biologically inactive form of CCK-8; CCKB/gastrin receptor agonist that has no activity at the CCKA receptor.
T6515 Cholecystokinin Fragment 30-33 Amide ≥95% (HPLC) Cholecystokinin Fragment 30-33 Amide also referred to as CCK-4 or Trp-Met-Asp-Phe amide is a peptide fragment derived from peptide hormone cholecystokinin. CCK-4 is a panicogenic agent that induces panic attacks in humans. This property of the compound can be used in scientific research for testing the new anxiolytic drugs.
C9482 Cholecystokinin Precursor Fragment 107-115 Desulfated human >97% (HPLC) Desulfated fragment of the cholecystokinin precursor protein.
L109 Lorglumide sodium salt solid Potent and selective non-peptide cholecystokinin (CCKA) receptor antagonist; orally active.
L2545 LY225910 ≥98% (HPLC) Cholecystokinin is expressed in the gastrointestinal tract and the central nervous system. Cholecystokinin receptor type 2 (CCK2) is a GPCR that is highly expressed in brain and spinal cord. CCK2 is implicated in many brain processes, including mood, anxiety, and pain, through its modulation of GABA neurotransmission.

LY225910 is a potent, selective CCK2 antagonist. LY225910 blocks agonism of CCK2 by CCK-8S, the peptide agonist. LY225910 has been measured in multiple systems, including GABA efflux from cortical cultures, depolarization of spinal cord neurons (via potassium conductance), modulation of excitatory postsynaptic potentials (EPSPs) in nucleus accumbens slices, and enhancement of morphine analgesia.
B1636 Pentagastrin ≥95% (HPLC), powder CCKB agonist that stimulates gastric acid secretion; anxiogenic.
M006 Proglumide sodium salt solid CCK antagonist; selectively blocks CNS effects.
Non-peptide cholecystokinin receptor antagonist that has greater selectivity for the CCKA subtype; orally active.
SML0179 SR 27897 hydrate ≥98% (HPLC) SR 27897 has good brain accessibility and regulates the ileal motility through effects on peripheral nervous system.
SR 27897 is a potent, selective antagonist of the Cholecystokinin (CCK) receptor CCK1. SR-27897 blocks the elevation of leptin levels in the CNS following injection of CCK-8 peptide, and causes an increase in food intake in rats.
C2175 (Tyr[SO3H]27)Cholecystokinin fragment 26-33 Amide ≥97% (HPLC), powder Neurotransmitter; predominant form of CCK in CNS and gastrointestinal tract; may play a role in satiety.
SML0220 YM 022 ≥98% (HPLC) YM022 is a very potent, selective antagonist of the gastrin/cholecystokinin (CCK)-B receptor. The Ki value for CCKB is 68 pM vs 63 nM for CCKA. In rats, YM022 inhibits pentagastrin-induced gastric emptying with an ED50 or 7.8 nM/kg.