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E4625
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16,17-Epoxy-21-acetoxypregnenolone ≥98%
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D4875
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16-Dehydropregnenolone acetate ≥95%
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H5002
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17α-Hydroxypregnenolone
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P5902
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3α,12α-Dihydroxy-5β-pregnan-20-one 3,12-diacetate
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P2016
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3α,21-Dihydroxy-5α-pregnan-20-one ≥95%
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Positive allosteric modulator of GABAA receptors.
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P5052
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5α-Pregnan-3α-ol-11,20-dione powder, ≥98% (TLC)
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Synthetic steroid compound alphaxalone (AFX) - 5α-Pregnan-3α-ol-11,20-dione- is a neurosteroid that directly activates and potentiates GABAA receptor-activated membrane current (IGABA). It acts as a positive allosteric modulator of the GABAA receptor; anesthetic. The alpha subunit subtype of GABAA determines the efficacy, but not the potency, of AFX neuroactive steroid to potentiate IGABA.
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P8887
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5α-Pregnan-3α-ol-20-one solid
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Positive allosteric modulator of GABAA chloride channel.
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P8004
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5α-Pregnan-3β-ol-20-one 3β-acetate ≥98%
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SML0266
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AA 29504 ≥98% (HPLC)
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AA29504 is a GABAA positive modulator with a preference for extra-synaptic α4β3δ over α1β3γ2s synaptic receptors. AA29504 exhibits anxiolytic effects and reduces motor coordination in rat models.
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C0987
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CGP-13501 ≥98% (HPLC), solid
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Positive allosteric modulator of GABAB receptors.
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C0862
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CGP-7930 >98% (HPLC), solid
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Positive allosteric modulator of GABAB receptors.
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D5821
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DS2 ≥98% (HPLC)
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DS2 is a selective positive allosteric modulator of δ-GABAA receptors.
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D5297
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Dehydroisoandrosterone 3-sulfate sodium salt dihydrate ≥98%, powder
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Dehydroisoandrosterone 3-sulfate sodium salt dihydrate is a negative allosteric modulator of GABAA receptors.
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SML0295
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Dihydromyricetin ≥98% (HPLC)
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Dihydromyricetin (Ampelopsin) is a flavanonol with antioxidant and anti-cancer activity, found to have anti-alcohol intoxication effects. Its anti-alcohol effects appear to be by its actions as a positive modulator of GABA-A receptors at the benzodiazepine site.
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G007
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Guvacine hydrochloride ≥97% (NMR), solid
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GABA uptake inhibitor.
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N4034
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NCS-356 sodium salt hydrate solid, ≥98% (HPLC)
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γ-Hydroxybutyrate (GHB) receptor agonist.
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N4159
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NCS-382 hydrate solid, ≥98% (HPLC)
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γ-Hydroxybutyrate (GHB) receptor antagonist; anticonvulsant.
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N142
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NO-711 hydrochloride solid, ≥98% (HPLC)
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Potent and selective GABA uptake inhibitor that crosses the blood-brain barrier.
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211672
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Nipecotic acid 98%
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P162
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Pregnenolone sulfate sodium salt
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Neurosteroid that antagonizes the GABAA receptor chloride channel.
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SML0228
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Rc-Ome ≥98% (HPLC)
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Rc-OMe is a GABAA PAM that distinguishes α1β2γ2s from α1β2 receptors. The compound has very weak potentiating effects on α1β2, but potentiates GABA-elicited currents of α(123)β2γ2s receptors, all with low μM EC50s. Rc-OMe acts at a binding site that is distinct from BDZ, pentobarbital and loreclezole modulatory sites.
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SML0035
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Tiagabine hydrochloride ≥98% (HPLC)
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Tiagabine hydrochloride is an anticonvulsant and selective GABA reuptake inhibitor through inhibition of the synaptic GABA transporter GAT1.
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SML0275
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rac BHFF ≥98% (HPLC)
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rac BHFF is an orally active, potent and selective positive allosteric modulator of GABA-B. rac BHFF increases the potency and efficacy of GABA.
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