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Other Adrenergics

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H1377 4-Hydroxy-3-methoxyphenylglycol hemipiperazinium salt Cerebral norepinephrine metabolite.
H8759 4-Hydroxy-3-methoxyphenylglycol sulfate potassium salt ≥98% (HPLC), powder Norepinephrine metabolite that is often used as an index of adrenergic stimulation.
H2380 6-Hydroxy-DL-DOPA ≥98% (TLC), powder 6-Hydroxy-DL-DOPA is an inhibitor of APE1 (apurinic/apyrimidinic endonuclease) repair-function activity. APE1 is a nuclease crucial for DNA base excision repair pathway. 6-Hydroxy-DL-DOPA also blocks RAD52 (DNA repair protein) single-stranded DNA binding domain.
Precursor of the catecholaminergic neurotoxin, 6-hydroxydopamine; converted to 6-hydroxydopamine by L-aromatic amino acid decarboxylase.
H8523 6-Hydroxydopamine hydrobromide ≥90% (HPLC), solid Neurotoxin that destroys catecholaminergic terminals.
H116 6-Hydroxydopamine hydrobromide contains ascorbic acid as stabilizer, ≥98% (HPLC) Neurotoxin that destroys catecholaminergic terminals.
H4381 6-Hydroxydopamine hydrochloride ≥97% (titration), powder Neurotoxin that destroys catecholaminergic terminals.
D2384   DL-3,4-Dihydroxyphenylserine ≥98% (HPLC), powder Amino acid precursor of noradrenaline (NA); elevates brain NA concentrations.
H0131 DL-4-Hydroxy-3-methoxymandelic acid ≥98% (TLC), powder Epinephrine and norepineprine metabolite.
N7127 DL-Normetanephrine hydrochloride ≥98% Norepinephrine metabolite.
A3477 AH 11110 >98% (HPLC), solid α1B-adrenoceptor ligand
B8406 Bretylium tosylate >99% (TLC), powder Bretylium tosylate has a biphasic response, initially inducing norepinephrine release followed by sympathetic ganglionic blockade; class III antiarrhythmic agent; competitive inhibitor of acetylcholinesterase.
C3993 Carvedilol ≥98% (HPLC), solid Cavedilol is a non-selective β-adrenergic blocker with α1 blocking activity. Carvedilol is used specifically for the treatment of heart failure and high blood pressure. It has been shown to improve left ventricular ejection fraction and may reduce mortality.
D2069 Desvenlafaxine hydrochloride ≥98% (HPLC), powder Desvenlafaxine hydrochloride is a dual SERT/NET reuptake inhibitor. It is a major active metabolite of venlafaxine (#542); brain penetrant; Ki = 40 nM and 122 nM for hSERT and hNET, respectively (weak binding at the hDAT). Inhibition of [3H]5-HT or [3H]NE uptake for the hSERT or hNET produced IC50 values of 47 and 531 nM.
M1318 Milnacipran hydrochloride ≥98% (HPLC), solid Serotonin and norepinephrine reuptake inhibitor (SNRI)
C8417 N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride ≥98%, solid Adrenergic neurotoxin that induces acute and relatively selective degeneration of both central and peripheral noradrenergic nerve terminals.
SML0871   NeuroSensor 521 ≥98% (HPLC) NeuroSensor 521 is a fluorescent turn-on sensor designed for the selective visualization of norepinephrine over epinephrine in fixed and live cells and the fluorescence is not affected by fixation. NeuroSensor 521 binds to all primary amines, but binds catecholamines such as dopamine and norepinephrine more tightly than other biogenic amines such as glutamate and does not interact with secondary amines such as epinephrine. Because of the spectral properties of NeuroSensor 521, the unbound and bound states can be monitored using 440 and 488 nm excitation, respectively. In chromaffin cells NeuroSensor 521 stained the norepinephrine-containing cells preferentially over epinephrine-containing cells under identical conditions.
S9944 Sibutramine hydrochloride monohydrate ≥98% (HPLC), solid Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNRI). It is an antiobesity drug, which decreases calorie intake and increases energy expanditure. Sibutramine antagonizes MPTP-induced dopamine depletion in mouse brain.