Agonists

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E4250 (−)-Epinephrine Adrenoceptor agonist.
E4375 (−)-Epinephrine (+)-bitartrate salt solid Adrenergic receptor agonist.
I2760 (−)-Isoproterenol (+)-bitartrate salt powder β-Adrenoceptor agonist; increases cytosolic cAMP.
I6504 (−)-Isoproterenol hydrochloride β-adrenoceptor agonist; increases cytosolic cAMP.
A7257 (−)-Norepinephrine ≥98%, crystalline Adrenergic neurotransmitter
C125 (±)-CGP-12177A ≥98% (HPLC), solid β-adrenoceptor nonconventional partial agonist.
E4642 (±)-Epinephrine hydrochloride Adrenergic receptor agonist.
A0937 (±)-Norepinephrine (+)-bitartrate salt Adrenergic neurotransmitter
O0250 (±)-Octopamine hydrochloride ≥95%, solid α-adrenoceptor agonist; invertebrate neurotransmitter.
S0752 (±)-Synephrine ≥98% α-adrenoceptor agonist, vasoconstrictor.
P8155 (R)-(−)-Phenylephrine hydrochloride analytical standard α-Adrenergic agonist
P6126 (R)-(−)-Phenylephrine hydrochloride powder α1-adrenoceptor agonist.
A9512 L-(−)-Norepinephrine (+)-bitartrate salt monohydrate ≥99%, solid Adrenergic neurotransmitter, vasoconstrictor.
A5861 A-61603 hydrate ≥98% (HPLC) A-61603 is an α1A agonist. In radioligand binding assays, A-61603 was at least 35-fold more potent at α1A receptors than at α1b or α1d sites. In fibroblast cells transfected with α1a receptors, A-61603 more potently stimulated phosphoinositide hydrolysis than norepinephrine, and was antagonized by prazosin. A-61603 is less potent in cells transfected with α1b or α1d receptors. It is a potent agonist at α1A receptors in rat vas deferens (200- to 300-fold more potent than norepinephrine or phenylephrine, respectively) and in isolated canine prostate strips (130- to 165-fold more potent than norepinephrine or phenylephrine, respectively). In contrast, it is only 40-fold more potent than phenylephrine at α1B sites in rat spleen and 35-fold less potent at rat aortic, α1D sites. A-61603 induces a pressor response in conscious rats at doses 50- to 100-fold lower than phenylephrine.
SML1484 Allyphenyline oxalate ≥98% (HPLC) Allyphenyline is a potent α2C-adrenoceptor/serotonin 5-HT1A receptor agonist and α2A-adrenoceptor antagonist that exhibits anxiolytic effect and antidepressant activity. Allyphenyline attenuates opioid and alcohol withdrawal symptoms including hyperlocomotion and anxiety.
SML1667 Arformoterol tartrate ≥98% (HPLC) Arformoterol is the active isomer of formoterol. Arformoterol is a selective β2-adrenergic receptor agonist, a long-acting beta adrenergic agonist (LABA). Arformoterol is a bronchodilator used clinically as an anti-asthmatic and for treatment of chronic obstructive pulmonary disease (COPD).
B162 B-HT 920 dihydrochloride solid, ≥98% (HPLC) α2-adrenoceptor agonist; D2 dopamine receptor agonist.
B0185 BRL 35135A >96% (HPLC), solid β3-adrenoceptor agonist.
B169 BRL 37344 sodium salt hydrate solid BRL 37344 is a selective β3-adrenoceptor agonist. Studies support the hypothesis that there are peripheral β3 adrenergic receptors that can reduce food intake and that central β2 or β3 adrenergic receptors mediate the peripheral effects of the β3 agonist.
B8684 Bambuterol hydrochloride >98% (HPLC), powder β-adrenoceptor agonist; bronchodilator; anti-asthmatic; terbutaline prodrug
C5976 CL 316,243 hydrate ≥98% (HPLC), powder CL 316,243 is a β3 adrenoceptor agonist; anti-obesity agent.
C5423 Clenbuterol hydrochloride ≥95% β2-adrenoceptor agonist, bronchodilator.
SML0399 D,L-Metanephrine hydrochloride ≥98% (HPLC) Metanephrine is an endogenous metabolite of ephinephrine, formed by catechol-O-methyl transferase activity. It is best known as a biomarker for cancers, as levels of free metanephrine are used to diagnose pheochromocytoma. Metanephrine was previously thought to be biologically inactive, but it is a more potent agonist at Trace amine associated receptor TAAR1 than either epinephrine or norepinephrine. Trace amine associated receptors (TAARs) are recently discovered GPCRs that are activated by endogenous trace amines (tyramine, tryptamine, synephrine, octopamine, β-phenylethylamine), which are chemically similar to monoaminergic neurotransmitters (epinephrine, norepinephrine, dopamine). Trace amines and TAARs are expressed in brain and are implicated in modulation of monoaminergic neurotransmission.
SML0956   Dexmedetomidine hydrochloride ≥98% (HPLC) Dexmedetomidine hydrochloride is a highly potent and selective α2-adrenergic agonist with analgesic and sedative properties, the (+)-isomer of medetomidine. Dexmedetomidine hydrochloride is used clinically as an anesthetic agent to reduce anxiety and tension and promote relaxation and sedation without causing respiratory depression.
D0676 Dobutamine hydrochloride ≥98% β1-Adrenoceptor receptor agonist.
F1016 Fenoterol hydrobromide β2-adrenoceptor agonist; bronchodilator.
F9552 Formoterol fumarate dihydrate >98% (HPLC) β2-Adrenoreceptor agonist.
370625 Guanabenz Acetate - CAS 23256-50-0 - Calbiochem A cell-permeable α2-adrenoceptor agonist that lowers protein misfolding in stressed cells and acts as a proteostatis regulator.  
G110 Guanabenz acetate salt powder Centrally acting α2 adrenoceptor agonist; I2 imidazoline binding site ligand; antihypertensive.
G1043 Guanfacine hydrochloride ≥98% (HPLC) α-2 noradrenergic receptor agonist.
I3639 Isoetharine mesylate salt β-Adrenergic receptor agonist; bronchodilator.
I5627 Isoprenaline hydrochloride β-adrenoceptor agonist; increases cytosolic cAMP.
420355 Isoproterenol, Hydrochloride - CAS 51-30-9 - Calbiochem Phenethylamine derivative.  
324900 L-(–)-Epinephrine-(+)-bitartrate - CAS 51-42-3 - Calbiochem α,β-Adrenergic receptor agonist.  
489350 L-(–)-Norepinephrine-(+)-bitartrate - CAS 69815-49-2 - Calbiochem α,β-Adrenergic agonist.  
D9446 L-DOPS ≥98% (HPLC) L-DOPS is a norepinephrine precursor in vivo.
SML1362 L755507 ≥98% (HPLC) L755507 is a potent β3-adrenergic receptor partial agonist with an EC50 value of 0.43 nM for β3 receptors with over 440-fold selectivity for β3 compared to β1 and β2-adrenergic receptor binding. L755507 has been shown to enhance CRISPR-mediated homology-directed repair (HDR) efficiency in human induced pluripotent stem cells (iPSCs), increasing the efficiency of GFP insertion by 3-fold compared to control cells.
SML0138 Levalbuterol hydrochloride ≥98% (HPLC) Levalbuterol (levosalbutamol) is the more active isomer of albuterol. Levalbuterol is a β-adrenergic agonist; a bronchodilator used clinically to treat asthma and COPD..
Levalbuterol is (R)-albuterol that exhibits bronchodilator effect and is more effective than racemic albuterol for the treatment of exacerbation of asthma in pediatric populations.
M2398 Metaproterenol hemisulfate salt β2-adrenoceptor agonist
M4773 Metaraminol (+)-bitartrate salt α-adrenoceptor agonist.
M6524 Methoxamine hydrochloride α1-adrenoceptor agonist.
SML0460 Methylhexanamine hydrochloride ≥98% (HPLC) Methylhexanamine is a naturally substance isolated from Pelargonium graveolen. It is a component of geranium oil. Methylhexanamine is a sympathomimentic that increase levels of norepinephrine in the synaptic cleft.
M1559 Moxonidine hydrochloride ≥98% α2-adrenoceptor agonist and I1 imidazoline binding site agonist that, in many applications, demonstrates selectivity for the high-affinity I1 imidazoline binding site over the α2-adrenoceptor; antihypertensive. Its analgesic effects appear to be due to its agonist activity at spinal α2C-adrenoceptors.
N5504 Naphazoline hydrochloride α-adrenoceptor agonist; imidazoline receptor agonist; vasoconstrictor.
O2378 Oxymetazoline hydrochloride ≥99%, solid Oxymetazoline hydrochloride is a partial α2A-adrenoceptor agonist; agonist at 5-HT1A, 5-HT1B, and 5-HT1D serotonin receptors. It is a mixed agonist-antagonist at 5-HT1C serotonin receptors.
PZ0263 PF-3774076 ≥98% (HPLC) PF-3774076 is a CNS penetrant, potent, selective, partial agonist at the human α1A adrenoceptor. PF-3774076 is selective over α1B and α1D adrenoceptors.
P9180 Procaterol hydrochloride β2-adrenoceptor agonist; bronchodilator.
D7815 R(−)-Denopamine ≥98% (HPLC), powder β1-adrenoceptor agonist.
R0758 Ritodrine hydrochloride β2-adrenoceptor agonist; relaxes uterine muscle contraction.
SML1070 SR-58611A ≥98% (HPLC) SR58611A is a potent, specific b3 adrenergic receptor agonist. The EC50 for reduction of β3-mediated spontaneous motility in rat distal colon sections is 3.5 nM. Minimal anti-depressant efficacious doses for SR58611A are 0.1-0.3 mpk in rodent models.
S8260 Salbutamol β2-adrenoceptor agonist
Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).1 Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.2
S5013 Salbutamol hemisulfate salt ≥98% β2-Adrenergic receptor agonist.
Salbutamol is a β2 adrenoceptor agonist with short acting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles and inhibits bronchoconstriction induced by adenosine-5′ -monophosphate (AMP).1 Salbutamol is particularly effective in treatment of asthma as it provides immediate relief.2
S5068 Salmeterol xinafoate ≥98% (HPLC), solid β2-adrenoceptor agonist.
Salmeterol xinafoate is a β2 adrenoceptor agonist with longer lasting bronchodilation and anti-inflammatory effects. It relaxes the airway smooth muscles, stabilizes mast cells and regulates the release of histamine. Salmetrol is particularly effective in treatment of mild asthma, chronic obstructive pulmonary disorder.5,6
T2528 Terbutaline hemisulfate salt Terbutaline is a β-adrenoceptor agonist and is known to function as a bronchodilator. Studies have reported that terbutaline is potent inhibitor of premature labor6.
T4264 Tetrahydrozoline hydrochloride ≥98% α-adrenoceptor agonist; imidazoline binding site ligand; vasoconstrictor.
T6950 Tizanidine hydrochloride ≥98% (HPLC), powder α2-adrenoceptor agonist.
Tizanidine hydrochloride is known to function as a skeletal muscle relaxant that acts centrally. Furthermore, this relaxant functions at spinal and supraspinal levels to block excitatory interneurons. This drug is used for the symptomatic relief of spasticity and painful muscle spasms.
U104 UK 14,304 UK 14,304 is an α2-adrenoceptor agonist.
X1251 Xylazine hydrochloride ≥99% α2-Adrenergic receptor agonist, sedative, muscle relaxant.
X1126 Xylazine ≥99% α2-adrenoceptor agonist, sedative, muscle relaxant.
X6000 Xylometazoline hydrochloride α-adrenoceptor agonist; imidazoline binding site ligand.
Z4902 ZD 7114 hydrochloride ≥98% (HPLC) ZD 7114 is a selective β3 adrenergic receptor agonist. β3 adrenoceptors are expressed in adipose tissue and smooth muscle.
Z4402 Zinterol hydrochloride ≥98% (HPLC) Zinterol Hydrochloride is a β2 adrenergic receptor selective agonist.
SML0675   α-Methylnorepinephrine ≥95% (HPLC) α-Methylnorepinephrine is a sympathomimetic amine and vasoconstrictor. α-Methylnorepinephrine is used clinically in dentistry in local anesthetic solutions.
A0779 p-Aminoclonidine hydrochloride solid α2-adrenoceptor agonist.