AMPA/Kainate Agonists

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A9111 (±)-AMPA hydrobromide ≥98% (HPLC) (±)-AMPA is a potent excitatory amino acid that interacts selectively with central AMPA/kainate receptors.
A6816 (±)-AMPA solid Potent excitatory amino acid that interacts selectively with central AMPA/kainate receptors.
A0326 (S)-AMPA ≥98% Active enantiomer of (RS)-AMPA zwitterion. Potent agonist at the AMPA subclass of ionotropic glutamate receptors.
A5352 L-(+)-2-Amino-6-phosphonohexanoic acid ≥98% (HPLC), solid L-(+)-2-Amino-6-phosphonohexanoic acid (L-AP6) is an excitatory glutamate analogue that is able to depolarize L-quisqualic acid (QUIS)-sensitized CA1 rat hippocampal neurons.
A263 ATPA solid Selective kainate receptor agonist.
SML1191 CX516 ≥98% (HPLC) CX516 is a positive allosteric modulator at AMPA receptor that inhibits the deactivation of AMPA receptors. CX-516 is a nootropic and ampakine agent.
D6152 Domoic acid ≥90% (HPLC) Potent agonist at receptors for excitatory amino acids glutamate and kainate; has highest affinity for AMPA/kainate receptor of any kainate agonist; causes excessive excitation of neurons leading to depletion of energy stores.
G7798   GYKI-53655 hydrate >99.0% (HPLC) GYKI-53655 is an AMPA antagonist and noncompetitive negative allosteric modulator.
K0250 Kainic acid monohydrate ≥99% (TLC) Kainic acid monohydrate is an agonist at the kainate class of ionotropic glutamate receptors, which induces seizures and neurodegeneration in vivo and is used to induce experimental epilepsy in rodents and study the mechanisms of excitation-induced neuronal apoptosis.
PZ0215   PF-04701475 ≥98% (HPLC) PF-04701475 is a potent and selective α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) positive allosteric potentiator.
PZ0216   PF-04725379 ≥98% (HPLC) PF-04725379 is a potent and selective α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) positive allosteric potentiator.
PZ0250 PF-04859989 hydrochloride ≥98% (HPLC) PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates.
PZ0211   PF-4778574 ≥98% (HPLC) PF-4778574 is a potent AMPA receptor positive allosteric modulator (PAM) that has been shown to enhance cognition in animal models.
Q2128 Quisqualic acid powder Active enantiomer of quisqualic acid; excitatory amino acid at glutamate receptors.
U4135 UBP302 ≥98% (HPLC) UBP302 is a selective GluR5 antagonist. UBP302 is the active enantiomer of UB296 and is one of the most potent GluR5 antagonists available for research use.
V5390 VU0029251 ≥98% (HPLC), powder VU0029251 is the first example of a partial mGluR5 partial antagonist that is not based on the MPEP scaffold. The compound displays a maximum inhibition of 50% activity, and cannot completely displace [3H] MPEP, suggesting that competition for MPEP is also allosteric, involving a unique site.
SML1836 β-ODAP ≥98% (HPLC) New β-ODAP is a potent inhibitor of HIF-prolyl hydroxylase-2 (PHD-2) that induces HIF dependent HRE (hypoxia response element) in normoxic conditions. β-ODAP is an analog of glutamic acid present in Lathyrus sativus (grass pea) that activates AMPA receptors. β-ODAP causes neurolathyrism upon prolonged consumption of L. sativus seeds.