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M4796
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(±)-α-Methyl-(4-carboxyphenyl)glycine
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Competitive antagonist at Group 1 (mGluR1 and mGluR5) and Group 2 (mGluR2 and mGluR3) metabotropic glutamate receptors.
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M5046
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(±)-α-Methyl-(4-sulfonophenyl)glycine
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Antagonist at Group III metabotropic glutamate receptors.
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M196
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(+)-α-Methyl-4-carboxyphenylglycine solid
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Competitive metabotropic glutamate receptor antagonist.
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M5560
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(S)-2-Amino-2-methyl-4-phosphonobutyric acid hydrochloride synthetic, solid
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Selective mGluR4,6,7 metabotropic glutamate receptor antagonist.
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M5435
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6-Methyl-2-(phenylethynyl)pyridine hydrochloride ≥98% (HPLC)
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Highly selective, non-competitive mGluR5 metabotropic glutamate receptor antagonist.
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A4910
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DL-2-Amino-3-phosphonopropionic acid
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Potent metabotropic glutamate receptor antagonist.
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A154
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L-(+)-2-Amino-3-phosphonopropionic acid
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Potent antagonist at metabotropic glutamic acid receptors.
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A254
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AIDA solid
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Selective mGluR1 metabotropic glutamate receptor antagonist.
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C9749
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CBiPES hydrochloride ≥98% (HPLC)
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CBiPES is a positive allosteric modulator of the mGlu2 receptor. CBiPES attenuates stress-induced hyperthermia and blocks the hyperlocomotor effects of PCP in murine models. In rat brain, CBiPES attenuates ketamine-induced increase in extracellular histamine concentration. This compound is a sulfonamide, different chemical class from other mGlu2R agonists in the Sigma catalog.
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SML0258
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CPPG ≥98% (HPLC)
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CPPG is a potent group II/III metabotropic glutamate receptor antagonist, with approximately 20-fold selectivity for mGlu group III over group II (IC50 values of 2.2 and 46.2 nM respectively).
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C2247
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CPPHA ≥98% (HPLC)
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CPPHA is a selective positive allosteric modulator of mGluR5 receptor. It has no agonist activity alone, but reduces threshold response and shifts dose-response curves to glutamate, quisqualate, and DHPG by 4- to 7-fold to the left in recombinant CHO cells expressing human or rat mGluR5.
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M3074
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MMPIP ≥98% (HPLC)
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MMPIP is a potent, selective, allosteric antagonist of metabotropic glutamate receptor 7 (mGluR7). It also displays intrinsic activity and acts as an inverse agonist.
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M4699
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MTEP hydrochloride ≥98% (HPLC)
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MTEP is a potent and highly selective antagonist for mGluR5.
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S9186
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SIB 1757 ≥99% (HPLC), crystalline
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Highly selective mGluR5 metabotropic glutamate receptor antagonist.
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S9311
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SIB 1893 >99%, solid
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Selective and noncompetitive mGlu5 metabotropic glutamate receptor antagonist.
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Y1271
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YM-202074 sesquifumarate salt hydrate ≥98% (HPLC)
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YM-202074 is a potent and selective allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist. It bound an allosteric site of rat mGluR1 with a Ki value of 4.8 nM. It also inhibited the mGluR1-mediated inositol phosphates production in rat cerebellar granule cells with an IC50 value of 8.6 nM, while showing selectivity over mGluR(2-7).
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SML0574
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YM-298198 is an orally active, noncompetitive mGlu1 receptor antagonist. The compound inhibits glutamate-induced inositol phosphate production in NIH3T3 cells (IC50 = 16 nM). YM-298198 displays analgesic and antinociceptive properties in vivo.
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