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D101 (±)-DOI hydrochloride ≥98% (HPLC), solid (±)-DOI hydrochloride is a potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier, increases dopamine turnover and the treatment with DOI counteracted the expression of the nicotine-induced locomotor and neurochemical sensitization, but had no effect on nicotine-induced behavioral disinhibition. The responses to DOI provide evidence that of these receptors are abundant in the cortex, and show relatively lower levels in hippocampus and cerebellum.
    • N3288 (+)-Norfenfluramine hydrochloride ≥98% (HPLC), powder (+)-Norfenfluramine is the major hepatic metabolite of (+)-fenfluramine and is primarily responsible for the anorexic effect, as well as side effects; (+)-norfenfluramine causes vasoconstriction and a blood pressure increase in rats with normal blood; acts primarily on the cytoplasmic pool of serotonin; more potent than fenfluramine at inducing dopamine release.
    • D153 (R)(−)-DOI hydrochloride ≥98% (HPLC), solid Potent and selective 5-HT2 serotonin receptor agonist that crosses the blood-brain barrier; more potent enantiomer of ±-DOI hydrochloride.
    • H140 (R)-(+)-8-Hydroxy-DPAT hydrobromide ≥98% (HPLC), solid (R)-(+)-8-Hydroxy-DPAT is a full 5-HT1A serotonin receptor agonist; active enantiomer of (±)-8-hydroxy-DPAT.
    • C144 1-(3-Chlorophenyl)biguanide hydrochloride solid Very potent 5-HT3 serotonin receptor agonist.
    • 125180 1-(3-Chlorophenyl)piperazine hydrochloride 99% 5-HT2c serotonin receptor agonist; metabolite of trazodone.
    • 164216 1-Phenylbiguanide 98%  
    • C117 5-Carboxamidotryptamine maleate salt powder, ≥98% (HPLC) Agonist at 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5 and 5-HT7 serotonin receptors.
    • M2381 5-Methoxy-N,N-dimethyltryptamine Hallucinogen; non-selective serotonin receptor agonist.
    • M3196 5-MEO-DIPT hydrochloride hydrate 5-MeO-DIPT is a tryptamine derivative. In animal behavioral studies, 5-MeO-DIPT has been shown to produce behavioral effects that are substantially similar to those of LSD, both schedule I hallucinogens.
    • B4063 BIMU8 hydrate ≥98% (HPLC) BIMU8 hydrate is a potent 5-HT4 serotonin receptor agonist. Serotonin (5-HT) is a major neurotransmitter that acts through a family of GPCRs and one ion channel. 5-HT4 receptor is GPCR expressed in many tissues, including brain, and modulates dopamine secretion, learning, and memory. BIMU8 is a full agonist at 5-HT4, but it binds differently than the endogenous ligand, 5-HT, shown through site-directed mutagenesis studies. It depolarizes neurons and was used to localize 5-HT4 to somatic but not dendritic regions of CA1 pyramidal neurons.
    • B173 BRL 54443 maleate salt solid Potent 5-HT1E/1F serotonin receptor agonist.
    • B175 BW 723C86 solid, ≥98% (HPLC) 5-HT2B serotonin receptor agonist.
    • B7148 Buspirone hydrochloride 5-HT1A serotonin receptor agonist; anxiolytic.
    • C106 CGS-12066 maleate salt solid 5-HT1B serotonin receptor agonist.
    • PZ0121 CP-135807 ≥98% (HPLC) CP-135807 is a selective 5-HT1D agonist.
    • PZ0102 CP-93129 dihydrochloride hydrate ≥98% (HPLC) CP-93129 is a potent and selective 5-HT1B agonist.
    • SML0588 CP-94,253 dihydrochloride ≥98% (HPLC) New CP-94,253 is a potent and selective serotonin 5-HT1B receptor agonist with approximately 25x and 40x selectivity over the closely related 5-HT1D and 5-HT1A receptors. Ki values are 89, 2, 860, 49 and 1,600 nM for 5-HT1A, 5-HT1B, 5-HT1C, 5-HT1D and 5-HT2 receptors respectively. CP-94,253 was found to be anxiolytic in animal models; dose-dependently enhanced reinforcing effects of cocaine (self-administration);and reduced food intake.
    • SML0139 EMD386088 ≥98% (HPLC) EMD-386088 is a potent serotonin 5-HT6-specific agonist. The IC50 for competition of LSD from 5-HT6 expressed in HEK cells is 7.4 nM, and the EC50 for stimulating cAMP production is 1 nM. EMD-386088 is inactive against other HT receptors except 5-HT3 (IC50 = 34 nM).
    • PZ0011 Eletriptan hydrobromide ≥98% (HPLC) Eletriptan hydrobromide is a serotonin 5-HT1B/1D receptor agonist; second generation anti-migraine drug.
    • L3169 LP 12 hydrochloride hydrate ≥98% (HPLC), solid LP 12 dihydrochloride is a 5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.13, 224, 60.9 and 1464 nM, respectively. It also displays selectivity over D2, 1723; over 5-HT1A, 468; over 5-HT2A, 11261; and high potency. Sigma has added LP 44 (L9793) which shows significantly lower D2 selectivity (7.3 nM/0.22 nM for 33-fold), lower selectivity over 5-HT1A, 240; and over 5-HT2A, 1482. LP 12 and LP 44 seem to share a common intermediate.
    • L9793 LP44 ≥98% (HPLC), solid LP44 is a high affinity 5-HT7 receptor agonist. Ki = 0.22 nM. LP44 displays selectivity over 5-HT1A and 5-HT2A receptors (200- and >1000-fold, respectively). LP44 induces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).
    • S009 LY-165,163 solid Selective 5-HT1A serotonin receptor agonist and 5-HT1D serotonin receptor antagonist.
    • SML0010 LY-334370 hydrochloride hydrate ≥98% (HPLC), powder LY-334370 hydrochloride is a selective 5-HT1F receptor agonist.
    • SML0556   LY344864 hydrochloride ≥98% (HPLC) New LY344864 hydrochloride is a potent and selective 5-HT1F receptor agonist. It has an EC50 of 3 nM, and displays > 80-fold selectivity over other 5-HT receptors
    • L7007 Lysergic acid diethylamide Potent hallucinogen; non-selective serotonin receptor agonist.
    • M7319 ML 10302 ≥98%, solid Potent, selective 5-HT4 serotonin receptor agonist
    • M2946 Mosapride citrate salt dihydrate 5-HT4 receptor agonist and 5-HT3 receptor antagonist
    • D132 N,N-Dipropyl-5-carboxamidotryptamine maleate salt solid Potent and selective 5-HT1A serotonin receptor agonist.
    • Q107 N-Methylquipazine dimaleate salt solid Tertiary amine analog of quipazine that is an agonist at 5-HT3 serotonin receptors with an affinity similar to that of quipazine, but which lacks affinity for central 5-HT1B serotonin receptors.
    • N1415 Naratriptan hydrochloride ≥98% (HPLC) Naratriptan hydrochloride is a serotonin 5-HT1B/1D receptor agonist.
    • M6628 O-Methylserotonin hydrochloride crystalline Nonselective serotonin receptor agonist that lacks affinity for the 5-HT3 receptor.
    • P2279 Psilocin Hallucinogen originally isolated from the mushroom, Psilocybe mexicana, non-selective serotonin receptor agonist.
    • Q1004 Quipazine maleate salt Non-selective serotonin receptor agonist.
    • U109 R(+)-UH-301 hydrochloride solid Potent and selective 5-HT1A serotonin receptor agonist.
    • SML0247 Rizatriptan benzoate salt ≥98% (HPLC) Rizatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine.
    • R0408 Ro 60-0175 ≥99% (HPLC) Ro 60-0175 was originally reported to be a potent, selective 5-HT2C receptor agonist (with pKi values of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). That assignment has been questioned, however, supported by evidence from coadministration of Ro 60-0175 and SB 242084, a selective 5-HT2C antagonist.1
    • H141 S(−)-8-Hydroxy-DPAT hydrobromide solid Partial 5-HT1A serotonin receptor agonist.
    • D154 S(+)-DOI hydrochloride solid Less potent enantiomer of (±)-DOI.
    • S5321 S15535 ≥98% (HPLC), solid Potent, orally active, partial 5-HT1A receptor agonist
    • PZ0146 SC-53116 hydrochloride hydrate ≥98% (HPLC) SC-53116 is a 5-HT4 receptor partial agonist. SC-53116 has been shown to ameliorate scopolamine-induced impairment in learning in rats at a does of 10 μg/rat i.c.v and increase population spike amplitude in the CA1 and CA3 fields of the hippocampus at the same concentration.
    • S1688 SR 57227A solid Potent and selective 5-HT3 serotonin receptor agonist.
    • SML0260 ST1936 ≥98% (HPLC) ST1936 is a high affinity 5-HT6-specific agonist (Ki = 13 nM). The IC50 for competition of LSD from 5-HT6 expressed in HEK cells is 40 nM, and the EC50 for stimulating cAMP production is 16 nM.
    • H7752 Serotonin creatinine sulfate monohydrate powder Neurotransmitter.
    • H9523 Serotonin hydrochloride powder Neurotransmitter.
    • H4511 Serotonin hydrogen maleate powder Neurotransmitter.
    • H7877 Serotonin hydrogenoxalate powder Neurotransmitter.
    • S6319 Sertraline hydrochloride ≥98% (HPLC) Selective serotonin reuptake inhibitor, antidepressant.
    • S1198 Sumatriptan succinate ≥98% (HPLC), solid Sumatriptan succinate is a 5-HT1 serotonin receptor agonist.
    • T6704 Tandospirone ≥98% (HPLC) Tandospirone is a partial agonist at 5HT1A receptors. It significantly reduces haloperidol-induced bradykinesia in a dose-dependent manner. The potency of tandospirone is equal to that of buspirone and approximate half that of diazepam. The potency of tandospirone as a dopamine antagonistic is less than 1/4 that of buspirone.
    • V1889 VER-3323 hemifumarate salt >98% (HPLC), solid 5-HT2C/ 5-HT2B serotonin receptor agonist.
    • X4879 Xaliproden hydrochloride ≥97% (HPLC), solid 5-HT1A serotonin receptor agonist; neuroprotectant
    • SML0248 Zolmitriptan ≥98% (HPLC) Zolmitriptan is a selective serotonin receptor agonist of the 5HT1B and 5HT1D subtypes, both centrally and peripherally. It has been used clinically for the acute treatment of migraine attacks with or without aura and cluster headaches.
    • M110 α-Methylserotonin maleate salt ≥98% (HPLC), solid 5-HT2 serotonin receptor agonist.
    • U6883 cis-Urocanic acid ≥98% (HPLC), solid (fluffy) cis-Urocanic acid, a 5-HT agonist, is a product of uv isomerization of trans-urocanic acid in skin, which leads to immunosuppression via activation of 5-HT2A receptor.