Angiotensins

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SML1373 Angiotensin A trifluoroacetate salt ≥98% (HPLC) Angiotensin A (Ang A) is an endogenous vasoconstrictor octapeptide. It is a derivative of angiotensin II (Ang II) that differs from Ang II in having alanine instead of aspartic acid as the first amino acid. Angiotensin A has similar affinity as Angiotensin II for AT1 and AT2 receptors with Ki values of 1.6 and 2.3 nM at AT1 and AT2 receptors.
A9202 Angiotensin Fragment 1-7 acetate salt hydrate ≥90% (HPLC), powder Angiotensin I metabolite that is an AT2 receptor agonist.
A9650 Angiotensin I human acetate salt hydrate ≥90% (HPLC) Angiotensin I is a putative neurotransmitter. It is the precursor of angiotensin II and of angiotensin fragment 1-7, which are the hormones involved in regulation of fluid volume and the release of aldosterone.
A6402 [Asn1, Val5]-Angiotensin II ≥97% (HPLC) Synthetic angiotensin agonist that is involved in the regulation of blood pressure, water consumption, and hydromineral balance in fish.
A9900 [Sar1, Thr8]-Angiotensin II acetate salt hydrate ≥97% (HPLC) Potent, long-acting antagonist of angiotensin II.
A2275 [Sar1, Val5, Ala8]-Angiotensin II acetate salt hydrate ≥97% (HPLC), powder Competitive angiotensin II antagonist; inhibits pressor effects of angiotensin II in rats and lowers blood pressure in humans.
A2900 [Val5]-Angiotensin II acetate salt hydrate ≥95% (HPLC), powder Angiotensin II analog that is an agonist AT1 angiotensin receptors.
A9525 Angiotensin II human ≥93% (HPLC), powder Angiotensin II (angII) is an octapeptide hormone which affects the activities of heart, kidney, vasculature and brain. AngII in blood is produced from angiotensinogen via renin and angiotensin converting enzyme (ACE). It works via binding to specific receptors present on cell membranes. AngII is a component of the renin-angiotensin system. It is associated with vasoconstriction, induction of vascular smooth muscle cell growth, stimulation of protooncogene expression, modulation of myocardial hypertrophy, renal failure and fibrosis.
10385 Angiotensin III trifluoroacetate salt hydrate ≥98.0% (HPCE) Angiotensin III is an AT1 and AT2 agonist, with higher sensitivity for the AT2 receptor. Ang III has been shown to be a main effector peptide in RAS-controlled vasopresin release and a stimulator for aldosterone release.
A6277 [Val4]-Angiotensin III acetate salt hydrate ≥97% (HPLC)  
A0230 Angiotensin IV trifluoroacetate salt ≥95% (HPLC), powder AT4 angiotensin receptor agonist. The AT4 receptor appears to be important in synaptic plasticity and thus in learning and memory.
A6469 Apelin-13 trifluoroacetate salt ≥95% Synthetic endogenous peptide agonist for the human APJ receptor, a putative receptor protein related to the angiotensin receptor (AT1). This peptide exerted an acidification-rate-promoting activity in CHO cells expressing the APJ receptor with a median effective concentration (EC50) value of 0.37 nM. Blocks HIV-1 and HIV-2 entry into cells expressing the APJ receptor.
SML0432 Azilsartan ≥98% (HPLC) Azilsartan is a highly potent and slowly dissociating Angiotensin II type 1 (AT1) receptor blocker (ARB) with an IC50 of 2.6 nM. It is the active form of Azilsartan medoxomil, used for treatment of hypertension. Azilsartan may also have potentially beneficial effects on metabolic syndrome including insulin sensitizing activity that may involve more than just blockade of AT(1) receptors.
C160 CGP-42112A ≥95%, synthetic, solid Potent AT2 angiotensin II receptor agonist.
SML1455 DAA-I acetate salt ≥98% (HPLC) DAA-I (des-aspartate-angiotensin-I) is an agonist on the angiotensin AT1 receptor and releases prostaglandins which mediate its actions. DAA-I administer at doses lesser than Km of metabolizing enzymes antagonize the deleterious actions of angiotensin II. DAA-I appear function in vivo as a physiological antagonist to angiotensin II.
E2535 Eprosartan mesylate ≥98% (HPLC) Angiotensin II type 1 (AT1) receptor antagonist; anti-hypertensive.
F1308 Fosinopril sodium ≥98% (HPLC), powder Fosinopril is an angiotensin converting enzyme (ACE) inhibitor. Fosinopril is also known to inhibit the activity of the peptide transporter PEPT2.
I2286 Irbesartan ≥98% (HPLC), powder Irbesartan is an angiotensin II type 1 (AT1) receptor antagonist with anti-hypertensive activity.
L1415 L-162,313 ≥95%, solid Non-peptide AT1 receptor agonist.
SML0919 ML221 ≥98% (HPLC) ML221 is an antagonist of the apelin receptor (also known as APJ). ML221 blocks Apelin-13 mediated receptor activation (recruitment of β-arrestin) with an IC50 of 1.75 μM.
M0821 Moexipril hydrochloride powder, ≥98% (HPLC) Moexipril is an ACE-Inhibitor; Antihypertensive; Unlike other ACE inhibitors, prolongs QT interval leading to torsades de pointes and cardiad arrhythmia;
N0415 Novokinin trifluoroacetate salt ≥95% (HPLC) Novokinin trifluoroacetate is a angiotensin II receptor 2 (AT2) agonist.
SML1394 Olmesartan ≥98% (HPLC) Olmesartan is an Angiotensin II Type I receptor blocker. Olmesartan is the active form of the antihypertensive drug olmesartan medoxomil.
P5749 S-(+)-PD 123177 trifluoroacetate salt hydrate ≥98% (HPLC), solid S-(+)-PD 123177 is selective AT2 angiotensin receptor antagonist. The angiotensin AT2 receptor is an atypical seven transmembrane domain receptor that is coupled to activation of tyrosine phosphatase and inhibition of MAP kinase, and does not undergo agonist-induced internalization. An investigation of the occurrence and nature of AT2 receptor phosphorylation revealed that phorbol ester-induced activation of protein kinase C (PKC) in HA-AT2 receptor-expressing COS-7 cells caused rapid and specific phosphorylation of a single residue (Ser354) located in the cytoplasmic tail of the receptor. Agonist activation of AT2 receptors by angiotensin II (Ang II) also caused rapid PKC-dependent phosphorylation of Ser354 that was prevented by the AT2 antagonist, S-(+)-PD 123177, and by inhibitors of PKC. In cells coexpressing AT1 and AT2 receptors, Ang II-induced phosphorylation of the AT2 receptor was reduced by S-(+)-PD 123177 and abolished by treatment with both antagonists or with PKC inhibitors. These findings indicate that the AT2 receptor is rapidly phosphorylated via PKC during homologous activation by Ang II, and also undergoes heterologous PKC-dependent phosphorylation during activation of the AT1 receptor.
P186 PD 123,319 di(trifluoroacetate) salt hydrate powder, ≥98% (HPLC) PD123,319 di (trifluoroacetate) salt hydrate is a widely used angiotensin II subtype-2 receptor (AT2R) antagonist to study the role of AT2 receptor in vitro and in vivo. It increases the AngII-induced abdominal aortic aneurysms (AAAs) without interacting with AT2 receptor.