CRF

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A8727 Antalarmin hydrochloride ≥98% (HPLC), solid Antalarmin hydrochloride is a non-peptide CRF1 corticotropin-releasing factor receptor antagonist.
A4727 Antisauvagine-30 trifluoroacetate salt High-affinity antagonist for Corticotropin-releasing factor (CRF) receptor type 2 (CRF(2)).
A4933 Astressin ≥90% (HPLC) Highly potent CRF antagonist.
A5227 Astressin2B trifluoroacetate salt ≥98% (HPLC) Astressin2B is a CRH2 corticotropin-releasing hormone receptor antagonist.Corticotropin Releasing Factor (CRF), its family members, and competitive antagonists such as astressin assume an alpha-helical conformation when interacting with their receptors.
C2917 Corticotropin Releasing Factor Antagonist ≥97% (HPLC) The corticotropin releasing factor (CRF) antagonist α-helical CRF [9-41] exhibits 10-fold higher affinity for rat CRF receptors over human CRF receptors. It has been used to elucidate the role of CRF in various physiological systems. In colonic epithelium, it abolishes CRF-induced changes in ion secretion, and significantly inhibits CRF-stimulated conductance. It antagonizes the CRF-induced proinflammatory degranulation of perivascular mast cells that are activated in response to acute psychological stress and CRF secretion.
C2671 Corticotropin Releasing Factor bovine ≥90% (HPLC), Synthetic CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
C0961 Corticotropin Releasing Factor Fragment 6-33 human, rat ≥97% (HPLC) CRF fragment that binds with high affinity to the CRF binding protein (CRF-BP) but has low affinity for the CRF receptor. Displaces CRF from CRF-BP.
C3042 Corticotropin Releasing Factor human, rat ≥95% (HPLC) CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
C3167 Corticotropin Releasing Factor sheep ≥95% (HPLC) CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
PZ0100 CP-154526 hydrochloride ≥98% (HPLC) CP-154526 is a selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1).
L9167 LWH-63 hydrochloride ≥98% (HPLC), solid Non-peptide CRF1 corticotrophin-releasing factor antagonist. Ki = 0.68 nM; blocks ethanol-induced effects as well as CRF effects in mice, suggesting a possible therapeutic target for the treatment of stress-induced alcohol drinking.
N3911 NBI 27914 ≥98% (HPLC) NBI 27914 is a CRF1 corticotropin-releasing factor receptor antagonist.
S3941 Stresscopin trifluoroacetate salt human ≥90% (HPLC) Neuropeptide involved in the stress-coping responses. Specific ligand for the corticotropin-releasing hormone receptor type 2 (CRHR2).
S5441 Stresscopin-related peptide amide human trifluoroacetate salt A specific ligand for the corticotropin-releasing hormone receptor type 2 (CRHR2).
U4127 Urocortin human ≥85% (HPLC), powder Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.
Urocortin is a CRF-related neuropeptide having high affinity for CRF2 receptor possess appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.
U1008 Urocortin III human ≥97% (HPLC) Selective ligand with high affinity for CRF2 Receptors
Urocortin III belongs to corticotropin-releasing hormone family with high affinity for the type 2 corticotropin-releasing factor (CRFR2) receptor. It stimulates insulin and glucagon secretion.Urocortin III also possesses cardioprotective property and has minimal impact on the hypothalamic stress axis. It is, therefore, utilized for treating ischemic heart disease.
U9507 Urocortin II mouse Urocortin II is a CRF-related neuropeptide having high affinity for CRF2 receptor. It stimulates protein kinase A through CRF2 receptor and increases the contractility in rabbit ventricular myocytes. It also facilitates pro-inflammatory effects in human intestinal cells through corticotropin-releasing hormone receptor 2α.
corticotropin-releasing factor (CRF) peptide
U6631 Urocortin rat ≥97% (HPLC), powder Binds to CRF receptor types 1, 2α, and 2β; stimulates cAMP accumulation from cells transfected with these receptors. Acts in vitro to release ACTH from rat anterior pituitary cells.
Urocortin is a CRF-related neuropeptide that binds to CRF receptor types 1α, 2α and 2β. It possesses appetite-suppressing effect. Urocortin along with corticotropin-releasing factor (CRF) binding protein (CRF-BP) enhances the free CRF levels in human brain by displacing hCRF from the binding protein.