Antagonists

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D034 (−)-Butaclamol hydrochloride solid Dopamine receptor antagonist; less active enantiomer.
    • S8010 (±)-Sulpiride D2 dopamine receptor antagonist; antipsychotic.
    • D046 (+)-Bulbocapnine hydrochloride solid Dopamine receptor antagonist; Water-soluble form of (+)-Bulbocapnine
    • D033 (+)-Butaclamol hydrochloride solid (+)-Butaclamol is a dopamine receptor antagonist; active enantiomer.
    • S7771 (S)-(−)-Sulpiride ≥98% (titration) D2 dopamine receptor antagonist; antipsychotic.
    • D043 (S)-(+)-Apomorphine hydrochloride hydrate solid Dopamine receptor antagonist; inactive as an agonist.
    • A7111 Acepromazine maleate ≥98% (HPLC) Acepromazine is a phenothiazine antipsychotic comonly used as a veterinary drug (horses, dogs and cats). The compound is an analogue antipsychotic drug chlorpromazine (#C8138). The drug is thought to block receptors of dopamine in the brain. Recently it was discover that the compound inhibits ABCG2 transported protein, which overexpression in tumors is associated with drug resistance.
    • A2729 Amisulpride ≥98% (HPLC), solid Amisulpride is a highly selective D2/D3 dopamine receptor antagonist and atypical antipsychotic.
    • C1671 Chlorprothixene hydrochloride D2 dopamine receptor antagonist; blocks a subset of GABAA receptors in rat cortex that is also blocked by clozapine; thioxanthine antipsychotic.
    • C6305 Clozapine Atypical antipsychotic compound. Selective antagonist for D4-dopamine receptor. Antagonist at 5-HT2A, 5-HT2C, 5-HT3, 5-HT6, and 5-HT7 serotonin receptors.
    • D122 Domperidone powder, ≥98% (HPLC) Peripheral dopamine receptor antagonist that does not cross the blood-brain barrier; anti-emetic.
    • D1414 Droperidol D1, D2 dopamine receptor antagonist; butyrophenone antipsychotic and anti-emetic.
    • F4429 FAUC 213 ≥98% (HPLC), solid Highly selective D4 dopamine receptor full antagonist
    • F4765 Fluphenazine dihydrochloride D1/D2 dopamine receptor antagonist; phenothiazine antipsychotic; H1 histamine receptor antagonist.
    • F100 Fluspirilene Dopamine receptor antagonist; antipsychotic; calcium channel blocker.
    • G0544 GR 103691 >98% (HPLC), solid D3 dopamine receptor antagonist.
    • H3041 Halopemide ≥98% (HPLC) Halopemide is a dopamine receptor antagonist and a phospholipase D2 inhibitor. Halopemide may be used as a screen to identify inhibitors of human PLD2 using an in vitro biochemical assay. It is also inhibitory at benzodiazepine binding sites.1
    • H1512 Haloperidol powder Butyrophenone antipsychotic; D2, D3, and D4 dopamine receptor antagonist.
    • SML0033 Itopride hydrochloride ≥98% (HPLC) Itopride is an acetylcholinesterase (AChE) inhibitor and D2 dopamine receptor antagonist. Itopride is used as a gastroprokinetic agent.
    • L135 L-741,626 ≥98% (HPLC), solid Selective D2 dopamine receptor antagonist.
    • L131 L-745,870 hydrochloride Selective D4 dopamine receptor antagonist.
    • L133 L-750,667 trihydrochloride solid Selective D4 dopamine receptor antagonist.
    • L8401 LE 300 solid Potent, selective D1 dopamine receptor antagonist.
    • L106 Loxapine succinate salt solid D2/D4 dopamine receptor antagonist; 5-HT2A/2B, 5-H7 serotonin receptor antagonist; dibenzoxazepine antipsychotic agent.
    • M4068 Mesoridazine benzenesulfonate ≥98% (HPLC), powder Mesoridazine benzenesulfonate is a D2 dopamine receptor antagonist; antipsychotic.
    • M0763 Metoclopramide hydrochloride solid D2 antagonist; 5-HT3 antagonist; antipsychotic; anti-emetic.
    • M1818 Molindone hydrochloride ≥98% (HPLC), solid D2 dopamine receptor antagonist; MAO inhibitor.
    • N140 N-(p-Isothiocyanatophenethyl)spiperone hydrochloride Selective irreversible D2 dopamine receptor antagonist.
    • S128 N-Methylspiperone hydrochloride solid D2 dopamine receptor antagonist.
    • SML0066 NGB 2904 hydrochloride ≥98% (HPLC) NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for rat and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine.
    • O111 Octoclothepin maleate salt solid D2 dopamine receptor antagonist; 5-HT2 serotonin receptor antagonist.
    • SML0018 PG01037 dihydrochloride hydrate ≥98% (HPLC) PG01037 dihydrochloride is a selective dopamine D3 receptor antagonist. It is more selective for D3 receptors than other D3 antagonists that are currently available with a D2/D3 selectivity ratio of 867and a D4/D3 selectivity ratio of 13,000.
    Selective dopamine D3 receptor antagonist
    • P6402 Perphenazine D2 dopamine receptor antagonist; α-adrenergic receptor antagonist and σ-receptor agonist; phenothiazine antipsychotic. Inhibits glutamate dehydrogenase in vitro.
    • P1793   Pimozide D2 dopamine receptor antagonist; binds with high affinity to the cloned 5-HT7 receptor; Ca2+ channel antagonist; antipsychotic
    • P3246 Pipamperone dihydrochloride ~99% (HPLC), powder D2 dopamine receptor antagonist; 5-HT2 serotonin receptor antagonist; antipsychotic.
    • P9178 Prochlorperazine dimaleate salt Phenothiazine antipsychotic; D2 dopamine receptor antagonist; antispasmodic
    • P6656 Promazine hydrochloride D2 dopamine receptor antagonist; phenothiazine antipsychotic.
    • P7780 Propionylpromazine hydrochloride Phenothiazine antipsychotic; D2 dopamine receptor antagonist.
    • Q3638 Quetiapine hemifumarate salt ≥98% (HPLC) Quetiapine hemifumarate is an atypical antipsychotic, a combined serotonin (5HT2) and dopamine (D2) receptor antagonist.
    • S159 R(−)-SCH-12679 maleate salt solid D1 dopamine receptor antagonist
    • D054 R(+)-SCH-23390 hydrochloride ≥98% (HPLC), solid R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist.
    • D206 S(−)-DS 121 hydrochloride solid Dopamine autoreceptor antagonist with some selectivity for the D3 dopamine receptor.
    • R121 S(−)-Raclopride (+)-tartrate salt >97%, solid Selective D2 dopamine receptor antagonist.
    • D041 S(+)-Propylnorapomorphine hydrochloride solid Limbic-selective dopamine antagonist.
    • E101 S-(−)-Eticlopride hydrochloride ≥98% (HPLC), powder Potent and selective D2 dopamine receptor antagonist.
    • PZ0174 Sonepiprazole hydrate ≥98% (HPLC) Sonepiprazole (U-101387) is a selective D4 dopamine antagonist. Ki = 10 nM for the dopamine D4.2 receptor.
    • S7395 Spiperone solid Selective D2 dopamine receptor antagonist; α1B-adrenoceptor antagonist; mixed 5-HT2A/5-HT1 serotonin receptor antagonist; antipsychotic.
    • T9025 Thioridazine hydrochloride ≥99% D2 dopamine receptor antagonist; phenothazine antipsychotic with reduced extrapyramidal side effects; Ca2+ channel blocker.
    • T0410 Tiapride hydrochloride D2 and D3 dopamine receptor antagonist; antipsychotic.
    • T103 Trifluperidol hydrochloride Dopamine receptor antagonist; antipsychotic.
    • U115 U-101958 maleate salt solid Selective D4 dopamine receptor antagonist.
    • U116 U-99194 maleate salt ≥98% (HPLC), solid U-99194 is a putative D3 antagonist with a 30-fold preference for the dopamine D3 vs. D2 receptor.
    • F114 cis-(Z)-Flupenthixol dihydrochloride ≥98% (HPLC), solid Antipsychotic; neuroleptic agent; dopamine receptor antagonist.