Galanins

Galanin is co-localized with acetylcholine and inhibits its release; inhibits the release of glutamic acid, decreases excitability of spinal neurons; blocks voltage-activated Ca2+ channels; linked to behavioral and cognitive deficits in Alzheimer′s disease.

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G0278 Galanin human ≥97% (HPLC), powder Galanin (GAL) is involved in multiple physiological actions such as, nociception, cognition, memory, hunger, hormone and neurotransmitter release, and cell growth. It also controls the release of gastric acid, plays a role in the contraction of intestines, and suppresses the secretion of pancreatic peptides. This peptide is up-regulated in colorectal cancer (CRC), which relates to aggressive phenotype and poor prognosis of patients with stage II CRC. Studies in Chinese Han female population show that polymorphisms in this gene are linked to susceptibility to depression.
G8041 Galanin-Like Peptide Fragment 1-60 porcine trifluoroacetate salt ≥95% (HPLC), solid Endogenous ligand that preferentially binds to the GalR2 galanin receptor.
GALP-(1–60) peptide binds with high affinity to galanin receptor (GALR2). This peptide is thought to play a role in mediating the actions of leptin, a satiety hormone. It is a potent vasoactive peptide and is thought to be involved in inflammatory responses.
G5773 Galanin porcine ≥97% (HPLC), powder Studies show that galanin is capable of producing sustained but mild hyperglycemia in dogs. It also induces contraction in smooth muscle preparations obtained from fundus strip, ileum, colon and urinary bladder from rats. It shows structural similarities at the C-terminal to other neuropeptides, and thus, might also function as a neuropeptide. This peptide is a candidate hypothalamic-hypophysiotropic hormone, and is thought to affect the release of various pituitary hormones, such as growth hormone (GH), prolactin (PRL), and luteinizing hormone (LH).
Co-localized with acetylcholine and inhibits its release; inhibits the release of glutamic acid, decreases excitability of spinal neurons; blocks voltage-activated Ca2+ channels; linked to behavioral and cognitive deficits in Alzheimer′s disease.
G8293 Galanin (2-11) porcine, rat ≥97% (HPLC), lyophilized powder Studies in mice show that injection of galanin (2-11) has anticonvulsant activity in seizure affected animals with an intact DR (dorsal root)–hippocampal serotonergic profile, and has no effect in animals with absent 5-HT (hydroxytryptamine) profile.
G1278 Galantide ≥90% (HPLC) Galanin receptor antagonist
Galanin, a neuropeptide, mediates its physiological effects through three G protein-coupled receptor (GCPR) subtypes, GalR1, GalR2, and GalR3. Galantide, C7, M35, and M40 are Galanin receptor antagonists used to differentiate and characterize Galanin receptor signaling pathways that impact processes such as acute pancreatitis.
SML0643 M617 trifluoroacetate salt ≥95% (HPLC) M617, galanin(1–13)-Gln14-bradykinin(2–9)amide, is a chimeric peptide that acts as a selective agonist for the Galanin GalR1 receptor. M617 shows 25-fold specificity for GalR1with Ki values of 0.23 for GAL1 and 5.71 nM for GAL2.