Endorphins

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E6136 α-Endorphin human ≥97% (HPLC) α-Endorphin is a substrate for transglutaminase, and has stimulatory effects on immune system function. It influences the self-stimulating tendencies in rat, related to electrical stimulation of the ventral tegmentum area neurons. It counteracts the effect of γ-endorphin and promotes this behavior in rats. The functionality of α-endorphin is comparable to that of psychostimulant drugs, and as it acts in an opposing manner to γ-endorphin, these peptides might have a central role in the homeostasis of brain function.
E6261 β-Endorphin human ≥95% (HPLC) Potent endogenous opioid protein that is derived from propiomelanocortin, a protein found in the brain, anterior pituitary, skin, immune system, and other peripheral sites. It is released in response to painful stimuli and has potent antinociceptive activity that is mediated through its action on μ receptors in brain and by μ and κ receptors in the spinal cord.
β-Endorphin acts as a ligand for both μ and δ opioid receptors in different parts of the brain. It is released in response to painful stimuli and has potent antinociceptive activity. When given supraspinally, this activity is mediated through its action on ε-opioid receptors in brain that results in the release of Met-enkephalin. This activity is also mediated by its interaction with δ2-opioid receptors in the spinal cord. When introduced intrathecally, this function is an outcome of its interaction with μ and κ-opioid receptors in the rat. In autoimmune disorders, the elevated production of cytokines results in the production of β-endorphin, in pituitary and lymphocytes. This acts as a negative regulator of antibody production, and is thus, implicated in autoimmune diseases.
E1142 β-Endorphin rat ≥97% (HPLC) Potent endogenous opioid protein that is derived from propiomelanocortin, a protein found in the brain, anterior pituitary, skin, immune system, and other peripheral sites. It is released in response to painful stimuli and has potent antinociceptive activity that is mediated through its action on μ receptors in brain and by μ and κ receptors in the spinal cord.