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G Protein Function Enzymes

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A3352 Acyl-coenzyme A Synthetase from Pseudomonas sp. ≥2 units/mg protein Acyl coenzyme A synthetase proteins are involved in regulating and facilitating long-chain fatty acid transport in mammalian cells .
SRP4814 D4-GDI human recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)  
SRP3284 GASP-1 human recombinant, expressed in CHO cells, ≥95% (SDS-PAGE), ≥95% (HPLC) Growth and differentiation factor-associated serum protein-1 (GASP-1) is a secreted inhibitory TGF-β binding protein that contains multiple protease inhibitor structural domains. Recombinant human GASP-1 is a 542 amino acid protein that migrates at an apparent molecular weight of approximately 55-66 kDa by SDS-PAGE analysis under non-reducing conditions.
R2027 Ral B human recombinant, expressed in E. coli, buffered aqueous glycerol solution Ral B (21 kDa, native), a member of the Ras-like GTP binding protein family, is a crucial link in intracellular signaling cascades.
Ral B has been implicated in invasion and metastasis of human cancer cells. Reports have shown that depletion of Ral B by siRNA results in significantly reduced migration rates of tumor cells, while constitutively active Ral B promoted migration.
R2152 Rap1A human buffered aqueous glycerol solution, recombinant, expressed in E. coli, GST-tagged Rap1A, a small Ras-like GTP-binding protein (21 kDa, native), is a potential modulator of the Ras/Raf/MAP kinase intracellular signaling cascade.
R9894 Ras human Wild type, recombinant, expressed in E. coli, buffered aqueous glycerol solution  
W4392 W56 96% (HPLC), lyophilized powder W56 (concentrations >200 μM) selectively inhibits Rac1 interaction with Rac1-specific GEFs TrioN, GEF-H1, and Tiam1, which activate subsequent G proteins. The peptide comprises residues 45-60 of the β3 region of the guanine nucleotide exchange factor (GEF) recognition/activation site of Rac1. W56 targets the Trp56 site of Rac1. It has implications in research of actin cytoskeleton reorganization, transcriptional activation of genes, stimulation of DNA synthesis, endocytic and exocytic membrane trafficking, regulation of translation, and pathologies such as cancer.