Obesity Research

Hormones are chemical messengers that regulate physiological processes. Obesity, or excess body fat, is influenced by a variety of hormones. The hormones leptin, insulin, the sex hormones, and growth hormone influence appetite, metabolism, and body fat distribution.

Abnormal levels of these hormones disrupt metabolism and affect the accumulation of body fat. Obesity is associated with the increased risk of cardiovascular disease, stroke, and several types of cancer. It can decrease longevity and quality of life.

The body’s endocrine system is composed of numerous glands that secrete hormones into the bloodstream. Incorrect levels of hormones can lead to obesity and, in turn, obesity can lead to changes in hormone levels since fat cells themselves secrete hormones and affect hormone uptake. Sigma-Aldrich has a number of products to assist research on the hormonal components of obesity.

Adiponectin

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SML0998 AdipoRon ≥98% (HPLC)

CART

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C5977 CART Fragment 55-102 human ≥95% (HPLC)

Exendin

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E7019 Exendin-3 ≥97%
E7144 Exendin-4 ≥97%
E7269 Exendin Fragment 9-39 ≥95% (HPLC)

Genipin

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G4796 Genipin ≥98% (HPLC), powder Genipin stimulates insulin secretion in UCP2-dependent manner (Uncoupling protein 2). Genipin is a protein, collagen, gelatin, and chitosan cross-linker.

Ghrelin receptors

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PZ0317 Capromorelin tartrate ≥98% (HPLC)
SML1322 Ipamorelin acetate ≥98%
SML0993 MK-677 ≥98% (HPLC)
PZ0228 PF-04628935 ≥98% (HPLC)
PZ0270 PF-05190457 ≥95% (HPLC)
SML1148 YIL-781 hydrochloride ≥98% (HPLC)

Leptin (OB)

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L3772 Leptin from mouse >98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
L5037 Leptin from rat ≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
L4146 Leptin human >97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
L6788 Leptin Fragment 116-130 Amide mouse >95% (HPLC), white powder
SRP6018 Leptin Receptor human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
L4912 Leptin Receptor/Fc Chimera from mouse ≥97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested
L4787 Leptin Receptor/Fc Chimera human ≥97% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, cell culture tested

Melanocortin

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SML1197 ML 00253764 hydrochloride ≥98% (HPLC)
R3905 Ro 27-3225 trifluoroacetate salt ≥98% (reversed phase HPLC)

Neuropeptides

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B3559 Biotinyl-Melanin-Concentrating Hormone from salmon
SML1067 CYM50769 ≥98% (HPLC)
M4542 Melanin Concentrating Hormone rat ≥90% (HPLC)
M8441 Melanin Concentrating Hormone salmon ≥90%

Obestatin

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O0141 Obestatin human Obestatin, an obesity peptide, along with Ghrelin peptides are derived from the same prepropeptide, Ghrelin. In contrast to Ghrelin, Obestatin suppresses food intake, body weight gain, and gastrointestinal motility in rodents.
O0266 Obestatin mouse, rat synthetic Obestatin opposes the action of circulating appetite-inducing hormone-ghrelin and plays a vital role in weight regulation via hindering food intake, jejunal contraction and reducing the body weight. Obestatin mediates its activity by interacting with the G-protein coupled receptor 39 (GPR-39).
Obestatin, an obesity peptide, along with Ghrelin peptides are derived from the same prepropeptide, Ghrelin. In contrast to Ghrelin, Obestatin suppresses food intake, body weight gain, and gastrointestinal motility in rodents.

Omentin

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SRP8047 Omentin human recombinant, expressed in CHO cells, FLAG® tagged, >95% (SDS-PAGE)

Orexin

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SML1393 ACT-462206 ≥98% (HPLC)
A3355 ATC0175 ≥98% (HPLC), solid
SML0864 EMPA ≥98% (HPLC)
SML0230 GW-803430 ≥98% (HPLC)
O6012 Orexin A human, rat, mouse ≥97% (HPLC)
O6262 Orexin B rat, mouse ≥97% (HPLC)
SML1530 SB-334867 ≥98% (HPLC)
S2694 SB-408124 ≥98% (HPLC), solid
S0946 SB-668875 ≥95% (HPLC), solid
SML0912 SB 674042 ≥98% (HPLC)
SML0830 SNAP-94847 ≥98% (HPLC)

Other Obesity Products

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SML1160 CD40-TRAF6 signaling inhibitor ≥98% (HPLC)
SML1148 YIL-781 hydrochloride ≥98% (HPLC)

Uncoupling Proteins

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U6382 Anti-UCP-1 antibody produced in rabbit affinity isolated antibody, buffered aqueous solution
U7757 Anti-UCP-3 antibody produced in rabbit affinity isolated antibody, buffered aqueous solution