Sonic Hedgehog

Sonic Hedgehog (SHH) is a protein that plays a key role in the growth and development of many organisms. It is also important in the adult organism, where it controls cell division of adult stem cells. In addition, Sonic Hedgehog has also been implicated in the development of certain kinds of tumors.

A mutant version of the hedgehog gene causes Drosophila (fruit fly) embryos to be covered with small pointy projections, resembling a hedgehog. Sonic Hedgehog plays an important role in the growth of cutaneous appendages like hair, feathers, and scales, as well as limb and gut development.

Found in several different species including mouse, fruit fly, and human, SHH is an essential protein for vertebrate and invertebrate development. SHH acts as an axonal guidance cue, assuming various roles during the development of the central nervous system (CNS) in vertebrates.

In addition to the SHH ligand, Sigma-Aldrich offers several Hedgehog signaling pathway inhibitors for your research endeavors.

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SML0381 ALLO-1 ≥98% (HPLC)
SML0386 CUR61414 ≥98% (HPLC)
C4116 Cyclopamine hydrate ≥98% (HPLC)
SML0099 Fluocinonide ≥98% (HPLC)
G8923 GANT58 ≥98% (HPLC)
G9048 GANT61 ≥98% (HPLC)
H1542 HPI-1 hydrate
H4541 HPI-4 ≥98% (HPLC)
SML1363 IHR-1 ≥98% (HPLC)
J4145 Jervine ≥98% (HPLC), powder
J4205 JK184 ≥98% (HPLC), powder
SML0145 MRT-10 ≥98% (HPLC)
SML1155 22-NHC ≥98% (HPLC)
PZ0303 PF-04449913 maleate salt ≥98% (HPLC)
PZ0217 PF-5274857 hydrochloride ≥98% (HPLC)
SML0868 Purmorphamine ≥98% (HPLC)
SML1000 RU-SKI 43 maleate ≥98% (HPLC)
SML1314 SAG dihydrochloride ≥98% (HPLC)
S4572 SANT-1 ≥98% (HPLC), powder
SML0644 SANT-2 ≥95% (HPLC)
SRP3155 SLIT-2-N human recombinant, expressed in HEK 293 cells, ≥98% (SDS-PAGE), ≥98% (HPLC), cell culture tested
SML1211 SMANT hydrochloride ≥98% (HPLC)
SRP6004 Sonic Hedgehog from mouse recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC)
S0191 Sonic Hedgehog Peptide from mouse ≥97% (SDS-PAGE), recombinant, expressed in E. coli, Fused to a histidine tag at the C-terminus, lyophilized powder
T2909 Tomatidine hydrochloride ≥85%