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Neurotransmitter Receptors

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A2352 Acetylcholine Receptor α1, Fragment 129-145 Amino acids 129-145 of human, bovine, rat, and mouse sequence, ≥93% (HPLC)  
A6728 β1-Adrenergic Receptor preparation human Membranes suspended in 50 mM Tris-HCl containing 12 mM MgCl2 and 2 mM EDTA, pH 7.4. Actual concentration and specific binding capacity are provided with each lot.
A7231 AZ11645373 ≥98% (HPLC), solid AZ11645373 is a selective and potent human P2X7 purinoceptor antagonist. KB values range from 5-20 nM for human P2X7 receptor inhibition. It is 500-fold less effective ats an inhibitor of rat P2X7 receptor responses.
SML0852 CC4 ≥98% (HPLC) CC4 is a a partial agonist of α4β2 and α6β2 nicotinic acetylcholine receptors with low affinity for α3β4 and α7 containing receptors. CC4 reduces nicotine-induced self-administration and conditioned place preference without affecting motor functions.
C7743 CHPG ≥98% (HPLC), white solid CHPG is a selective, potent mGluR5 agonist. CHO cells expressing mGluR5 (but not those expressing mGluR1) are activated by CHPG. In vivo, CHPG stimulates thalamic neurons and is antagonized by MPEP (selective mGluR5 antagonist); CHPG potentiates NMDA and AMPA responses in spinal cord and produces oscillations in intracellular calcium in dorsal root ganglion cells.
D9071 Donitriptan monohydrochloride ≥98% (HPLC) Donitriptan is a potent, selective 5-HT1B/1D agonist.
D181 D3 Dopamine Receptor from rat recombinant, expressed in E. coli, membrane suspension  
E9658 Enalaprilat dihydrate ≥98% (HPLC) Enalaprilat is an inhibitor of angiotensin converting enzyme (ACE), antihypertensive, and a Bradykinin B1 receptor activator. Enalaprilat has nM potency versus ACE and also activates B1 receptors to release NO.
S177 5-HT7 Serotonin Receptor human recombinant, expressed in CHO cells, membrane suspension  
M2946 Mosapride citrate salt dihydrate 5-HT4 receptor agonist and 5-HT3 receptor antagonist
N4036 Neuropeptide Y Subtype 2 Receptor human membrane suspension Membranes suspended in 50 mM Tris-HCl containing 5 mM MgCl2, 0.1% BSA, and 10% glycerol, pH 7.7. Actual concentration and specific binding capacity are provided with each lot.
T180 NK2 Tachykinin Receptor human recombinant, expressed in CHO cells, membrane suspension  
P0043 PNU-120596 ≥98% (HPLC) An allosteric modulator of α7 nicotinic receptors, N-(5-chloro-2,4-dimethoxyphenyl)-N′-(5-methyl-3-isoxazolyl)-urea (PNU-120596), causes conformational changes in the extracellular ligand binding domain similar to those caused by acetylcholinePNU-120596 is a positive allosteric modulator selective for the α7 nicotinic acetylcholine receptor. PNU-120596 produces no detectable change in currents mediated by α4β2, α3β4, α9α10 nAChRs. It increases channel mean open time, but does not affect ion selectivity. It does not bind at the agonist binding site, but induces conformational changes similar to the natural effector.
R4282 RF9 trifluoroacetate salt ≥97% (HPLC) RF9 is a neuropeptide FF receptor antagonist. NPFF is a member of the FMRFamide (Phe-Met-Arg-PheNH2) family of neuropeptides, which are implicated in nociception and regulation of opioid analgesia. NPFF exhibits antiopioid activity (hyperalgesia). NPFF antagonists are expected to improve the therapeutic efficacy of opioids for treatment of chronic pain. The affinity of RF9 for NPFF1R and NPFF2R is 58 and 75 nM, respectively. RF9 acts as a potent competitive antagonist of NPFF at NPFF2R RF9 exhibits no agonist activity in GTPgS assays.
R3905 Ro 27-3225 trifluoroacetate salt ≥98% (reversed phase HPLC) Ro 27-3225 is a selective melanocortin MC4 receptor agonist. EC50 = 1 nM. Ro 27-3225 shows some activity at the MC1 receptor. Ro 27-3225 reverses hemorrhagic shock, reduces multiple organ damage, and improves survival. Ro 27-3225 may have a protective role against multiple organ failure following circulatory shock. Ro 27-3225 also reduces food intake in ob/ob mice.
S1943 Serotonin Transporter Receptor membrane suspension  
T2452 Talsaclidine ≥98% (HPLC), oil Talsaclidine is a M1 selective muscarinic receptor agonist. Concentration-dependently, talsaclidine increases the release of APPs and dose-dependently. Talsaclidine decreases Aβ formation and decreases cerebrospinal fluid Aβ in AD patients.
T8949 Telmisartan ≥98% (HPLC), solid Telmisartan is a non-peptide AT1 angiotensin receptor antagonist.
SMB00395 L-Theanine ≥98% (HPLC) L-Theanine modulates the activity of several antitumor drugs and has been reported to stimulate self-renewal of human embryonic stem cells. L-Theanine binds to AMPA, Kainate, NMDA, and group I mGlu receptors.
Theanine is able to bind to AMPA, kainite, and NMDA glycine receptors in rat cortical neurons but with less affinity than glutamic acid. It has been studied as a glutamate transport inhibitor, preventing glutamate uptake by M5076 ovarian sarcoma-bearing mouse cells and increasing the effect of doxorubicin on tumor growth in M5076 mice.
77965 Tris(2-ethylhexyl)phosphine oxide Selectophore, ≥95.0%