Sphingolipids

Sphingolipids are a class of lipids with a polar head group and two nonpolar tails. The core of a sphingolipid is an amino alcohol called sphingosine. Complex sphingolipids located in the plasma membrane of animal cells (especially nerve cells) have a structural function and are believed to protect the cell surface from harmful environmental factors. They also serve as adhesion sites for extracellular proteins and play important roles in signal transmission and cell recognition. Sphingolipids are involved in diseases including diabetes, cancer, microbial infections, neurological syndromes, and cardiovascular disease. Types of Sphingolipids include Ceramides, Phytoceramide, Sphingomyelins, Glycosphingolipids, Gangliosides, Cerebrosides, and Sulfatides (sulfated cerebrosides).

There is a great deal of knowledge about sphingolipids from biochemical studies of their signaling properties, the cloning of enzymes of sphingolipid metabolism, the development of genetic models of their physiological roles, and from methods for their detection and quantitation. Sigma-Aldrich has a variety of products to aid sphingolipid research.

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SML1744 A-971432 ≥95% (HPLC)
A7191 N-Acetyl-D-sphingosine ≥97% (TLC), powder
C8355 D-erythro-Ceramide C8 1-phosphate ≥93% (TLC), solid
SRP0339 Ceramide Kinase FLAG tag active human recombinant, expressed in baculovirus infected Sf9 cells, ≥40% (SDS-PAGE)
C4832 Ceramide 1-phosphate from bovine brain ~95%
C4987 Ceramide phosphorylethanolamine ≥98% (TLC)
C8480 D-erythro-Ceramine C8 98% (TLC), solid
SML0799 CYM 50179 ≥98% (HPLC)
SML1066 CYM50358 ≥98% (HPLC)
C1997 CYM-5442 ≥98% (HPLC)
SML1014 CYM-5520 ≥98% (HPLC)
SML0680 CYM-5541 ≥98% (HPLC)
C7980 Dihydroceramide C2 ≥98% (TLC), solid
C8230 Dihydroceramide C6 solid
C8605 Dihydroceramide C8 98%, waxy solid
D3314 D-erythro-Dihydrosphingosine ≥98%
D4681 L-threo-Dihydrosphingosine ≥95% (TLC)
D6783 DL-Dihydrosphingosine ≥98%, synthetic
D6908 DL-erythro-Dihydrosphingosine ≥99%, synthetic
D7033 DL-threo-Dihydrosphingosine ≥98%
D3439 D-erythro-Dihydrosphingosine 1-phosphate ≥98% (TLC), waxy solid
SML0311 N,N-Dimethylsphingosine ≥98% (HPLC)
SML0700 FTY720 ≥98% (HPLC)
SML0377 (S)-FTY720 phosphate ≥94% (HPLC)
C4905 Galactocerebrosides from bovine brain ≥97% (TLC)
H6524 N-Hexanoyl-D-sphingosine ≥98% (TLC), synthetic
J4080 JTE-013 ≥98% (HPLC)
N0912 NAEPA ≥98 (TLC), solid
N5908 N-(NBD-Aminocaproyl)sphinganine ≥98%
N6158 N-(NBD-Aminocaproyl)sphingosine β-D-galactosyl ≥98%
N6783 N-(NBD-Aminocaproyl)sphingosine β-D-glucosyl >98%
N8908 N-(NBD-Aminocaproyl)sphingosine β-D-lactosyl ≥98%
N9158 N-(NBD-Aminolauroyl)ceramide ≥98%
N3159 N-(NBD-Aminolauroyl)sphingomyelin >98%
N3409 N-(NBD-Aminolauroyl)sphingosine β-D-lactosyl >98%
C2137 Non-hydroxy fatty acid ceramide from bovine brain ≥99%
O1882 N-Octanoyl-D-sphingosine waxy solid
C8105 Phytoceramide C2 98% (TLC)
P9256 Psychosine from bovine brain lyophilized powder, ≥98% (TLC)
E9654 S1P4 C-Terminal Blocking Peptide ~1 mg/mL, buffered aqueous solution
E8278 S1P5 C-Terminal Blocking Peptide buffered aqueous solution
S3944 SEW2871 ≥98% (HPLC), solid
S2563 Sphingolipid Ceramide N-Deacylase from Pseudomonas sp.
S7049 D-Sphingosine synthetic
S9666 Sphingosine 1-phosphate ≥95%, powder
SRP0191 Sphingosine-1-phosphate lyase1 Active human recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE)
S4257 Sphingosylphosphorylcholine ≥98%, powder
T6330 THI
T1014 TNPAL-Sphingomyelin 1 mg/mL in chloroform/methanol (2:1)
U5760 (4R)-2-Undecyl-4-thiazolidinecarboxylic acid ≥98% (HPLC)
W1020 W146 hydrate ≥98% (HPLC)