Calcium-associated Proteins

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C1907 Calcineurin from bovine brain lyophilized powder, ≥2,500 units/mg protein Calcineurin is a cyclosporin-sensitive, calcium-regulated, serine-threonine protein phosphatase with broad substrate specificity. It is the major calmodulin-binding protein found in the brain. First identified as an inhibitor of the calmodulin activation of phosphodiesterase 3′:5′ cyclic nucleotide (PDE), calcineurin has similar effects on adenylate cyclase. Serves as a key enzyme involved in T-cell activation. Also involved in the hyperphosphorylation of tau protein in Alzheimer′s disease and has been shown to prevent calpain-mediated proteolysis of tau in differentiated PC12 cells.
P1431 Calmodulin from bovine testes BioUltra, ≥98% (SDS-PAGE), lyophilized powder Ca2+ binding protein that is required for activation of cyclic nucleotide-dependent phosphodiesterase. It is also a cofactor/activator of nitric oxide synthase, calcineurin, and many kinases including ATPase, myosin light chain kinase, and CAM kinase I, II, and III. It mediates ryanodine receptor activation by cyclic ADP ribose and is involved in intracellular Ca2+ homeostasis.
SRP5169 Calmodulin1, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution  
A6112 Calmodulin-Agarose saline suspension  
C4714 Calreticulin from bovine liver ≥90% (SDS-PAGE), lyophilized powder A high-affinity calcium binding protein which plays a dynamic role in calcium homeostasis. In addition, calreticulin binds directly to the DNA domain of hormone receptors as well as to the regulatory cytoplasmic domain of proteins of the integrin family. Calreticulin has also been shown to possess a chaperone function.
SRP8001 Calreticulin human recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)  
SRP4809 Calretinin from mouse recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC) Calretinin is widely distributed in the brain and might be responsible for neural protection. It regulates calcium signaling in neurons. Absence of calretinin in mice negatively affects long-term potentiation, motor coordination and Purkinje cell activity.
SRP5170 CaMKPase, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution  
SRP5203 LC20, GST tagged from mouse recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution  
SRP4913 Nesfatin-1 recombinant, expressed in E. coli, ≥95% (SDS-PAGE)  
SRP4914 Nesfatin-1 from rat recombinant, expressed in E. coli, ≥95% (SDS-PAGE)  
SRP3291 NESFATIN-1 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC) Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2). Recombinant human Nesfatin-1 is a 9.7 kDa protein containing 82 amino acid residues.
O5761 Osteocalcin fragment 1-49 Human ≥94% (HPLC), solid  
SRP5223 PAD1, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution  
SRP5224 PAD2, GST tagged from mouse recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution  
SRP5225 PAD3, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution  
SRP5226 PAD4, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution  
SRP5227 PAD6, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution  
SRP5147 Troponin1, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution  
T9924 Troponin I from human heart lyophilized powder The inhibiting subunit of troponin, responsible for preventing actin-myosin binding and ATPase activity.
Troponin I interacts with tropomyosin for regulating the contraction of striated muscle in a calcium-dependent manner. Additionally, Troponin I can also inhibits actomyosin ATPase and serves as a selective and potent inhibitor of angiogenesis in vivo and in vitro and of tumor metastasis in vivo.
T0175 Troponin T from human heart ≥60% (SDS-PAGE), lyophilized powder The tropomyosin-binding subunit of troponin