DNA Intercalators and Crosslinkers

Mutagenesis is the process of changing genetic information. This may occur spontaneously or from exposure to mutagens. The mutations that arise may be beneficial or harmful to the organism; a new trait may appear, but the mutation may also result in impaired gene function or death. In the laboratory, mutagenesis can help to determine gene function. Researchers can introduce specific mutations by using DNA intercalators and crosslinkers. DNA intercalators are molecules capable of fitting between nucleic acid base pairs. This reversible action leads researchers to new drugs and treatments since it can, for example, inhibit DNA replication in rapidly growing cancer cells. Crosslinking is when some agent connects two different positions either on the same strand or opposite strands of DNA. This cross-linking prevents DNA replication, leading to possible cell death and anticancer action. Several DNA intercalators and crosslinkers are available at Sigma-Aldrich for nucleic acid research.

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SML0983 5F-203 ≥98% (HPLC)
A8723 Altretamine solid
A4330 4′-Aminomethyltrioxsalen hydrochloride
SML1723 2-Amino-9H-pyrido[2-3-b]indole ≥98% (HPLC) New
A0956 Angelicin
ALD00034 (S)-tert-Butyl 1-(chloromethyl)-5-hydroxy-1H-benzo[e]indole-3(2H)-carboxylate 95% (HPLC)
C2538 Carboplatin
C0400 Carmustine ≥98%
C2235 CB 1954 solid
C0253 Chlorambucil
C7124 Cryptolepine hydrate ≥98% (HPLC)
C0768 Cyclophosphamide monohydrate bulk package
F7307 Fotemustine ≥98% (HPLC)
M2011 Melphalan powder
M6545 Mitoxantrone dihydrochloride ≥97% (HPLC)
N8659 Nimustine hydrochloride solid
O9512 Oxaliplatin solid
SML0036 Procarbazine hydrochloride ≥98% (HPLC)
P8399 Psoralen ≥99% (HPLC)
R4900 Rebeccamycin solid, ≥98% (HPLC), from Saccharothrix aerocolonigenes
SML0552 Tirapazamine ≥98% (HPLC)
SML1252 Treosulfan ≥98% (HPLC)
T6137 Trioxsalen ≥98% (HPLC), powder