Cell Cycle Regulators

The cell cycle controls replication and apoptosis, prevents uncontrolled cell division (tumor formation), and may involve detection and repair of damage to DNA. A conserved set of cyclin-dependent protein kinases (Cdks) initiate or regulate events through phosphorylation of intracellular proteins, thus controlling cell cycle progression, terminal differentiation, and apoptosis. Cdks bind to cyclins and form the maturation-promoting factor which phosphorylates multiple proteins at different stages of the cell cycle. Sigma offers a host of cell cycle regulators such as antimitotics, mitotic inhibitors, and cytokinesis inhibitors. Other small molecules available include DNA polymeraseinhibitors, apotosis inducers, antineoplastic agents, and antimetabolites. These compounds are valuable for better understandingcell cycle regulation, and carcinogenesis (oncogenesis, tumorigenesis).

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A3105 2-Amino-N-quinolin-8-yl-benzenesulfonamide ≥98% (HPLC), solid
    • A0781 Aphidicolin from Nigrospora sphaerica ≥98% (HPLC), powder
    • A3145 Apigenin ≥97% (TLC), from parsley, powder
    • SRP5167 BCR (1-695), GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • B1186 Binucleine 2 ≥97% (HPLC)
    • B0560 (−)-Blebbistatin solid, synthetic
    • B6688 BMS 493 ≥98% (HPLC)
    • SML0560 BRACO19 trihydrochloride ≥98% (HPLC) New
    • SRP5005 CDC25A, active, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5006 CDC25B, active, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5007 CDC25C, active, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5174 CDC42, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5342 CDK2, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution New
    • C3242 CDKi hydrochloride ≥98% (HPLC), solid
    • SRP5175 CDKN3, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • D7802 Daidzein ≥98%, synthetic
    • D4921 Destruxin A from Metarrhizium anisopliae ≥90% (HPLC)
    • SML0483 DpC ≥98% (HPLC)
    • E3656 (−)-Epothilone A from Sorangium cellulosum, >95% (HPLC), solid
    • E2656 (−)-Epothilone B from Sorangium cellulosum, ≥98% (HPLC), film
    • F3680 10058-F4 ≥98% (HPLC), solid
    • F4646 p-Fluoro-L-phenylalanine
    • F6627 5-Fluorouracil ≥99% (HPLC), powder
    • SRP5182 FRS3, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • G3798 10074-G5 ≥98% (HPLC)
    • G0548 14-3-3 Gamma, histidine-tagged human recombinant, expressed in E. coli, buffered aqueous glycerol solution, ≥90% (SDS-PAGE)
    • G6423 Gemcitabine hydrochloride ≥98% (HPLC)
    • SRP5155 14-3-3 ζ, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5157 14-3-3 θ, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5159 14-3-3 σ , GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • G7791 GW8510 solid
    • H4914 Honokiol ≥98% (HPLC), powder
    • B6312 14-3-3 Beta histidine-tagged human recombinant, expressed in E. coli, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
    • SML0341 Importazole ≥98% (HPLC)
    • I0404 Indirubin-3′-oxime ≥98% (HPLC), solid
    • I1159 trans-4-Iodo-4′-boranyl-chalcone ≥97% (HPLC), solid
    • I0763 N9-Isopropylolomoucine ≥98% (HPLC)
    • K3888 Kenpaullone ≥99%
    • SML0559 LDN193189 dihydrochloride ≥98% (HPLC) New
    • M0253 L-Mimosine from Koa hoale seeds ≥98%
    • M3047 Mizoribine ≥98% (TLC)
    • SML0407 ML 141 ≥98% (HPLC)
    • M8515 Monastrol ≥98% (HPLC), solid
    • SRP5102 Mortalin (47-end), GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SML0047 MoTP ≥98% (HPLC)
    • M3949 MST-312 ≥98% (HPLC)
    • M9823 Myra A hydrochloride ≥98% (HPLC), powder
    • SRP5103 NCK, His tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • N0164 Necrostatin-5 ≥98% (HPLC), solid
    • N3040 Necrostatin-7 ≥98% (HPLC), powder
    • N9653 Netropsin dihydrochloride from Streptomyces netropsis, ≥98% (HPLC and TLC), powder
    • SRP5105 NFKB2 (1-454), GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • N8914 NSC308848 ≥98% (HPLC), powder
    • N3414 NSC348884 hydrate
    • N8287 NSC 625987 ≥97% (HPLC)
    • N4286 NU2058 >98% (HPLC)
    • N4411 NU6027 ≥98% (HPLC)
    • O0886 Olomoucine ≥98% (HPLC)
    • SRP3134 p16-INK-4a human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), cell culture tested
    • SRP3135 p16-INK-4a TAT human recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC), cell culture tested
    • SRP5106 p18INK4C, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5107 p19INK4D, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5108 p21CIP1, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5109 p27KIP1, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5111 p33ING1, His tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5112 p63, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP4835 PCNA human recombinant, expressed in baculovirus infected Sf9 cells, ≥90% (SDS-PAGE), ≥90% (HPLC)
    • P7967 [Ala92]-Peptide 6
    • B7688 PiB ≥98% (HPLC)
    • SRP5119 PRKAR1A, His tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5120 PRKAR1B, His tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • P4484 Purvalanol A ≥98% (HPLC), powder
    • SML0481 Qc1 ≥98% (HPLC)
    • SRP5121 RAC1, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5122 RAC2, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5123 RAC3, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5124 Rb (48-378), GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP0256 RB Active human recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
    • R0382 Retrorsine ≥90% (HPLC)
    • SRP5126 RGS1, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5127 RhoA, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5128 RhoC, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5129 RhoD, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • R7772 Roscovitine ≥98% (TLC)
    • R7532 RRD-251 hydrochloride ≥98% (HPLC)
    • M6680 Se-(Methyl)selenocysteine hydrochloride ≥95% (TLC)
    • SRP5130 SMAD1, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5131 SMAD2, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • S4692 Sobuzoxane ≥99% (HPLC), solid
    • SML0440 Spautin-1 ≥98% (HPLC)
    • SRP5144 Stathmin, His tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • T1443 TCPOBOP ≥98% (HPLC), solid
    • 76899 Temozolomide VETRANAL™, analytical standard
    • SRP5145 TGFβR1 (80-end), GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5146 TRAF2, His tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • U3385 UA62784 ≥98% (HPLC)
    • SRP5152 14-3-3 α/β, untagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5156 14-3-3 ζ, untagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • W3763 WP631 methanesulfonate ≥97% (HPLC), solid
    • SRP5151 XIAP, GST tagged human recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • X3628 XK469 ≥98% (HPLC), solid
    • SML0176 Z36 ≥98% (HPLC)
    • Z4652 Zapotin from Casimiroa edulis (white sapote tree), ≥98% (HPLC)
    • T0953 14-3-3 Tau/Theta histidine-tagged human recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
    • Z3402 14-3-3 Zeta, histidine-tagged human recombinant, expressed in E. coli, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5158 14-3-3 θ, untagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • S7323 14-3-3 Sigma histidine-tagged human recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5160 14-3-3 σ, untagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • E2033 14-3-3 Epsilon histidine-tagged human recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous solution
    • E1408 14-3-3 Eta histidine-tagged human recombinant, expressed in E. coli, C-terminal, ≥90% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5153 14-3-3 ε, GST tagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
    • SRP5154 14-3-3 ε, untagged human recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution