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Enzyme inhibitors are compounds that interfere with or slow down proteolytic catalysis, often by competing with the natural substrate for access to the enzymatic active site. They can be used to investigate the mechanism of action and the details of biological processes, and are often sought as new therapeutic agents. Inhibitors of many enzymes, including hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, epoxide hydrolase, 15-hydroxyprostaglandin dehydrogenase (15-hydroxy-PGDH), , 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), LTA4 hydrolase, and more are subjects of active investigation for cardiovascular disease, allergy, malaria, and inflammation. Sigma’s collection of small molecules offers many of these enzyme inhibitors for your research.

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PZ0001 Atorvastatin calcium salt trihydrate ≥98% (HPLC)
SML1041 Atreleuton ≥98% (HPLC)
SML0177 AUDA ≥98% (HPLC)
SML0411 BAY-X-1005 ≥98% (HPLC)
C6734 CAY10397 >98%, solid
D0400 9,11-Dideoxy-9α,11α-epoxymethanoprostaglandin F
SML1815 Fasnall benzenesulfonate salt ≥98% (HPLC)
SML0038 Fluvastatin sodium hydrate ≥98% (HPLC)
F8682 Fosmidomycin sodium salt hydrate ≥95% (NMR)
SML1259 GSK2194069 ≥97% (HPLC)
SML0434 Gue1654 ≥98% (HPLC)
SML0254 4-MDM ≥98% (HPLC)
SML1353 ML351 ≥98% (HPLC)
O1385 Ozagrel hydrochloride hydrate ≥98% (HPLC), solid
PZ0326 PF-03549184 ≥98% (HPLC)
SML1777 Propacetamol hydrochloride ≥98% (HPLC)
R0531 Ramatroban ≥98% (HPLC), solid
SML1264 Rosuvastatin calcium ≥98% (HPLC)
P7495 SC 22716 ≥98% (HPLC)
PZ0176 SC-26196 ≥98% (HPLC)
PZ0110 SC-57461A ≥98% (HPLC)
SML1379 Seratrodast ≥98% (HPLC)
S9314 Sesamin ≥95%, crystalline
S6196 Simvastatin ≥97% (HPLC), solid
SML0750 TPPU ≥98% (HPLC)
T0318 Tranilast ≥98% (HPLC), powder
SML1694 TVB-3166 ≥98% (HPLC)