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Enzyme inhibitors are compounds that interfere with or slow down proteolytic catalysis, often by competing with the natural substrate for access to the enzymatic active site. They can be used to investigate the mechanism of action and the details of biological processes, and are often sought as new therapeutic agents. Inhibitors of many enzymes, including hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, epoxide hydrolase, 15-hydroxyprostaglandin dehydrogenase (15-hydroxy-PGDH), , 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR), LTA4 hydrolase, and more are subjects of active investigation for cardiovascular disease, allergy, malaria, and inflammation. Sigma’s collection of small molecules offers many of these enzyme inhibitors for your research.
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