Cathepsins and Granzymes Enzymes

Granzyme B
Granzyme B (OMIM #123910) and perforin (OMIM #170280), proteins released by an effector cell (cytotoxic T cell), can induce apoptosis in target cells by forming transmembrane pores and through cleavage of effector caspases such as caspase-3. In addition, caspase-independent mechanisms of granzyme B-mediated apoptosis have been suggested. Caspase-activated DNAse (CAD) is activated through the cleavage of its associated inhibitor ICAD by caspase-3. CAD is then able to interact with components such as topoisomerase II (Topo II) to condense chromatin, leading to DNA fragmentation and ultimately apoptosis.
Granzyme B and Perforin Induce Apoptosis in Target Cells

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SRP0289 Cathepsin B Active human recombinant, expressed in FreeStyle 293-F cells, ≥90% (SDS-PAGE)
SRP0290 Cathepsin F Active human recombinant, expressed in FreeStyle 293-F cells, ≥90% (SDS-PAGE)
SRP0291 Cathepsin L Active human recombinant, expressed in FreeStyle 293-F cells, ≥90% (SDS-PAGE)
SRP0292 Cathepsin S Active human recombinant, expressed in FreeStyle 293-F cells, ≥90% (SDS-PAGE)
SRP0293 Cathepsin V Active human recombinant, expressed in FreeStyle 293-F cells, ≥90% (SDS-PAGE)
CS0800 Cathepsin D Assay Kit sufficient for 120 assays (100 μL)
C6286 Cathepsin B from bovine spleen lyophilized powder, ≥10 units/mg protein
C8571 Cathepsin B from human liver buffered aqueous solution, ≥1,500 units/mg protein (E1%/280)
C3138 Cathepsin D from bovine spleen lyophilized powder, ≥2.0 units/mg protein
C8696 Cathepsin D from human liver lyophilized powder, ≥250 units/mg protein (E1%/280)
C4428 Cathepsin G from human leukocytes lyophilized powder, ≥60 units/mg protein (Bradford)
C5108 Cathepsin G from human sputum ≥0.2 units/mg protein, salt-free, lyophilized powder
C6854 Cathepsin L from human liver ≥0.5 units/mg protein, solution
G9278 Granzyme B from mouse ≥90% (SDS-PAGE), recombinant, expressed in Pichia pastoris, buffered aqueous solution, ≥10,000 units/mg protein
SRP3202 Granzyme B from mouse recombinant, expressed in Hi-5 Insect cells, ≥97% (SDS-PAGE), ≥97% (HPLC), cell culture tested
SRP6001 Procathepsin K human recombinant, expressed in E. coli, ≥95% (SDS-PAGE)